Biological Activities of Extracts and Secondary Metabolites from Millettia phuwuaensis
8
Issued Date
2023-02-01
Resource Type
ISSN
26160684
eISSN
26160692
Scopus ID
2-s2.0-85148363639
Journal Title
Tropical Journal of Natural Product Research
Volume
7
Issue
1
Start Page
2207
End Page
2212
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tropical Journal of Natural Product Research Vol.7 No.1 (2023) , 2207-2212
Suggested Citation
Chaikrueang P., Pompimon W., Udomputtimekakul P., Khamto N., Meepowpan P., Natetip P., Khudngaongam N., Wongjaren N., Khuntee D., Michaidi K., Kongbun K., Chueakhamsao S., Issariyajongkol K., Nuntasaen N., Suksen K., Chairoungdua A., Limthongkul J., Naparswad C., Charoenphakinrattana N., Pikulthong S. Biological Activities of Extracts and Secondary Metabolites from Millettia phuwuaensis. Tropical Journal of Natural Product Research Vol.7 No.1 (2023) , 2207-2212. 2212. doi:10.26538/tjnpr/v7i1.17 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81751
Title
Biological Activities of Extracts and Secondary Metabolites from Millettia phuwuaensis
Other Contributor(s)
Abstract
A study of the phytochemicals constituents of the stems of, Millettia phuwuaensis has led to the isolation of 7-methoxy-5/,6/-methylenedioxyisoflavone (1), and 12-deoxo-12α-hydroxyelliptone (2. Their structures were confirmed using NMR spectroscopy. Both extracts and the purified compounds were evaluated for their antibacterial, anti-HIV, and cancer activity. The antibacterial test results of the extracts and pure compound were found to be valuable, MIC is in the range of 12.5-200 mg/mL, in the range of 0.188-6 mg/mL, respectively. Mechanistic anti-HIV affect RT and MC99 found that ethyl acetate extract inhibited the very high level with IC50 with 75.93%. It was also found that all extracts were effective in inhibiting AIDs by mechanism MC99 at EC50 at 1.35 µM (TI>2.41). Further, the ethyl acetate extract showed marked cytotoxicity (ED50 = 17.58 µg/ml against the SH-SY5Y cancer cell line. Additionally, compound 1 also exhibited RT, moderately active with IC50 55.19 % inhibition. More than that, compounds 1 and 2 also exhibited MC99 at 50% (EC50) values of > 3.01 (TI >1.70) and 1.78 (TI >1.70), respectively.