Association of low density lipoprotein receptor related protein 5 genetic variation, a133v and BMD in thai menopausal women
1
Issued Date
2014
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Anong Kitjaroentham, อนงค์ กิจเจริญธรรม, Hathairad Hananantachai, หทัยรัชต หาญอนันตชัย, Benjaluck Phonrat, Sangchai Preutthipan, Rungsunn Tungtrongchitr, รังสรรค์ ตั้งตรงจิตร (2014). Association of low density lipoprotein receptor related protein 5 genetic variation, a133v and BMD in thai menopausal women. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/63185
Title
Association of low density lipoprotein receptor related protein 5 genetic variation, a133v and BMD in thai menopausal women
Other Contributor(s)
Abstract
Postmenopausal osteoporosis and bone mass are influenced by multiple
factors including genetics. Low density lipoprotein receptor related protein
5 (LRP5), a co-receptor of Wnt signaling, is an important regulator of
bone development and maintenance. The presence of a LRP5 single nucleotide
polymorphism (SNP), A1330V, was determined by PCR-RFLP method in 332 Thai
menopausal women. AA genotype subjects had lower radial BMD (p value = 0.015).
Furthermore, women with low BMI (≤ 25) had higher risk of radial BMD osteoporosis
(Odd’s ratio = 7.41, p value = 0.007) but aging (50 years) and A1330V SNP had no
effect. In conclusion, LRP5 A1330V SNP may contribute to osteoporosis susceptibility
in Thai menopausal women.
Description
Joint International Tropical Medicine Meeting 2014: 3D perspectives on tropical medicine: drivers, diversity and determination the 8th seminar on food-and water-borne parasitic zoonoses: 2-4 December 2014: Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2014. p. 261.