Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
Issued Date
2022-06-01
Resource Type
ISSN
03065251
eISSN
13652125
Scopus ID
2-s2.0-85123687526
Pubmed ID
34997616
Journal Title
British Journal of Clinical Pharmacology
Volume
88
Issue
6
Start Page
2657
End Page
2664
Rights Holder(s)
SCOPUS
Bibliographic Citation
British Journal of Clinical Pharmacology Vol.88 No.6 (2022) , 2657-2664
Suggested Citation
White N.J., Watson J.A., Baird J.K. Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials. British Journal of Clinical Pharmacology Vol.88 No.6 (2022) , 2657-2664. 2664. doi:10.1111/bcp.15219 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85854
Title
Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
Author(s)
Other Contributor(s)
Abstract
Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and Plasmodium ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.