Study on toxicogenesis of T-2 toxin
2
Issued Date
1987
Copyright Date
1987
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xiii, 111 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Toxicology))--Mahidol University, 1987
Suggested Citation
Suwanit Suwannavong Study on toxicogenesis of T-2 toxin. Thesis (M.Sc. (Toxicology))--Mahidol University, 1987. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103437
Title
Study on toxicogenesis of T-2 toxin
Alternative Title(s)
การศึกษากลไกการเกิดพิษของสารพิษ T-2
Author(s)
Advisor(s)
Abstract
revealed an increase of vital dye stained cells, the leakage of LDH into incubation medium and the decrease in cellular level of ATP concomitantly with the increased ADP and AMP levels. This evidence also supported by the decreased energy charge in T-2 treated AS30D cell. These cytotoxicities in duced by T-2 toxin could effectively be prevented by isoptin at all calcium concentrations studied. In the animal, T-2 toxin significantly induced an increase in calcium uptake to the skin exposed to T-2 toxin topically. This effect could effectively be reduced by either isoptin or dexamethasone. The result obtained indicated at least 2 concerted mechanisms involving in the toxicity of T-2 toxin. The calcium dependent cytotoxicity that could effectively be prevented by isoptin and the calcium independent cytotoxic effect. The precise mechanism remains to be further elucidated.
Description
Toxicology (Mahidol University 1987)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Toxicology
Degree Grantor(s)
Mahidol University