Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients — insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysis
Issued Date
2022-12-01
Resource Type
ISSN
13648535
eISSN
1466609X
Scopus ID
2-s2.0-85131270278
Pubmed ID
35650616
Journal Title
Critical Care
Volume
26
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Critical Care Vol.26 No.1 (2022)
Suggested Citation
Ahuja S., de Grooth H.J., Paulus F., van der Ven F.L., Serpa Neto A., Schultz M.J., Tuinman P.R., Ahuja S., van Akkeren J.P., Algera A.G., Algoe C.K., van Amstel R.B., Artigas A., Baur O.L., van de Berg P., van den Berg A.E., Bergmans D.C.J.J., van den Bersselaar D.I., Bertens F.A., Bindels A.J.G.H., de Boer M.M., den Boer S., Boers L.S., Bogerd M., Bos L.D.J., Botta M., Breel J.S., de Bruin H., de Bruin S., Bruna C.L., Buiteman-Kruizinga L.A., Cremer O.L., Determann R.M., Dieperink W., Dongelmans D.A., Franke H.S., Galek-Aldridge M.S., de Graaff M.J., Hagens L.A., Haringman J.J., van der Heide S.T., van der Heiden P.L.J., Heijnen N.F.L., Hiel S.J.P., Hoeijmakers L.L., Hol L., Hollmann M.W., Hoogendoorn M.E., Horn J., van der Horst R., Ie E.L.K., Ivanov D., Juffermans N.P., Kho E., de Klerk E.S., Koopman-van Gemert A.W.M.M., Koopmans M., Kucukcelebi S., Kuiper M.A., de Lange D.W., van Mourik N., Nijbroek S.G., Onrust M., Oostdijk E.A.N., Paulus F., Pennartz C.J., Pillay J., Pisani L., Purmer I.M., Rettig T.C.D., Roozeman J.P., Schuijt M.T.U., Schultz M.J., Sleeswijk M.E., Smit M.R., Spronk P.E., Stilma W., Strang A.C., Tsonas A.M., Tuinman P.R., Valk C.M.A., Veen-Schra F.L., Veldhuis L.I., van Velzen P., van der Ven W.H., Vlaar A.P.J., van Vliet P., van der Voort P.H.J., van Welie L., Wesselink H.J.F.T., van der Wier-Lubbers H.H., van Wijk B., Winters T., Wong W.Y., van Zanten A.R.H. Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients — insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysis. Critical Care Vol.26 No.1 (2022). doi:10.1186/s13054-022-04023-y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85303
Title
Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients — insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysis
Author(s)
Ahuja S.
de Grooth H.J.
Paulus F.
van der Ven F.L.
Serpa Neto A.
Schultz M.J.
Tuinman P.R.
Ahuja S.
van Akkeren J.P.
Algera A.G.
Algoe C.K.
van Amstel R.B.
Artigas A.
Baur O.L.
van de Berg P.
van den Berg A.E.
Bergmans D.C.J.J.
van den Bersselaar D.I.
Bertens F.A.
Bindels A.J.G.H.
de Boer M.M.
den Boer S.
Boers L.S.
Bogerd M.
Bos L.D.J.
Botta M.
Breel J.S.
de Bruin H.
de Bruin S.
Bruna C.L.
Buiteman-Kruizinga L.A.
Cremer O.L.
Determann R.M.
Dieperink W.
Dongelmans D.A.
Franke H.S.
Galek-Aldridge M.S.
de Graaff M.J.
Hagens L.A.
Haringman J.J.
van der Heide S.T.
van der Heiden P.L.J.
Heijnen N.F.L.
Hiel S.J.P.
Hoeijmakers L.L.
Hol L.
Hollmann M.W.
Hoogendoorn M.E.
Horn J.
van der Horst R.
Ie E.L.K.
Ivanov D.
Juffermans N.P.
Kho E.
de Klerk E.S.
Koopman-van Gemert A.W.M.M.
Koopmans M.
Kucukcelebi S.
Kuiper M.A.
de Lange D.W.
van Mourik N.
Nijbroek S.G.
Onrust M.
Oostdijk E.A.N.
Paulus F.
Pennartz C.J.
Pillay J.
Pisani L.
Purmer I.M.
Rettig T.C.D.
Roozeman J.P.
Schuijt M.T.U.
Schultz M.J.
Sleeswijk M.E.
Smit M.R.
Spronk P.E.
Stilma W.
Strang A.C.
Tsonas A.M.
Tuinman P.R.
Valk C.M.A.
Veen-Schra F.L.
Veldhuis L.I.
van Velzen P.
van der Ven W.H.
Vlaar A.P.J.
van Vliet P.
van der Voort P.H.J.
van Welie L.
Wesselink H.J.F.T.
van der Wier-Lubbers H.H.
van Wijk B.
Winters T.
