Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection

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dc.contributor.authorShein A.M.S.
dc.contributor.authorWannigama D.L.
dc.contributor.authorHurst C.
dc.contributor.authorMonk P.N.
dc.contributor.authorAmarasiri M.
dc.contributor.authorBadavath V.N.
dc.contributor.authorPhattharapornjaroen P.
dc.contributor.authorDitcham W.G.F.
dc.contributor.authorOunjai P.
dc.contributor.authorSaethang T.
dc.contributor.authorChantaravisoot N.
dc.contributor.authorThuptimdang W.
dc.contributor.authorLuk-in S.
dc.contributor.authorNilgate S.
dc.contributor.authorRirerm U.
dc.contributor.authorTanasatitchai C.
dc.contributor.authorKueakulpattana N.
dc.contributor.authorLaowansiri M.
dc.contributor.authorLiao T.
dc.contributor.authorKupwiwat R.
dc.contributor.authorRojanathanes R.
dc.contributor.authorNgamwongsatit N.
dc.contributor.authorThammahong A.
dc.contributor.authorIshikawa H.
dc.contributor.authorPletzer D.
dc.contributor.authorLeelahavanichkul A.
dc.contributor.authorRagupathi N.K.D.
dc.contributor.authorWapeesittipan P.
dc.contributor.authorAli Hosseini Rad S.M.
dc.contributor.authorKanjanabuch T.
dc.contributor.authorStorer R.J.
dc.contributor.authorMiyanaga K.
dc.contributor.authorCui L.
dc.contributor.authorHamamoto H.
dc.contributor.authorHiggins P.G.
dc.contributor.authorKicic A.
dc.contributor.authorChatsuwan T.
dc.contributor.authorHongsing P.
dc.contributor.authorAbe S.
dc.contributor.otherMahidol University
dc.date.accessioned2023-11-04T18:02:51Z
dc.date.available2023-11-04T18:02:51Z
dc.date.issued2023-12-01
dc.description.abstractGiven the rise of multidrug-resistant (MDR) Pseudomonas aeruginosa infections, alternative treatments are needed. Anti-pseudomonal phage therapy shows promise, but its clinical application is limited due to the development of resistance and a lack of biofilm penetration. Recently, adjuvants like CaEDTA have shown the ability to enhance the effectiveness of combined antimicrobial agents. Here, we tested a phage-adjuvant combination and demonstrated the effectiveness of intranasally inhaled phage (KKP10) + CaEDTA in addition to ceftazidime/avibactam (CZA) for chronic P. aeruginosa lung infections. The results emphasize that intranasal inhalation of phage along with CaEDTA can successfully re-sensitize MDR P. aeruginosa to CZA in a triple combination treatment. This promising approach shows potential as a therapy for chronic respiratory tract infections.
dc.identifier.citationBiomedicine and Pharmacotherapy Vol.168 (2023)
dc.identifier.doi10.1016/j.biopha.2023.115793
dc.identifier.eissn19506007
dc.identifier.issn07533322
dc.identifier.scopus2-s2.0-85175030390
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/90925
dc.rights.holderSCOPUS
dc.subjectPharmacology, Toxicology and Pharmaceutics
dc.titleNovel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85175030390&origin=inward
oaire.citation.titleBiomedicine and Pharmacotherapy
oaire.citation.volume168
oairecerif.author.affiliationYamagata Prefectural Central Hospital
oairecerif.author.affiliationMedizinische Fakultät
oairecerif.author.affiliationSiriraj Hospital
oairecerif.author.affiliationMae Fah Luang University Hospital
oairecerif.author.affiliationUWA Medical School
oairecerif.author.affiliationYamagata Prefectural University of Health Sciences
oairecerif.author.affiliationPerth Children's Hospital
oairecerif.author.affiliationJichi Medical University
oairecerif.author.affiliationThe Faculty of Health Sciences
oairecerif.author.affiliationNarsee Monjee Institute of Management Studies, Mumbai
oairecerif.author.affiliationUniversitetet i Bergen
oairecerif.author.affiliationChulalongkorn University
oairecerif.author.affiliationSahlgrenska Akademin
oairecerif.author.affiliationYamagata University Faculty of Medicine
oairecerif.author.affiliationFaculty of Medicine, Prince of Songkla University
oairecerif.author.affiliationKing Chulalongkorn Memorial Hospital
oairecerif.author.affiliationKasetsart University
oairecerif.author.affiliationMae Fah Luang University
oairecerif.author.affiliationUniversity of Otago
oairecerif.author.affiliationFaculty of Medicine Ramathibodi Hospital, Mahidol University
oairecerif.author.affiliationMahidol University
oairecerif.author.affiliationThe Sheffield Medical School
oairecerif.author.affiliationKitasato University
oairecerif.author.affiliationCharles Darwin University
oairecerif.author.affiliationFaculty of Medicine, Chulalongkorn University
oairecerif.author.affiliationThe University of Sheffield
oairecerif.author.affiliationChristian Medical College, Vellore
oairecerif.author.affiliationTelethon Kids Institute
oairecerif.author.affiliationPartner Site Bonn-Cologne

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