Association of low density lipoprotein receptor related protein 5 genetic variation, a133v and BMD in thai menopausal women

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dc.contributor.authorAnong Kitjaroenthamen_US
dc.contributor.authorอนงค์ กิจเจริญธรรมen_US
dc.contributor.authorHathairad Hananantachaien_US
dc.contributor.authorหทัยรัชต หาญอนันตชัยen_US
dc.contributor.authorBenjaluck Phonraten_US
dc.contributor.authorSangchai Preutthipanen_US
dc.contributor.authorRungsunn Tungtrongchitren_US
dc.contributor.authorรังสรรค์ ตั้งตรงจิตรen_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Department of Tropical Nutrition and Food Scienceen_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Department of Social and Environmental Medicineen_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Department of Clinical Medicineen_US
dc.date.accessioned2015-07-09T04:20:23Z
dc.date.accessioned2021-08-17T06:54:48Z
dc.date.available2015-07-09T04:20:23Z
dc.date.available2021-08-17T06:54:48Z
dc.date.created2015-07-09
dc.date.issued2014
dc.descriptionJoint International Tropical Medicine Meeting 2014: 3D perspectives on tropical medicine: drivers, diversity and determination the 8th seminar on food-and water-borne parasitic zoonoses: 2-4 December 2014: Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2014. p. 261.en
dc.description.abstractPostmenopausal osteoporosis and bone mass are influenced by multiple factors including genetics. Low density lipoprotein receptor related protein 5 (LRP5), a co-receptor of Wnt signaling, is an important regulator of bone development and maintenance. The presence of a LRP5 single nucleotide polymorphism (SNP), A1330V, was determined by PCR-RFLP method in 332 Thai menopausal women. AA genotype subjects had lower radial BMD (p value = 0.015). Furthermore, women with low BMI (≤ 25) had higher risk of radial BMD osteoporosis (Odd’s ratio = 7.41, p value = 0.007) but aging (50 years) and A1330V SNP had no effect. In conclusion, LRP5 A1330V SNP may contribute to osteoporosis susceptibility in Thai menopausal women.en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/63185
dc.language.isoengen_US
dc.rightsMahidol Universityen_US
dc.subjectA1330Ven_US
dc.subjectBMDen_US
dc.subjectLRP5en_US
dc.subjectOsteoporosisen_US
dc.subjectPostmenopausal womenen_US
dc.titleAssociation of low density lipoprotein receptor related protein 5 genetic variation, a133v and BMD in thai menopausal womenen_US
dc.typeProceeding Posteren_US

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