Hemoperfusion adsorbents from porous PMMA microspheres: synthesis approaches and their cytokine removal efficiency
Issued Date
2025-10-08
Resource Type
ISSN
2050750X
eISSN
20507518
Scopus ID
2-s2.0-105018034966
Journal Title
Journal of Materials Chemistry B
Volume
13
Issue
39
Start Page
12614
End Page
12623
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Materials Chemistry B Vol.13 No.39 (2025) , 12614-12623
Suggested Citation
Phasuk A., Putthabucha N., Winuprasith T., Srisawat N., Khomein P. Hemoperfusion adsorbents from porous PMMA microspheres: synthesis approaches and their cytokine removal efficiency. Journal of Materials Chemistry B Vol.13 No.39 (2025) , 12614-12623. 12623. doi:10.1039/d5tb01570g Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112619
Title
Hemoperfusion adsorbents from porous PMMA microspheres: synthesis approaches and their cytokine removal efficiency
Corresponding Author(s)
Other Contributor(s)
Abstract
The renewed interest in hemoperfusion for extracorporeal blood purification has spurred extensive research into the development of new potential adsorbents. In this study, the potential of polymethyl methacrylate (PMMA) as a hemoperfusion adsorbent was explored. An approach to prepare a suitable adsorbent from PMMA was developed. Porous PMMA microspheres with a size over 300 μm and a high specific surface area were prepared with the ability to tune their pore structure by changing the porogen concentration. Hemocompatibility was thoroughly evaluated to assess their suitability for direct blood-contact hemoperfusion applications. The newly developed porous PMMA microspheres demonstrated effective removal of representative cytokines (MCP-1 and IL-6) with different molecular weights and net charges at physiological pH, achieving approximately 80% removal efficiency. These results highlight their strong potential as hemoperfusion adsorbents.