Prognostication using SpO<inf>2</inf>/FiO<inf>2</inf> in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study
Issued Date
2022-04-01
Resource Type
ISSN
08839441
eISSN
15578615
Scopus ID
2-s2.0-85126317579
Pubmed ID
34872014
Journal Title
Journal of Critical Care
Volume
68
Start Page
31
End Page
37
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Critical Care Vol.68 (2022) , 31-37
Suggested Citation
Roozeman J.P., Mazzinari G., Serpa Neto A., Hollmann M.W., Paulus F., Schultz M.J., Pisani L., Algera A.G., Boers L.S., Bos L.D.J., Botta M., Dongelmans D.A., Hollmann M.W., Horn J., Paulus F., Pillay J., Tsonas A.M., Vlaar A.P.J., Ahuja S., van Akkeren J.P., Algoe C.K., van Amstel R.B., Artigas A., Baur O.L., van de Berg P., van den Berg A.E., Bergmans D.C.J.J., van den Bersselaar D.I., Bertens F.A., Bindels A.J.G.H., de Boer M.M., den Boer S., Bogerd M., Breel J.S., de Bruin H., de Bruin S., Bruna C.L., Buiteman-Kruizinga L.A., Cremer O.L., Determann R.M., Dieperink W., Franke H.S., Galek-Aldridge M.S., de Graaff M.J., Hagens L.A., Haringman J.J., van der Heide S.T., van der Heiden P.L.J., Heijnen N.F.L., Hiel S.J.P., Hoeijmakers L.L., Hol L., Hoogendoorn M.E., van der Horst R., Ie E.L.K., Ivanov D., Juffermans N.P., Kho E., de Klerk E.S., Gemert A.W.M.M.K.v., Koopmans M., Kucukcelebi S., Kuiper M.A., de Lange D.W., van Mourik N., Nijbroek S.G., Onrust M., Oostdijk E.A.N., Pennartz C.J., Pisani L., Purmer I.M., Rettig T.C.D., Roozeman J.P., Schuijt M.T.U., Sleeswijk M.E., Smit M.R., Spronk P.E., Stilma W., Strang A.C., Tuinman P.R., Valk C.M.A., Veen-Schra F.L., Veldhuis L.I., van Velzen P., van der Ven W.H., van Vliet P., van der Voort P.H.J., van Welie L., Wesselink H.J.F.T., van der Wier-Lubbers H.H., van Wijk B., Winters T., Wong W.Y., van Zanten A.R.H. Prognostication using SpO<inf>2</inf>/FiO<inf>2</inf> in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study. Journal of Critical Care Vol.68 (2022) , 31-37. 37. doi:10.1016/j.jcrc.2021.11.009 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85991
Title
Prognostication using SpO<inf>2</inf>/FiO<inf>2</inf> in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study
Author(s)
Roozeman J.P.
Mazzinari G.
Serpa Neto A.
Hollmann M.W.
Paulus F.
Schultz M.J.
Pisani L.
Algera A.G.
Boers L.S.
Bos L.D.J.
Botta M.
Dongelmans D.A.
Hollmann M.W.
Horn J.
Paulus F.
Pillay J.
Tsonas A.M.
Vlaar A.P.J.
Ahuja S.
van Akkeren J.P.
Algoe C.K.
van Amstel R.B.
Artigas A.
Baur O.L.
van de Berg P.
van den Berg A.E.
Bergmans D.C.J.J.
van den Bersselaar D.I.
Bertens F.A.
Bindels A.J.G.H.
de Boer M.M.
den Boer S.
Bogerd M.
Breel J.S.
de Bruin H.
de Bruin S.
Bruna C.L.
Buiteman-Kruizinga L.A.
Cremer O.L.
Determann R.M.
Dieperink W.
Franke H.S.
Galek-Aldridge M.S.
de Graaff M.J.
Hagens L.A.
Haringman J.J.
van der Heide S.T.
van der Heiden P.L.J.
Heijnen N.F.L.
Hiel S.J.P.
Hoeijmakers L.L.
Hol L.
Hoogendoorn M.E.
van der Horst R.
Ie E.L.K.
Ivanov D.
Juffermans N.P.
Kho E.
de Klerk E.S.
Gemert A.W.M.M.K.v.
Koopmans M.
Kucukcelebi S.
Kuiper M.A.
de Lange D.W.
van Mourik N.
Nijbroek S.G.
Onrust M.
Oostdijk E.A.N.
Pennartz C.J.
Pisani L.
Purmer I.M.
Rettig T.C.D.
Roozeman J.P.
Schuijt M.T.U.
Sleeswijk M.E.
Smit M.R.
Spronk P.E.
Stilma W.
Strang A.C.
Tuinman P.R.
Valk C.M.A.
Veen-Schra F.L.
Veldhuis L.I.
van Velzen P.
van der Ven W.H.
van Vliet P.
van der Voort P.H.J.
van Welie L.
Wesselink H.J.F.T.
van der Wier-Lubbers H.H.
van Wijk B.
Winters T.
Wong W.Y.
van Zanten A.R.H.
Mazzinari G.
Serpa Neto A.
Hollmann M.W.
Paulus F.
Schultz M.J.
Pisani L.
Algera A.G.
Boers L.S.
Bos L.D.J.
Botta M.
Dongelmans D.A.
Hollmann M.W.
Horn J.
Paulus F.
Pillay J.
Tsonas A.M.
