Mimicking scaffold membrane based electrospun polyurethane fibers with functional extracellular-like component coating for guided bone regeneration scaffolds

Abstract

Mimicking scaffold membranes for guided bone regeneration were fabricated using electrospun polyurethane (PU) coated with polyvinyl alcohol (PVA) and sodium alginate. Five different proportions of PVA and sodium alginate (AGN) were compared as coating solutions for the electrospun PU membranes. Molecular organization, morphology, and physical, mechanical, and biological properties were investigated. The results demonstrated that the electro-spun PU membranes with PVA and sodium alginate coating showed molecular organization via chemical bonding. The coated membranes, especially PU/PVA:AGN (30:70), exhibited higher hydrophilicity, maximum load, and elasticity than membranes without coating, and they exhibited better cell adhesion, cell proliferation, ALP activity, and calcium deposition. In conclusion, we determined that our PU/PVA:AGN (30:70) periosteum mimicking membrane is a promising candidate for guided bone regeneration applications.