Dysregulated immunologic landscape of the early host response in melioidosis

dc.contributor.authorRongkard P.
dc.contributor.authorXia L.
dc.contributor.authorKronsteiner B.
dc.contributor.authorYimthin T.
dc.contributor.authorPhunpang R.
dc.contributor.authorDulsuk A.
dc.contributor.authorHantrakun V.
dc.contributor.authorWongsuvan G.
dc.contributor.authorChamnan P.
dc.contributor.authorLovelace-Macon L.
dc.contributor.authorMarchi E.
dc.contributor.authorDay N.P.J.
dc.contributor.authorShojaie A.
dc.contributor.authorLimmathurotsakul D.
dc.contributor.authorChantratita N.
dc.contributor.authorKlenerman P.
dc.contributor.authorDunachie S.J.
dc.contributor.authorEoin West T.
dc.contributor.authorGharib S.A.
dc.contributor.correspondenceRongkard P.
dc.contributor.otherMahidol University
dc.date.accessioned2024-10-01T18:11:00Z
dc.date.available2024-10-01T18:11:00Z
dc.date.issued2024-08-20
dc.description.abstractMelioidosis, a neglected tropical infection caused by Burkholderia pseudomallei, commonly presents as pneumonia or sepsis with mortality rates up to 50% despite appropriate treatment. A better understanding of the early host immune response to melioidosis may lead to new therapeutic interventions and prognostication strategies to reduce disease burden. Whole blood transcriptomic signatures in 164 patients with melioidosis and in 70 patients with other infections hospitalized in northeastern Thailand enrolled within 24 hours following hospital admission were studied. Key findings were validated in an independent melioidosis cohort. Melioidosis was characterized by upregulation of interferon (IFN) signaling responses compared with other infections. Mortality in melioidosis was associated with excessive inflammation, enrichment of type 2 immune responses, and a dramatic decrease in T cell-mediated immunity compared with survivors. We identified and independently confirmed a 5-gene predictive set classifying fatal melioidosis (validation cohort area under the receiver operating characteristic curve 0.83; 95% CI, 0.67-0.99). This study highlights the intricate balance between innate and adaptive immunity during fatal melioidosis and can inform future precision medicine strategies for targeted therapies and prognostication in this severe infection.
dc.identifier.citationJCI insight Vol.9 No.18 (2024)
dc.identifier.doi10.1172/jci.insight.179106
dc.identifier.eissn23793708
dc.identifier.pmid39163129
dc.identifier.scopus2-s2.0-85204820244
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/101429
dc.rights.holderSCOPUS
dc.subjectMedicine
dc.titleDysregulated immunologic landscape of the early host response in melioidosis
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85204820244&origin=inward
oaire.citation.issue18
oaire.citation.titleJCI insight
oaire.citation.volume9
oairecerif.author.affiliationMahidol Oxford Tropical Medicine Research Unit
oairecerif.author.affiliationNIHR Oxford Biomedical Research Centre
oairecerif.author.affiliationMichigan State University
oairecerif.author.affiliationUniversity of Washington School of Medicine
oairecerif.author.affiliationUniversity of Washington
oairecerif.author.affiliationMahidol University
oairecerif.author.affiliationNuffield Department of Medicine
oairecerif.author.affiliationSunpasitthiprasong Hospital

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