Vlaar A.P.J.
Ahuja S.
van Akkeren J.P.
Algoe C.K.
van Amstel R.B.
Artigas A.
Baur O.L.
van de Berg P.
van den Berg A.E.
Bergmans D.C.J.J.
van den Bersselaar D.I.
Bertens F.A.
Bindels A.J.G.H.
de Boer M.M.
den Boer S.
Bogerd M.
Breel J.S.
de Bruin H.
de Bruin S.
Bruna C.L.
Buiteman-Kruizinga L.A.
Cremer O.L.
Determann R.M.
Dieperink W.
Franke H.S.
Galek-Aldridge M.S.
de Graaff M.J.
Hagens L.A.
Haringman J.J.
van der Heide S.T.
van der Heiden P.L.J.
Heijnen N.F.L.
Hiel S.J.P.
Hoeijmakers L.L.
Hol L.
Hoogendoorn M.E.
van der Horst R.
Ie E.L.K.
Ivanov D.
Juffermans N.P.
Kho E.
de Klerk E.S.
Gemert A.W.M.M.K.v.
Koopmans M.
Kucukcelebi S.
Kuiper M.A.
de Lange D.W.
van Mourik N.
Nijbroek S.G.
Onrust M.
Oostdijk E.A.N.
Pennartz C.J.
Pisani L.
Purmer I.M.
Rettig T.C.D.
Roozeman J.P.
Schuijt M.T.U.
Sleeswijk M.E.
Smit M.R.
Spronk P.E.
Stilma W.
Strang A.C.
Tuinman P.R.
Valk C.M.A.
Veen-Schra F.L.
Veldhuis L.I.
van Velzen P.
van der Ven W.H.
van Vliet P.
van der Voort P.H.J.
van Welie L.
Wesselink H.J.F.T.
van der Wier-Lubbers H.H.
van Wijk B.
Winters T.
Wong W.Y.
van Zanten A.R.H.
Author's Affiliation
Maasstad Ziekenhuis
Mahidol Oxford Tropical Medicine Research Unit
Hogeschool van Amsterdam, University of Applied Sciences
Gelre Ziekenhuizen
Maxima Medical Center, Veldhoven
Amphia Hospital
Medisch Centrum Leeuwarden
HagaZiekenhuis
University Medical Center Utrecht
Hospital Universitari i Politècnic La Fe
Catharina Ziekenhuis
Henry Ford Health System
Gelderland Valley Hospital
HMC
St. Antonius Ziekenhuis
OLVG
Università degli studi di Bari Aldo Moro
Monash University
Hospital Israelita Albert Einstein
Rijnstate Hospital
Spaarne Hospital
Nuffield Department of Medicine
Hospital de Sabadell
Maastricht Universitair Medisch Centrum+
Universitair Medisch Centrum Groningen
Isala Clinics
Amsterdam UMC - University of Amsterdam
Reinier de Graaf Hospital - SSDZ
Zuyderland Medical Center
Dijklander Hospital
Flevo Hospital
Instituto de investigación Sanitaria
General Regional Hospital F. Miulli
ZGT Hospital
Mahidol Oxford Tropical Medicine Research Unit
Hogeschool van Amsterdam, University of Applied Sciences
Gelre Ziekenhuizen
Maxima Medical Center, Veldhoven
Amphia Hospital
Medisch Centrum Leeuwarden
HagaZiekenhuis
University Medical Center Utrecht
Hospital Universitari i Politècnic La Fe
Catharina Ziekenhuis
Henry Ford Health System
Gelderland Valley Hospital
HMC
St. Antonius Ziekenhuis
OLVG
Università degli studi di Bari Aldo Moro
Monash University
Hospital Israelita Albert Einstein
Rijnstate Hospital
Spaarne Hospital
Nuffield Department of Medicine
Hospital de Sabadell
Maastricht Universitair Medisch Centrum+
Universitair Medisch Centrum Groningen
Isala Clinics
Amsterdam UMC - University of Amsterdam
Reinier de Graaf Hospital - SSDZ
Zuyderland Medical Center
Dijklander Hospital
Flevo Hospital
Instituto de investigación Sanitaria
General Regional Hospital F. Miulli
ZGT Hospital
Other Contributor(s)
Abstract
Background: The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID–19. Methods: This was a post-hoc analysis of a national multicenter cohort study in invasively ventilated patients with ARDS due to COVID–19. The primary endpoint was 28–day mortality. Results: In 869 invasively ventilated patients, 28–day mortality was 30.1%. The SpO2/FiO2 on day 1 had no prognostic value. The SpO2/FiO2 on day 2 and day 3 had prognostic capacity for death, with the best cut-offs being 179 and 199, respectively. Both SpO2/FiO2 on day 2 (OR, 0.66 [95%–CI 0.46–0.96]) and on day 3 (OR, 0.70 [95%–CI 0.51–0.96]) were associated with 28–day mortality in a model corrected for age, pH, lactate levels and kidney dysfunction (AUROC 0.78 [0.76–0.79]). The measured PaO2/FiO2 and the PaO2/FiO2 calculated from SpO2/FiO2 were strongly correlated (Spearman's r = 0.79). Conclusions: In this cohort of patients with ARDS due to COVID–19, the SpO2/FiO2 on day 2 and day 3 are independently associated with and have prognostic capacity for 28–day mortality. The SpO2/FiO2 is a useful metric for risk stratification in invasively ventilated COVID–19 patients.