Evaluating the impact of fluoride toothpaste with and without sodium lauryl sulfate on a human root caries model
2
Issued Date
2026-06-01
Resource Type
eISSN
24058440
Scopus ID
2-s2.0-105038881146
Journal Title
Heliyon
Volume
12
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Heliyon Vol.12 No.10 (2026)
Suggested Citation
Arayapisit T., Wanasuntronwong A., Jitpukdeebodintra S., Rotpenpian N. Evaluating the impact of fluoride toothpaste with and without sodium lauryl sulfate on a human root caries model. Heliyon Vol.12 No.10 (2026). doi:10.1016/j.heliyon.2026.e45037 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116869
Title
Evaluating the impact of fluoride toothpaste with and without sodium lauryl sulfate on a human root caries model
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Abstract
This study aimed to assess the efficacy of fluoride toothpaste containing 1500 ppm fluoride with and without sodium lauryl sulfate (SLS) in preventing root caries in a human root caries model by evaluating fluoride ion disintegration, inhibition of Streptococcus mutans adhesion, and demineralization inhibition. Laboratory experiments involved preparing toothpaste solutions with and without SLS for comparison. Fluoride dissociation was measured using a fluoride ion selective electrode, Streptococcus mutans adhesion inhibition was assessed using a 96-well plate biofilm formation assay, and demineralization properties were compared. Thirty healthy human root dentin samples were divided into five groups and cultured with Streptococcus mutans in a human root caries model for 10 days. There were no statistically significant differences in fluoride dissociation efficiency, inhibition of Streptococcus mutans adhesion, or demineralization inhibition between toothpaste with and without SLS in the human root caries model. Both fluoride toothpastes containing 1500 ppm fluoride with and without SLS showed comparable efficacy in fluoride ion dissociation, demineralization inhibition, and prevention of Streptococcus mutans adhesion.