Effect of automated versus conventional ventilation on mechanical power of ventilation-A randomized crossover clinical trial
Issued Date
2024-07-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85199940935
Journal Title
PLoS ONE
Volume
19
Issue
7 July
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS ONE Vol.19 No.7 July (2024)
Suggested Citation
Buiteman-Kruizinga L.A., Neto A.S., Botta M., List S.S., de Boer B.H., van Velzen P., Bühler P.K., Wendel Garcia P.D., Schultz M.J., van der Heiden P.L.J., Paulus F., Appel R.J.A., van den Berg A., Bierlee M.C.W.M., Boezaart D., Boots J.A., Bosman B., Bühler P., Fehlbier K.J., Goossen R.L., Guseva A.A., Hoekstra-Kapitein C., Kleinert E.M., Last H., van Leijsen T.D., Luttmer-Laven M., Remmerswaal L., Schriel-Van den Berg Y., Sinnige J.S., Tsonas A.M., Vermeulen T. Effect of automated versus conventional ventilation on mechanical power of ventilation-A randomized crossover clinical trial. PLoS ONE Vol.19 No.7 July (2024). doi:10.1371/journal.pone.0307155 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100238
Title
Effect of automated versus conventional ventilation on mechanical power of ventilation-A randomized crossover clinical trial
Author(s)
Buiteman-Kruizinga L.A.
Neto A.S.
Botta M.
List S.S.
de Boer B.H.
van Velzen P.
Bühler P.K.
Wendel Garcia P.D.
Schultz M.J.
van der Heiden P.L.J.
Paulus F.
Appel R.J.A.
van den Berg A.
Bierlee M.C.W.M.
Boezaart D.
Boots J.A.
Bosman B.
Bühler P.
Fehlbier K.J.
Goossen R.L.
Guseva A.A.
Hoekstra-Kapitein C.
Kleinert E.M.
Last H.
van Leijsen T.D.
Luttmer-Laven M.
Remmerswaal L.
Schriel-Van den Berg Y.
Sinnige J.S.
Tsonas A.M.
Vermeulen T.
Neto A.S.
Botta M.
List S.S.
de Boer B.H.
van Velzen P.
Bühler P.K.
Wendel Garcia P.D.
Schultz M.J.
van der Heiden P.L.J.
Paulus F.
Appel R.J.A.
van den Berg A.
Bierlee M.C.W.M.
Boezaart D.
Boots J.A.
Bosman B.
Bühler P.
Fehlbier K.J.
Goossen R.L.
Guseva A.A.
Hoekstra-Kapitein C.
Kleinert E.M.
Last H.
van Leijsen T.D.
Luttmer-Laven M.
Remmerswaal L.
Schriel-Van den Berg Y.
Sinnige J.S.
Tsonas A.M.
Vermeulen T.
Author's Affiliation
Mahidol Oxford Tropical Medicine Research Unit
Hogeschool van Amsterdam, University of Applied Sciences
University of Melbourne
UniversitatsSpital Zurich
Monash University
Hospital Israelita Albert Einstein
Medizinische Universität Wien
Nuffield Department of Medicine
Austin Hospital
Amsterdam UMC - University of Amsterdam
Reinier de Graaf Hospital - SSDZ
Dijklander Hospital – Location Hoorn
Hogeschool van Amsterdam, University of Applied Sciences
University of Melbourne
UniversitatsSpital Zurich
Monash University
Hospital Israelita Albert Einstein
Medizinische Universität Wien
Nuffield Department of Medicine
Austin Hospital
Amsterdam UMC - University of Amsterdam
Reinier de Graaf Hospital - SSDZ
Dijklander Hospital – Location Hoorn
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction Mechanical power of ventilation, a summary parameter reflecting the energy transferred from the ventilator to the respiratory system, has associations with outcomes. INTELLiVENT-Adaptive Support Ventilation is an automated ventilation mode that changes ventilator settings according to algorithms that target a low work-and force of breathing. The study aims to compare mechanical power between automated ventilation by means of INTELLiVENT-Adaptive Support Ventilation and conventional ventilation in critically ill patients. Materials and methods International, multicenter, randomized crossover clinical trial in patients that were expected to need invasive ventilation > 24 hours. Patients were randomly assigned to start with a 3-hour period of automated ventilation or conventional ventilation after which the alternate ventilation mode was selected. The primary outcome was mechanical power in passive and active patients; secondary outcomes included key ventilator settings and ventilatory parameters that affect mechanical power. Results A total of 96 patients were randomized. Median mechanical power was not different between automated and conventional ventilation (15.8 [11.5-21.0] versus 16.1 [10.9-22.6] J/min; mean difference -0.44 (95%-CI -1.17 to 0.29) J/min; P = 0.24). Subgroup analyses showed that mechanical power was lower with automated ventilation in passive patients, 16.9 [12.5-22.1] versus 19.0 [14.1-25.0] J/min; mean difference -1.76 (95%-CI -2.47 to - 10.34J/min; P < 0.01), and not in active patients (14.6 [11.0-20.3] vs 14.1 [10.1-21.3] J/min; mean difference 0.81 (95%-CI -2.13 to 0.49) J/min; P = 0.23). Conclusions In this cohort of unselected critically ill invasively ventilated patients, automated ventilation by means of INTELLiVENT-Adaptive Support Ventilation did not reduce mechanical power. A reduction in mechanical power was only seen in passive patients.