La-Ongthong K., Chantarojsiri T., Soorukram D., Leowanawat P., Reutrakul V., Kuhakarn C. Electrochemical trifluoromethylation of 2-isocyanobiaryls using CF<inf>3</inf>SO<inf>2</inf>Na: synthesis of 6-(trifluoromethyl)phenanthridines. Organic and Biomolecular Chemistry (2023). doi:10.1039/d3ob00239j Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82325
Title
Electrochemical trifluoromethylation of 2-isocyanobiaryls using CF<inf>3</inf>SO<inf>2</inf>Na: synthesis of 6-(trifluoromethyl)phenanthridines
An efficient trifluoromethylation of 2-isocyanobiaryls was developed through the constant current electrolysis, employing sodium trifluoromethanesulfinate (CF3SO2Na) as the trifluoromethyl source. The method enabled the syntheses of a series of 6-(trifluoromethyl)phenanthridine derivatives in moderate to high yields under metal- and oxidant-free conditions. A gram-scale synthesis highlights the synthetic versatility of the reported protocol.
