Prognostication using SpO<inf>2</inf>/FiO<inf>2</inf> in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

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dc.contributor.authorRoozeman J.P.
dc.contributor.authorMazzinari G.
dc.contributor.authorSerpa Neto A.
dc.contributor.authorHollmann M.W.
dc.contributor.authorPaulus F.
dc.contributor.authorSchultz M.J.
dc.contributor.authorPisani L.
dc.contributor.authorAlgera A.G.
dc.contributor.authorBoers L.S.
dc.contributor.authorBos L.D.J.
dc.contributor.authorBotta M.
dc.contributor.authorDongelmans D.A.
dc.contributor.authorHollmann M.W.
dc.contributor.authorHorn J.
dc.contributor.authorPaulus F.
dc.contributor.authorPillay J.
dc.contributor.authorTsonas A.M.
dc.contributor.authorVlaar A.P.J.
dc.contributor.authorAhuja S.
dc.contributor.authorvan Akkeren J.P.
dc.contributor.authorAlgoe C.K.
dc.contributor.authorvan Amstel R.B.
dc.contributor.authorArtigas A.
dc.contributor.authorBaur O.L.
dc.contributor.authorvan de Berg P.
dc.contributor.authorvan den Berg A.E.
dc.contributor.authorBergmans D.C.J.J.
dc.contributor.authorvan den Bersselaar D.I.
dc.contributor.authorBertens F.A.
dc.contributor.authorBindels A.J.G.H.
dc.contributor.authorde Boer M.M.
dc.contributor.authorden Boer S.
dc.contributor.authorBogerd M.
dc.contributor.authorBreel J.S.
dc.contributor.authorde Bruin H.
dc.contributor.authorde Bruin S.
dc.contributor.authorBruna C.L.
dc.contributor.authorBuiteman-Kruizinga L.A.
dc.contributor.authorCremer O.L.
dc.contributor.authorDetermann R.M.
dc.contributor.authorDieperink W.
dc.contributor.authorFranke H.S.
dc.contributor.authorGalek-Aldridge M.S.
dc.contributor.authorde Graaff M.J.
dc.contributor.authorHagens L.A.
dc.contributor.authorHaringman J.J.
dc.contributor.authorvan der Heide S.T.
dc.contributor.authorvan der Heiden P.L.J.
dc.contributor.authorHeijnen N.F.L.
dc.contributor.authorHiel S.J.P.
dc.contributor.authorHoeijmakers L.L.
dc.contributor.authorHol L.
dc.contributor.authorHoogendoorn M.E.
dc.contributor.authorvan der Horst R.
dc.contributor.authorIe E.L.K.
dc.contributor.authorIvanov D.
dc.contributor.authorJuffermans N.P.
dc.contributor.authorKho E.
dc.contributor.authorde Klerk E.S.
dc.contributor.authorGemert A.W.M.M.K.v.
dc.contributor.authorKoopmans M.
dc.contributor.authorKucukcelebi S.
dc.contributor.authorKuiper M.A.
dc.contributor.authorde Lange D.W.
dc.contributor.authorvan Mourik N.
dc.contributor.authorNijbroek S.G.
dc.contributor.authorOnrust M.
dc.contributor.authorOostdijk E.A.N.
dc.contributor.authorPennartz C.J.
dc.contributor.authorPisani L.
dc.contributor.authorPurmer I.M.
dc.contributor.authorRettig T.C.D.
dc.contributor.authorRoozeman J.P.
dc.contributor.authorSchuijt M.T.U.
dc.contributor.authorSleeswijk M.E.
dc.contributor.authorSmit M.R.
dc.contributor.authorSpronk P.E.
dc.contributor.authorStilma W.
dc.contributor.authorStrang A.C.
dc.contributor.authorTuinman P.R.
dc.contributor.authorValk C.M.A.
dc.contributor.authorVeen-Schra F.L.
dc.contributor.authorVeldhuis L.I.
dc.contributor.authorvan Velzen P.
dc.contributor.authorvan der Ven W.H.
dc.contributor.authorvan Vliet P.
dc.contributor.authorvan der Voort P.H.J.
dc.contributor.authorvan Welie L.
dc.contributor.authorWesselink H.J.F.T.
dc.contributor.authorvan der Wier-Lubbers H.H.
dc.contributor.authorvan Wijk B.
dc.contributor.authorWinters T.
