Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais
Issued Date
2023-05-01
Resource Type
eISSN
20726643
Scopus ID
2-s2.0-85159103147
Journal Title
Nutrients
Volume
15
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nutrients Vol.15 No.9 (2023)
Suggested Citation
Promyos N., Phienluphon P.P., Wechjakwen N., Lainampetch J., Prangthip P., Kwanbunjan K. Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais. Nutrients Vol.15 No.9 (2023). doi:10.3390/nu15092071 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82809
Title
Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais
Other Contributor(s)
Abstract
Oxidative stress contributes to defective antioxidant defenses, which may lead to type 2 diabetes (T2D). This study aimed to elucidate the T2D risks and antioxidant defenses by investigating the superoxide dismutase (SOD), catalase (CAT), vitamin A, and vitamin E status. We observed 102 participants aged 35–66 years from Sung Neon, Nakhon Ratchasima, Thailand. The blood samples were collected to measure the SOD, CAT, vitamin A, and vitamin E concentrations. The SOD and CAT activities were inversely associated with T2D risk. When compared with participants in the highest quartile of SOD and CAT, those in the lowest quartile for T2D risk obtained multivariable-adjusted odds ratios of 4.77 (SOD: 95% confident interval CI, 1.01–22.40; p = 0.047) and 4.22 (CAT: 95% CI, 1.07–16.60; p = 0.039). The possible influencing factors (e.g., physical activity, total cholesterol, and triglyceride) might mediate the association of SOD and CAT with T2D risk. Meanwhile, the relationship between vitamin A and vitamin E concentrations and T2D risk was insignificant. In conclusion, lower concentrations of antioxidant enzyme activity (SOD and CAT) may be an additional risk factor for T2D.