The atypical faces of optic neuritis: neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease

dc.contributor.authorPoonja S.
dc.contributor.authorRattanathamsakul N.
dc.contributor.authorChen J.J.
dc.contributor.correspondencePoonja S.
dc.contributor.otherMahidol University
dc.date.accessioned2024-12-10T18:25:50Z
dc.date.available2024-12-10T18:25:50Z
dc.date.issued2024-01-01
dc.description.abstractPurpose of review The purpose of this article is to provide a review of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), with a focus on what renders optic neuritis "atypical" in these two conditions. Clinical features, diagnostic criteria, and epidemiology are outlined. Acute treatments for optic neuritis, as well as immunotherapy for NMOSD and MOGAD are discussed. Recent findings Updates in NMOSD and MOGAD are highlighted, with an emphasis on novel work including the new 2023 MOGAD diagnostic criteria, our evolving understanding on the epidemiology of these conditions, and recently FDA-approved NMOSD treatments. Pipeline therapies are also discussed. Summary A thorough history and examination, supported by ancillary testing, continues to be the mainstay of optic neuritis diagnosis. Stratifying typical versus atypical optic neuritis is paramount. Within the atypical category, NMOSD and MOGAD are important considerations. Clues can point towards these diagnoses and guide steps for treatment, which is increasingly becoming targeted to individual diseases, as the pathophysiology is different for these disorders.
dc.identifier.citationCurrent Opinion in Neurology (2024)
dc.identifier.doi10.1097/WCO.0000000000001335
dc.identifier.eissn14736551
dc.identifier.issn13507540
dc.identifier.pmid39564614
dc.identifier.scopus2-s2.0-85210767721
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/102336
dc.rights.holderSCOPUS
dc.subjectNeuroscience
dc.subjectMedicine
dc.titleThe atypical faces of optic neuritis: neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease
dc.typeReview
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85210767721&origin=inward
oaire.citation.titleCurrent Opinion in Neurology
oairecerif.author.affiliationSiriraj Hospital
oairecerif.author.affiliationMayo Clinic

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