Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection
Issued Date
2023-12-01
Resource Type
ISSN
07533322
eISSN
19506007
Scopus ID
2-s2.0-85175030390
Journal Title
Biomedicine and Pharmacotherapy
Volume
168
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomedicine and Pharmacotherapy Vol.168 (2023)
Suggested Citation
Shein A.M.S., Wannigama D.L., Hurst C., Monk P.N., Amarasiri M., Badavath V.N., Phattharapornjaroen P., Ditcham W.G.F., Ounjai P., Saethang T., Chantaravisoot N., Thuptimdang W., Luk-in S., Nilgate S., Rirerm U., Tanasatitchai C., Kueakulpattana N., Laowansiri M., Liao T., Kupwiwat R., Rojanathanes R., Ngamwongsatit N., Thammahong A., Ishikawa H., Pletzer D., Leelahavanichkul A., Ragupathi N.K.D., Wapeesittipan P., Ali Hosseini Rad S.M., Kanjanabuch T., Storer R.J., Miyanaga K., Cui L., Hamamoto H., Higgins P.G., Kicic A., Chatsuwan T., Hongsing P., Abe S. Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection. Biomedicine and Pharmacotherapy Vol.168 (2023). doi:10.1016/j.biopha.2023.115793 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90925
Title
Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection
Author(s)
Shein A.M.S.
Wannigama D.L.
Hurst C.
Monk P.N.
Amarasiri M.
Badavath V.N.
Phattharapornjaroen P.
Ditcham W.G.F.
Ounjai P.
Saethang T.
Chantaravisoot N.
Thuptimdang W.
Luk-in S.
Nilgate S.
Rirerm U.
Tanasatitchai C.
Kueakulpattana N.
Laowansiri M.
Liao T.
Kupwiwat R.
Rojanathanes R.
Ngamwongsatit N.
Thammahong A.
Ishikawa H.
Pletzer D.
Leelahavanichkul A.
Ragupathi N.K.D.
Wapeesittipan P.
Ali Hosseini Rad S.M.
Kanjanabuch T.
Storer R.J.
Miyanaga K.
Cui L.
Hamamoto H.
Higgins P.G.
Kicic A.
Chatsuwan T.
Hongsing P.
Abe S.
Wannigama D.L.
Hurst C.
Monk P.N.
Amarasiri M.
Badavath V.N.
Phattharapornjaroen P.
Ditcham W.G.F.
Ounjai P.
Saethang T.
Chantaravisoot N.
Thuptimdang W.
Luk-in S.
Nilgate S.
Rirerm U.
Tanasatitchai C.
Kueakulpattana N.
Laowansiri M.
Liao T.
Kupwiwat R.
Rojanathanes R.
Ngamwongsatit N.
Thammahong A.
Ishikawa H.
Pletzer D.
Leelahavanichkul A.
Ragupathi N.K.D.
Wapeesittipan P.
Ali Hosseini Rad S.M.
Kanjanabuch T.
Storer R.J.
Miyanaga K.
Cui L.
Hamamoto H.
Higgins P.G.
Kicic A.
Chatsuwan T.
Hongsing P.
Abe S.
Author's Affiliation
Yamagata Prefectural Central Hospital
Medizinische Fakultät
Siriraj Hospital
Mae Fah Luang University Hospital
UWA Medical School
Yamagata Prefectural University of Health Sciences
Perth Children's Hospital
Jichi Medical University
The Faculty of Health Sciences
Narsee Monjee Institute of Management Studies, Mumbai
Universitetet i Bergen
Chulalongkorn University
Sahlgrenska Akademin
Yamagata University Faculty of Medicine
Faculty of Medicine, Prince of Songkla University
King Chulalongkorn Memorial Hospital
Kasetsart University
Mae Fah Luang University
University of Otago
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
The Sheffield Medical School
Kitasato University
Charles Darwin University
Faculty of Medicine, Chulalongkorn University
The University of Sheffield
Christian Medical College, Vellore
Telethon Kids Institute
Partner Site Bonn-Cologne
Medizinische Fakultät
Siriraj Hospital
Mae Fah Luang University Hospital
UWA Medical School
Yamagata Prefectural University of Health Sciences
Perth Children's Hospital
Jichi Medical University
The Faculty of Health Sciences
Narsee Monjee Institute of Management Studies, Mumbai
Universitetet i Bergen
Chulalongkorn University
Sahlgrenska Akademin
Yamagata University Faculty of Medicine
Faculty of Medicine, Prince of Songkla University
King Chulalongkorn Memorial Hospital
Kasetsart University
Mae Fah Luang University
University of Otago
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
The Sheffield Medical School
Kitasato University
Charles Darwin University
Faculty of Medicine, Chulalongkorn University
The University of Sheffield
Christian Medical College, Vellore
Telethon Kids Institute
Partner Site Bonn-Cologne
Other Contributor(s)
Abstract
Given the rise of multidrug-resistant (MDR) Pseudomonas aeruginosa infections, alternative treatments are needed. Anti-pseudomonal phage therapy shows promise, but its clinical application is limited due to the development of resistance and a lack of biofilm penetration. Recently, adjuvants like CaEDTA have shown the ability to enhance the effectiveness of combined antimicrobial agents. Here, we tested a phage-adjuvant combination and demonstrated the effectiveness of intranasally inhaled phage (KKP10) + CaEDTA in addition to ceftazidime/avibactam (CZA) for chronic P. aeruginosa lung infections. The results emphasize that intranasal inhalation of phage along with CaEDTA can successfully re-sensitize MDR P. aeruginosa to CZA in a triple combination treatment. This promising approach shows potential as a therapy for chronic respiratory tract infections.
