Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials

Simple item page
dc.contributor.authorWhite N.J.
dc.contributor.authorWatson J.A.
dc.contributor.authorBaird J.K.
dc.contributor.otherMahidol University
dc.date.accessioned2023-06-18T17:50:11Z
dc.date.available2023-06-18T17:50:11Z
dc.date.issued2022-06-01
dc.description.abstractMethaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and Plasmodium ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.
dc.identifier.citationBritish Journal of Clinical Pharmacology Vol.88 No.6 (2022) , 2657-2664
dc.identifier.doi10.1111/bcp.15219
dc.identifier.eissn13652125
dc.identifier.issn03065251
dc.identifier.pmid34997616
dc.identifier.scopus2-s2.0-85123687526
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/85854
dc.rights.holderSCOPUS
dc.subjectMedicine
dc.titleMethaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
dc.typeReview
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123687526&origin=inward
oaire.citation.endPage2664
oaire.citation.issue6
oaire.citation.startPage2657
oaire.citation.titleBritish Journal of Clinical Pharmacology
oaire.citation.volume88
oairecerif.author.affiliationFaculty of Tropical Medicine, Mahidol University
oairecerif.author.affiliationEijkman Institute for Molecular Biology
oairecerif.author.affiliationNuffield Department of Medicine

Files

Collections

Scopus 2022