The effects of antimalarial drugs on cholinesterase activity in malarial infected rodents
2
Issued Date
1991
Copyright Date
1991
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
vii, 62 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Pharmacology))--Mahidol University, 1991
Suggested Citation
Atchara Chaiyawat The effects of antimalarial drugs on cholinesterase activity in malarial infected rodents. Thesis (M.Sc. (Pharmacology))--Mahidol University, 1991. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103201
Title
The effects of antimalarial drugs on cholinesterase activity in malarial infected rodents
Alternative Title(s)
ฤทธิ์ของยาต้านมาเลเรียต่อเอ็นไซม์โคลีนเอสเตอเรสในหนูที่เป็นมาเลเรีย
Author(s)
Abstract
The alteration in serum and whole blood choolinesterase in Plasmodium berghei infected,chloroquine-treated or untreated mice were followed for 6 days. Choroquine, the 4-aminoquinoline, had been known for its effective with rapid onset and inexpensive antimalarial drug. The in vitro anticholinesterase activity of chloroquine was reported by many investigators. In this study, attempts have been made to study the time course of alteration in serum cholinesterase during P. berghei infection, and observe the effect of minimum effective dose of chloroquine on serum cholinesterase activityy. Serum cholinesterase activity of malarial infected mich was markedly increased whereas chloroquine did not have any effect on this enzyme. The same result was obtained in the whole blood cholinesterase measurement. Low dose of methyl parathion that enough to produce detectable lowering of cholinesterase activity but did not exhibit cholinergic overactivity such as salivation or lacrimation, did not have any effect on the progression of malarial infection. The median lethal dose (LD(,50) of methyl parathion in malarial-infected group was higher than the control, non-infected group. However, paraoxon, the active metabolite of parathion had the lower LD(,50) value in P. berghei infected group than the uninfected group. The results from this study suggested that the increased serum cholinesterase during P. berghei infection may alter the toxic effects of the anticholinesterase agents.
Description
Pharmacology (Mahidol University 1991)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Pharmacology
Degree Grantor(s)
Mahidol University