Superficial Intradermal Injections of Cohesive Polydensified Matrix Hyaluronic Acid Fillers for the Improvement of Facial Pores and Skin Quality: A Split-Face Randomized Study
Issued Date
2025-05-01
Resource Type
ISSN
14732130
eISSN
14732165
Scopus ID
2-s2.0-105004210801
Journal Title
Journal of Cosmetic Dermatology
Volume
24
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Cosmetic Dermatology Vol.24 No.5 (2025)
Suggested Citation
Rutnumnoi T., Palakornkitti P., Anuntrangsee T., Yongpisarn T., Sakpuwadol N., Vachiramon V. Superficial Intradermal Injections of Cohesive Polydensified Matrix Hyaluronic Acid Fillers for the Improvement of Facial Pores and Skin Quality: A Split-Face Randomized Study. Journal of Cosmetic Dermatology Vol.24 No.5 (2025). doi:10.1111/jocd.70209 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/110046
Title
Superficial Intradermal Injections of Cohesive Polydensified Matrix Hyaluronic Acid Fillers for the Improvement of Facial Pores and Skin Quality: A Split-Face Randomized Study
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Corresponding Author(s)
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Abstract
Background: Various therapeutic options have been introduced for enlarged facial pores including low cross-linked hyaluronic acid (HA) fillers. Newer formulations of HA-based dermal fillers are continuously introduced into the market, but their effectiveness in reducing enlarged facial pores has not yet been determined. Objectives: To compare the efficacy of HA-based dermal fillers (Cohesive Polydensified Matrix HA filler; CPM-HA20) versus CPM-HA20 with glycerol (CPM-HA20G) in terms of minimizing enlarged facial pores and skin quality improvement. Methods: Thirty subjects with enlarged facial pores were enrolled in this randomized, double-blinded, split-face study. Participants were randomly assigned to be injected with 1 mL of CPM-HA20 filler on one side of their medial cheek and 1 mL of CPM-HA20G on the contralateral side for 3 sessions spaced 4 weeks apart. Pore volume was objectively measured by an Antera 3D. Skin biophysical properties were evaluated. Participant satisfaction and adverse events were recorded. Results: Twenty-nine participants completed the study. Both treatment groups showed a reduction in the mean pore volume from the baseline through Week 32. The CPM-HA20G treated side showed a 24.2% higher reduction in mean pore volume from baseline compared to the CPM-HA20 treated side (p = 0.038). Both treatment groups showed improvement in skin hydration from baseline to Week 32. There was no significant difference in patient satisfaction between the CPM-HA20G and CPM-HA20 treated sides. Only mild adverse events such as pain, edema, and bruising were reported. Conclusion: Three-monthly injections of CPM-HA20G and CPM-HA20 were effective in minimizing enlarged face pores and improving skin hydration. CPM-HA20G demonstrated superior efficacy in terms of pore size reduction. Adverse events were generally mild and tolerable.