Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus

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dc.contributor.authorSawektreeratana N.
dc.contributor.authorKrachangchaeng C.
dc.contributor.authorPittayanurak P.
dc.contributor.authorBetterley N.M.
dc.contributor.authorChairoungdua A.
dc.contributor.authorWongpan A.
dc.contributor.authorPanvongsa W.
dc.contributor.authorJanthakit P.
dc.contributor.authorNalaoh P.
dc.contributor.authorPromarak V.
dc.contributor.authorNuntasaen N.
dc.contributor.authorReutrakul V.
dc.contributor.authorKuhakarn C.
dc.contributor.authorHongthong S.
dc.contributor.otherMahidol University
dc.date.accessioned2023-12-12T18:01:20Z
dc.date.available2023-12-12T18:01:20Z
dc.date.issued2023-11-24
dc.description.abstractThe structures of potent cytotoxic cycloheptapeptides, mallotumides A-C (1-3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC50 values ranging from 0.60 to 4.02 nM.
dc.identifier.citationOrganic letters Vol.25 No.46 (2023) , 8183-8187
dc.identifier.doi10.1021/acs.orglett.3c02641
dc.identifier.eissn15237052
dc.identifier.pmid37902783
dc.identifier.scopus2-s2.0-85178495204
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/91432
dc.rights.holderSCOPUS
dc.subjectChemistry
dc.titleMallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85178495204&origin=inward
oaire.citation.endPage8187
oaire.citation.issue46
oaire.citation.startPage8183
oaire.citation.titleOrganic letters
oaire.citation.volume25
oairecerif.author.affiliationFaculty of Tropical Medicine, Mahidol University
oairecerif.author.affiliationRajabhat Rajanagarindra University
oairecerif.author.affiliationVidyasirimedhi Institute of Science and Technology
oairecerif.author.affiliationThe University of Tennessee, Knoxville

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