dc.contributor.authorWong W.Y.
dc.contributor.authorvan Zanten A.R.H.
dc.contributor.otherMahidol University
dc.date.accessioned2023-06-18T17:52:56Z
dc.date.available2023-06-18T17:52:56Z
dc.date.issued2022-04-01
dc.description.abstractBackground: The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID–19. Methods: This was a post-hoc analysis of a national multicenter cohort study in invasively ventilated patients with ARDS due to COVID–19. The primary endpoint was 28–day mortality. Results: In 869 invasively ventilated patients, 28–day mortality was 30.1%. The SpO2/FiO2 on day 1 had no prognostic value. The SpO2/FiO2 on day 2 and day 3 had prognostic capacity for death, with the best cut-offs being 179 and 199, respectively. Both SpO2/FiO2 on day 2 (OR, 0.66 [95%–CI 0.46–0.96]) and on day 3 (OR, 0.70 [95%–CI 0.51–0.96]) were associated with 28–day mortality in a model corrected for age, pH, lactate levels and kidney dysfunction (AUROC 0.78 [0.76–0.79]). The measured PaO2/FiO2 and the PaO2/FiO2 calculated from SpO2/FiO2 were strongly correlated (Spearman's r = 0.79). Conclusions: In this cohort of patients with ARDS due to COVID–19, the SpO2/FiO2 on day 2 and day 3 are independently associated with and have prognostic capacity for 28–day mortality. The SpO2/FiO2 is a useful metric for risk stratification in invasively ventilated COVID–19 patients.
dc.identifier.citationJournal of Critical Care Vol.68 (2022) , 31-37
dc.identifier.doi10.1016/j.jcrc.2021.11.009
dc.identifier.eissn15578615
dc.identifier.issn08839441
dc.identifier.pmid34872014
dc.identifier.scopus2-s2.0-85126317579
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/85991
dc.rights.holderSCOPUS
dc.subjectMedicine
dc.titlePrognostication using SpO<inf>2</inf>/FiO<inf>2</inf> in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85126317579&origin=inward
oaire.citation.endPage37
oaire.citation.startPage31
oaire.citation.titleJournal of Critical Care
oaire.citation.volume68
oairecerif.author.affiliationMaasstad Ziekenhuis
oairecerif.author.affiliationMahidol Oxford Tropical Medicine Research Unit
oairecerif.author.affiliationHogeschool van Amsterdam, University of Applied Sciences
oairecerif.author.affiliationGelre Ziekenhuizen
oairecerif.author.affiliationMaxima Medical Center, Veldhoven
oairecerif.author.affiliationAmphia Hospital
oairecerif.author.affiliationMedisch Centrum Leeuwarden
oairecerif.author.affiliationHagaZiekenhuis
oairecerif.author.affiliationUniversity Medical Center Utrecht
oairecerif.author.affiliationHospital Universitari i Politècnic La Fe
oairecerif.author.affiliationCatharina Ziekenhuis
oairecerif.author.affiliationHenry Ford Health System
oairecerif.author.affiliationGelderland Valley Hospital
oairecerif.author.affiliationHMC
oairecerif.author.affiliationSt. Antonius Ziekenhuis
oairecerif.author.affiliationOLVG
oairecerif.author.affiliationUniversità degli studi di Bari Aldo Moro
oairecerif.author.affiliationMonash University
oairecerif.author.affiliationHospital Israelita Albert Einstein
oairecerif.author.affiliationRijnstate Hospital
oairecerif.author.affiliationSpaarne Hospital
oairecerif.author.affiliationNuffield Department of Medicine
oairecerif.author.affiliationHospital de Sabadell
oairecerif.author.affiliationMaastricht Universitair Medisch Centrum+
oairecerif.author.affiliationUniversitair Medisch Centrum Groningen
oairecerif.author.affiliationIsala Clinics
oairecerif.author.affiliationAmsterdam UMC - University of Amsterdam
oairecerif.author.affiliationReinier de Graaf Hospital - SSDZ
oairecerif.author.affiliationZuyderland Medical Center
oairecerif.author.affiliationDijklander Hospital
oairecerif.author.affiliationFlevo Hospital
oairecerif.author.affiliationInstituto de investigación Sanitaria
oairecerif.author.affiliationGeneral Regional Hospital F. Miulli
oairecerif.author.affiliationZGT Hospital

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