Antiparasitic effect of peptoids against Cryptosporidium parvum

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dc.contributor.authorLamont B.
dc.contributor.authorRussell B.M.
dc.contributor.authorSuwanarusk R.
dc.contributor.authorNielsen J.E.
dc.contributor.authorSørensen K.
dc.contributor.authorYung D.
dc.contributor.authorBarron A.E.
dc.contributor.authorPletzer D.
dc.contributor.authorMuhsin-Sharafaldine M.R.
dc.contributor.correspondenceLamont B.
dc.contributor.otherMahidol University
dc.date.accessioned2025-10-20T18:14:16Z
dc.date.available2025-10-20T18:14:16Z
dc.date.issued2025-10-01
dc.description.abstractCryptosporidiosis, caused by Cryptosporidium parvum, poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable groups. This study explores the antiparasitic effects of peptoids against C. parvum. Out of 14 synthetic peptidomimetics (peptoids) screened, TM9 and TM19 exhibited potent anti-cryptosporidial activity with minimal host toxicity. These findings suggest that peptoids could be a promising new therapeutic avenue for cryptosporidiosis, warranting further investigation.
dc.identifier.citationMicrobiology Reading England Vol.171 No.10 (2025)
dc.identifier.doi10.1099/mic.0.001607
dc.identifier.eissn14652080
dc.identifier.pmid41082282
dc.identifier.scopus2-s2.0-105018527741
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/112667
dc.rights.holderSCOPUS
dc.subjectImmunology and Microbiology
dc.titleAntiparasitic effect of peptoids against Cryptosporidium parvum
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105018527741&origin=inward
oaire.citation.issue10
oaire.citation.titleMicrobiology Reading England
oaire.citation.volume171
oairecerif.author.affiliationUniversity of Otago
oairecerif.author.affiliationMahidol University
oairecerif.author.affiliationRoskilde Universitet
oairecerif.author.affiliationDepartment of Bioengineering

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