Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus
2
Issued Date
2023-11-24
Resource Type
eISSN
15237052
Scopus ID
2-s2.0-85178495204
Pubmed ID
37902783
Journal Title
Organic letters
Volume
25
Issue
46
Start Page
8183
End Page
8187
Rights Holder(s)
SCOPUS
Bibliographic Citation
Organic letters Vol.25 No.46 (2023) , 8183-8187
Suggested Citation
Sawektreeratana N., Krachangchaeng C., Pittayanurak P., Betterley N.M., Chairoungdua A., Wongpan A., Panvongsa W., Janthakit P., Nalaoh P., Promarak V., Nuntasaen N., Reutrakul V., Kuhakarn C., Hongthong S. Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus. Organic letters Vol.25 No.46 (2023) , 8183-8187. 8187. doi:10.1021/acs.orglett.3c02641 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/91432
Title
Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus
Other Contributor(s)
Abstract
The structures of potent cytotoxic cycloheptapeptides, mallotumides A-C (1-3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC50 values ranging from 0.60 to 4.02 nM.