Wong W.Y.
van Zanten A.R.H.
de Grooth H.J.
Paulus F.
van der Ven F.L.
Serpa Neto A.
Schultz M.J.
Tuinman P.R.
Ahuja S.
van Akkeren J.P.
Algera A.G.
Algoe C.K.
van Amstel R.B.
Artigas A.
Baur O.L.
van de Berg P.
van den Berg A.E.
Bergmans D.C.J.J.
van den Bersselaar D.I.
Bertens F.A.
Bindels A.J.G.H.
de Boer M.M.
den Boer S.
Boers L.S.
Bogerd M.
Bos L.D.J.
Botta M.
Breel J.S.
de Bruin H.
de Bruin S.
Bruna C.L.
Buiteman-Kruizinga L.A.
Cremer O.L.
Determann R.M.
Dieperink W.
Dongelmans D.A.
Franke H.S.
Galek-Aldridge M.S.
de Graaff M.J.
Hagens L.A.
Haringman J.J.
van der Heide S.T.
van der Heiden P.L.J.
Heijnen N.F.L.
Hiel S.J.P.
Hoeijmakers L.L.
Hol L.
Hollmann M.W.
Hoogendoorn M.E.
Horn J.
van der Horst R.
Ie E.L.K.
Ivanov D.
Juffermans N.P.
Kho E.
de Klerk E.S.
Koopman-van Gemert A.W.M.M.
Koopmans M.
Kucukcelebi S.
Kuiper M.A.
de Lange D.W.
van Mourik N.
Nijbroek S.G.
Onrust M.
Oostdijk E.A.N.
Paulus F.
Pennartz C.J.
Pillay J.
Pisani L.
Purmer I.M.
Rettig T.C.D.
Roozeman J.P.
Schuijt M.T.U.
Schultz M.J.
Sleeswijk M.E.
Smit M.R.
Spronk P.E.
Stilma W.
Strang A.C.
Tsonas A.M.
Tuinman P.R.
Valk C.M.A.
Veen-Schra F.L.
Veldhuis L.I.
van Velzen P.
van der Ven W.H.
Vlaar A.P.J.
van Vliet P.
van der Voort P.H.J.
van Welie L.
Wesselink H.J.F.T.
van der Wier-Lubbers H.H.
van Wijk B.
Winters T.
Wong W.Y.
van Zanten A.R.H.
Author's Affiliation
Mahidol Oxford Tropical Medicine Research Unit
Melbourne Medical School
Hogeschool van Amsterdam, University of Applied Sciences
Cleveland Clinic Foundation
Hospital Israelita Albert Einstein
Faculty of Medicine, Nursing and Health Sciences
Nuffield Department of Medicine
Henry Ford Hospital
Amsterdam UMC - University of Amsterdam
Location VU Medical Center
Melbourne Medical School
Hogeschool van Amsterdam, University of Applied Sciences
Cleveland Clinic Foundation
Hospital Israelita Albert Einstein
Faculty of Medicine, Nursing and Health Sciences
Nuffield Department of Medicine
Henry Ford Hospital
Amsterdam UMC - University of Amsterdam
Location VU Medical Center
Other Contributor(s)
Abstract
Background: Increasing evidence indicates the potential benefits of restricted fluid management in critically ill patients. Evidence lacks on the optimal fluid management strategy for invasively ventilated COVID-19 patients. We hypothesized that the cumulative fluid balance would affect the successful liberation of invasive ventilation in COVID-19 patients with acute respiratory distress syndrome (ARDS). Methods: We analyzed data from the multicenter observational ‘PRactice of VENTilation in COVID-19 patients’ study. Patients with confirmed COVID-19 and ARDS who required invasive ventilation during the first 3 months of the international outbreak (March 1, 2020, to June 2020) across 22 hospitals in the Netherlands were included. The primary outcome was successful liberation of invasive ventilation, modeled as a function of day 3 cumulative fluid balance using Cox proportional hazards models, using the crude and the adjusted association. Sensitivity analyses without missing data and modeling ARDS severity were performed. Results: Among 650 patients, three groups were identified. Patients in the higher, intermediate, and lower groups had a median cumulative fluid balance of 1.98 L (1.27–7.72 L), 0.78 L (0.26–1.27 L), and − 0.35 L (− 6.52–0.26 L), respectively. Higher day 3 cumulative fluid balance was significantly associated with a lower probability of successful ventilation liberation (adjusted hazard ratio 0.86, 95% CI 0.77–0.95, P = 0.0047). Sensitivity analyses showed similar results. Conclusions: In a cohort of invasively ventilated patients with COVID-19 and ARDS, a higher cumulative fluid balance was associated with a longer ventilation duration, indicating that restricted fluid management in these patients may be beneficial. Trial registration Clinicaltrials.gov (NCT04346342); Date of registration: April 15, 2020. Graphical abstract: [Figure not available: see fulltext.]