Head and Neck Cancer in Southeast Asia: 2022 Incidence, Mortality, and Projections to 2050
7
Issued Date
2025-01-01
Resource Type
ISSN
0023852X
eISSN
15314995
Scopus ID
2-s2.0-105011818780
Journal Title
Laryngoscope
Rights Holder(s)
SCOPUS
Bibliographic Citation
Laryngoscope (2025)
Suggested Citation
Chen J., Selokar A., Ho F.D.V., Jacomina L.E., Feliciano E.J.G., Uy J.M.A.d.L., Wu J.F., Jain U., Jain B., Columbres R.C., Treechairusame T., Willmann J., Ting F.I.L., Iyengar P., Moraes F.Y., Gyawali B., Tangco E.D., Flores J.A., Chua M.L.K., Estilo C., Mejia M.B.A., Lee N.Y., Dee E.C. Head and Neck Cancer in Southeast Asia: 2022 Incidence, Mortality, and Projections to 2050. Laryngoscope (2025). doi:10.1002/lary.32450 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111515
Title
Head and Neck Cancer in Southeast Asia: 2022 Incidence, Mortality, and Projections to 2050
Author's Affiliation
Universidade de São Paulo
University of California, San Diego
Stanford University School of Medicine
Icahn School of Medicine at Mount Sinai
University of Pittsburgh School of Medicine
National Cancer Institute (NCI)
Queen’s University
Memorial Sloan-Kettering Cancer Center
Medical College of Wisconsin
UniversitatsSpital Zurich
Duke-NUS Medical School
Siriraj Hospital
Ateneo de Manila University
University of the Philippines College of Medicine
University of Santo Tomas Hospital
WCU College of Osteopathic Medicine
Jose R. Reyes Memorial Medical Center
University of St. La Salle
The Medical City
Corazon Locsin Montelibano Memorial Regional Hospital
University of California, San Diego
Stanford University School of Medicine
Icahn School of Medicine at Mount Sinai
University of Pittsburgh School of Medicine
National Cancer Institute (NCI)
Queen’s University
Memorial Sloan-Kettering Cancer Center
Medical College of Wisconsin
UniversitatsSpital Zurich
Duke-NUS Medical School
Siriraj Hospital
Ateneo de Manila University
University of the Philippines College of Medicine
University of Santo Tomas Hospital
WCU College of Osteopathic Medicine
Jose R. Reyes Memorial Medical Center
University of St. La Salle
The Medical City
Corazon Locsin Montelibano Memorial Regional Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Objectives: To characterize the incidence, mortality, and disparities in head and neck cancer (HNC) across Southeast Asia (SEA) in 2022 and project trends to 2050 to inform cancer planning. Methods: We conducted a population-based analysis using 2022 Global Cancer Observatory data from 11 SEA countries. We analyzed cancers of the lip and oral cavity, salivary glands, oropharynx, nasopharynx, hypopharynx, larynx, and thyroid. Age-standardized incidence and mortality rates (ASIR and ASMR) were calculated using the Segi-Doll world standard. Projections to 2050 were based on demographic changes using UN World Population Prospects data, assuming stable incidence and mortality rates. Results: Myanmar had the highest oral cancer rates (ASIR: 6.6 males, 2.6 females; ASMR: 3.9 males, 1.6 females). Elevated salivary gland cancer incidence was observed in Indonesia, the Philippines, and Singapore. Oropharyngeal cancers showed strong male predominance in Myanmar (ASIR ratio: 10:1). Nasopharyngeal cancer incidence in Brunei and Indonesia exceeded global averages (ASIR: 9.8 and 9.6 males). Projections to 2050 estimate 47,000 new male cases and 28,200 new female cases in Indonesia, with 30,600 male deaths and 12,200 female deaths. While SEA's overall ASIR for HNC (18.0) was comparable to the global average (18.9), the ASMR was significantly higher (9.5 vs. 5.3). Conclusions: The rising burden of HNC in SEA highlights urgent disparities in incidence and mortality. Targeted prevention, early detection, and investment in cancer care systems are essential to mitigate future disease burden and improve outcomes. Level of Evidence: Level III—Epidemiologic study using population-based registry data.