Mimicking scaffold membrane based electrospun polyurethane fibers with functional extracellular-like component coating for guided bone regeneration scaffolds
Issued Date
2025-09-01
Resource Type
eISSN
26665344
Scopus ID
2-s2.0-105013498323
Journal Title
Biomaterials and Biosystems
Volume
19
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomaterials and Biosystems Vol.19 (2025)
Suggested Citation
Watcharajittanont N., Prarokijjak W., Teanchai C., Jatuworapruk K., Meesane J. Mimicking scaffold membrane based electrospun polyurethane fibers with functional extracellular-like component coating for guided bone regeneration scaffolds. Biomaterials and Biosystems Vol.19 (2025). doi:10.1016/j.bbiosy.2025.100116 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111746
Title
Mimicking scaffold membrane based electrospun polyurethane fibers with functional extracellular-like component coating for guided bone regeneration scaffolds
Corresponding Author(s)
Other Contributor(s)
Abstract
Mimicking scaffold membranes for guided bone regeneration were fabricated using electrospun polyurethane (PU) coated with polyvinyl alcohol (PVA) and sodium alginate. Five different proportions of PVA and sodium alginate (AGN) were compared as coating solutions for the electrospun PU membranes. Molecular organization, morphology, and physical, mechanical, and biological properties were investigated. The results demonstrated that the electro-spun PU membranes with PVA and sodium alginate coating showed molecular organization via chemical bonding. The coated membranes, especially PU/PVA:AGN (30:70), exhibited higher hydrophilicity, maximum load, and elasticity than membranes without coating, and they exhibited better cell adhesion, cell proliferation, ALP activity, and calcium deposition. In conclusion, we determined that our PU/PVA:AGN (30:70) periosteum mimicking membrane is a promising candidate for guided bone regeneration applications.