Investigation of antimalarial principles from seeds of Amomum krervanh (Zingiberaceae)
3
Issued Date
2024
Copyright Date
1993
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
iii, 195 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Organic Chemistry))--Mahidol University, 1993
Suggested Citation
Chongdee Nilanonta Investigation of antimalarial principles from seeds of Amomum krervanh (Zingiberaceae). Thesis (M.Sc. (Organic Chemistry))--Mahidol University, 1993. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99946
Title
Investigation of antimalarial principles from seeds of Amomum krervanh (Zingiberaceae)
Alternative Title(s)
การค้นคว้าสารต้านมาลาเรียจากเมล็ดกระวานขาวไทย
Author(s)
Advisor(s)
Abstract
The investigation of antimalarial principles from the seeds of Amomum krervanh ( ZINGIBERACEAE ) has led to the separation of seven pure compounds comprising four monoterpenes, one flavonoid and possibly two diterpenes. Three of the monoterpenes are known compounds, viz: myrtenal, myrtenol and trans -pinocarveol, while the fourth is a new compound whose structure has been elucidated as trans -3-hydroxymyrtenal. The flavonoid has been found to be 3,7,4-trimethoxy-5-hydroxyflavone. Only partial st ave been proposed for the remaining two compounds which are thought to be diterpenes. The above compounds ( with exception of the flavonoid ) give EC50 values in the range 10-5-10-8 g/ml. Besides in vitro testing, in vivo tests were also carried out on myrtenol and one of the diterpenes which exhibited an in vitro EC50 value of 6.15 x 10-8 g/ml. However, in vivo test results are not yet conclusive due to problems concerning solubility of the compounds.
Description
Organic Chemistry (Mahidol University 1993)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Organic Chemistry
Degree Grantor(s)
Mahidol University