Transfontanelle Thermoacoustic Imaging of Intraventricular Brain Hemorrhages in Live Sheep
Issued Date
2025-01-01
Resource Type
ISSN
02780062
eISSN
1558254X
Scopus ID
2-s2.0-105004225995
Pubmed ID
40315063
Journal Title
IEEE Transactions on Medical Imaging
Volume
44
Issue
8
Start Page
3175
End Page
3184
Rights Holder(s)
SCOPUS
Bibliographic Citation
IEEE Transactions on Medical Imaging Vol.44 No.8 (2025) , 3175-3184
Suggested Citation
Islam M.T., Benavides J., Prakash R., Zafar M., McGuire L.S., Charbel F., Siegel A.P., Erricolo D., Lin J., Gelovani J.G., Avanaki K. Transfontanelle Thermoacoustic Imaging of Intraventricular Brain Hemorrhages in Live Sheep. IEEE Transactions on Medical Imaging Vol.44 No.8 (2025) , 3175-3184. 3184. doi:10.1109/TMI.2025.3566372 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111653
Title
Transfontanelle Thermoacoustic Imaging of Intraventricular Brain Hemorrhages in Live Sheep
Corresponding Author(s)
Other Contributor(s)
Abstract
Preterm neonates are vulnerable to periventricular-intraventricular hemorrhage since the periventricular germinal matrix blood vessels are still immature and fragile until around 36 weeks. While cranial ultrasound imaging (cUS) is the standard technique for diagnosing brain injury in neonates, it has limited accuracy in detecting early-stage hemorrhages due to poor sensitivity and specificity. Transfontanelle thermoacoustic imaging (TTAI) combines the advantages of high contrast from electromagnetic absorption with high-resolution from ultrasound imaging and represents a potential alternative to overcome the limitations of conventional cUS systems. We developed a TTAI system and evaluated its performance in a large animal model of intraventricular hemorrhage (IVH) in vivo. Our system demonstrated the ability to detect hemorrhages as small as 0.1 mL, which is better than the previously reported limit of detection for either ultrasound or photoacoustic imaging in the same animal model. These results indicate that TTAI is a novel imaging modality with high potential for accurate detection of IVH in neonates.