Lima bean (Phaseolus lunatus L.) powder ameliorates pituitary-liver-axis regulation and anti-inflammatory activity in malnourished rats
Issued Date
2024-12-01
Resource Type
eISSN
26618974
Scopus ID
2-s2.0-85211363551
Journal Title
Food Production, Processing and Nutrition
Volume
6
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Food Production, Processing and Nutrition Vol.6 No.1 (2024)
Suggested Citation
Maliza R., Syaidah R., Rosdianto A.M., Tofrizal A., Santoso P., Lesmana R., Arya B., Rafi M. Lima bean (Phaseolus lunatus L.) powder ameliorates pituitary-liver-axis regulation and anti-inflammatory activity in malnourished rats. Food Production, Processing and Nutrition Vol.6 No.1 (2024). doi:10.1186/s43014-024-00269-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102409
Title
Lima bean (Phaseolus lunatus L.) powder ameliorates pituitary-liver-axis regulation and anti-inflammatory activity in malnourished rats
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Abstract
The endocrine system is critical for adapting to malnutrition, which can disrupt the pituitary-liver axis and induce inflammation, leading to health complications. Lima beans (Phaseolus lunatus L.), known for their high protein content and anti-inflammatory properties, present a potential nutritional intervention. This study investigated the effects of lima bean powder on pituitary-liver axis regulation and anti-inflammatory activity in malnourished rats. Rats were divided into four groups: Normal (N), Malnourished (MAL), MAL treated with 25% lima bean flour (MAL + 25% LB), and MAL treated with 50% lima bean flour (MAL + 50% LB) for 6 weeks. Proximate composition was determined to analysed its major nutrients and metabolites in the methanol extract were analysed through LC–MS/MS. Parameters such as weight gain, serum albumin, total protein levels, Growth Hormone (GH), Insulin-like Growth Factor 1 (IGF1), and liver inflammation markers were measured. Bioactive compounds such as L(-)-pipecolinic acid, choline, trigonelline, L-phenylalanine, and oleamide were identified, highlighting the nutritional and therapeutic potential of lima beans. Compared to the N group, the MAL group showed significant decreases in body weight gain, serum albumin, and total protein levels. However, both MAL + 25% LB and MAL + 50% LB groups demonstrated significant improvements in these parameters, approximating the levels observed in the N group. Lima bean supplementation appeared to regulate GH at both the cellular and mRNA levels, positively impacting the pituitary-liver axis. Additionally, the study revealed reduced liver inflammation in the MAL + 25% LB and MAL + 50% LB groups, suggesting the anti-inflammatory properties of lima beans. These findings indicate that lima bean flour supplementation can ameliorate disruptions in the pituitary-liver axis and reduce inflammation in malnourished rats.