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Publication Metadata only Dissolution improvement of high drug-loaded solid dispersion(2006-06-02) Siriporn Okonogi; Satit Puttipipatkhachorn; Chiang Mai University; Mahidol UniversityThis study focused on an investigation of a high drug-loaded solid dispersion system consisting of drug, carrier, and surfactant. Solid dispersions of a water-insoluble ofloxacin (OFX) with polyethylene glycol (PEG) of different molecular weights..., namely binary solid dispersion systems, were prepared at drug to carrier not less than 5:5. Polysorbate 80, a nonionic surfactant, was incorporated into the binary solid dispersion systems as the third component to obtain the ternary solid dispersionPublication Metadata only Polymer-magnesium aluminum silicate composite dispersions for improved physical stability of acetaminophen suspensions(2009-04-08) Thaned Pongjanyakul; Satit Puttipipatkhachorn; Khon Kaen University; Mahidol UniversityThe aims of this study were to characterize the morphology and size of flocculates and the zeta potential and rheological properties of polymer-magnesium aluminum silicate (MAS) composite dispersions and to investigate the physical properties... of acetaminophen (ACT) suspensions prepared using the composite dispersions as a flocculating/suspending agent. The polymers used were sodium alginate (SA), sodium carboxymethylcellulose (SCMC), and methylcellulose (MC). The results showed that SA, SCMC, and MCPublication Metadata only Nondestructive rheological measurement of aqueous dispersions of solid lipid nanoparticles: Effects of lipid types and concentrations on dispersion consistency(2010-09-01) Nispa Seetapan; Piyawan Bejrapha; Wanwisa Srinuanchai; Satit Puttipipatkhachorn; Uracha Ruktanonchai; Thailand National Metal and Materials Technology Center; Thailand National Science and Technology Development Agency; Mahidol UniversityPurpose: To investigate dispersion consistency of solid lipid nanoparticles as functions of lipid types and concentrations. Methods: Viscoelastic measurement at an application of low stress was employed to characterize the internal microstructure... developed within the dispersions. Pure triglycerides with different length of fatty acid chains, trimyristin (C14), tripalmitin (C16), and tristearin (C18) were studied with respect to the partial triglyceride with C22 chain length (Compritol 888 ATOPublication Metadata only Chitosan-magnesium aluminum silicate composite dispersions: Characterization of rheology, flocculate size and zeta potential(2008-03-03) Wanwisa Khunawattanakul; Satit Puttipipatkhachorn; Thomas Rades; Thaned Pongjanyakul; Khon Kaen University; Mahidol University; University of OtagoComposite dispersions of chitosan (CS), a positively charged polymer, and magnesium aluminum silicate (MAS), a negatively charged clay, were prepared and rheology, flocculate size and zeta potential of the CS-MAS dispersions were investigated. High... and low molecular weights of CS (HCS and LCS, respectively) were used in this study. Moreover, the effects of heat treatment at 60 °C on the characteristics of the CS-MAS dispersions and the zeta potential of MAS upon addition of CS at different pHs werePublication Metadata only Physicochemical properties of ursodeoxycholic acid dispersed in controlled pore glass(1999-08-15) Siriporn Okonogi; Toshio Oguchi; Etsuo Yonemochi; Satit Puttipipatkhachorn; Keiji Yamamoto; Chiang Mai University; Chiba University; Mahidol UniversityThe objective of this study was to reduce the crystallinity of ursodeoxycholic acid (UDCA) by solid dispersion with controlled pore glass (CPG). To evaluate the effect of pore diameter and pore volume of CPG on the crystalline properties of UDCA, we... solid dispersion with CPG obtained by a solvent method. The DSC thermograms of solid dispersions showed that there were two states of UDCA, amorphous and crystalline. The amount of crystalline fraction in the solid dispersions depended on the pore sizePublication Metadata only Enhanced dissolution of ursodeoxycholic acid from the solid dispersion(1997-01-01) Siriporn Okonogi; Etsuo Yonemochi; Toshio Oguchi; Satit Puttipipatkhachorn; Keiji Yamamoto; Chiang Mai University; Chiba University; Mahidol UniversitySolid dispersions of a very slightly water-soluble drug, ursodeoxycholic acid (UDCA), were prepared using urea, mannitol, and PEG 6000 as a carrier, and the solubility of UDCA was determined in water-ethanol (I:I) mixed solvent as a function of UDCA...-carrier ratio. The solubility of UDCA was slightly improved when urea or PEG 6000 was used as a carrier. The powder x-ray diffraction measurements revealed that UDCA did not exist in the crystalline state in the solid dispersions. Differential scanningPublication Metadata only Stabilizing ability of surfactant on physicochemical properties of drug nanoparticles generated from solid dispersions(2017-07-03) Thanu Thongnopkoon; Satit Puttipipatkhachorn; Mahidol University© 2017 Informa UK Limited, trading as Taylor & Francis Group. This study was aimed to examine the nanoparticle formation from redispersion of binary and ternary solid dispersions. Binary systems are composed of various ratios of glibenclamide (GBM...) and polyvinylpyrrolidone K30 (PVP-K30), whereas a constant amount at 2.5%w/w of a surfactant, sodium lauryl sulfate (SLS) or Gelucire44/14 (GLC), was added to create ternary systems. GBM nanoparticles were collected after the systems were dispersed in water for 15 minPublication Metadata only New metastable form of glibenclamide prepared by redispersion from ternary solid dispersions containing polyvinylpyrrolidone-K30 and sodium lauryl sulfate(2016-01-01) Thanu Thongnopkoon; Satit Puttipipatkhachorn; Mahidol University, were obtained from redispersion of ternary solid dispersion systems. The ternary solid dispersion systems, consisting of GBM, polyvinylpyrrolidone- K30 (PVP-K30) and sodium lauryl sulfate (SLS), were prepared by solvent evaporation methodPublication Metadata only Chitosan-magnesium aluminum silicate nanocomposite films: Physicochemical characterization and drug permeability(2010-06-01) Wanwisa Khunawattanakul; Satit Puttipipatkhachorn; Thomas Rades; Thaned Pongjanyakul; Khon Kaen University; Mahidol University; University of OtagoChitosan-magnesium aluminum silicate (CS-MAS) films were prepared and the effects of MAS content and heat treatment of the CS-MAS dispersion before film casting on the physicochemical and drug permeability properties of the films were investigated.... CS could interact with MAS via electrostatic interaction and intermolecular hydrogen bonding mechanisms, resulting in nanocomposite formation, for which it was not necessary to apply the heat treatment on the composite dispersions. The naturePublication Metadata only Investigation of novel alginate-magnesium aluminum silicate microcomposite films for modified-release tablets(2005-10-03) Thaned Pongjanyakul; Aroonsri Priprem; Satit Puttipipatkhachorn; Khon Kaen University; Mahidol UniversityPhysicochemical properties of sodium alginate-magnesium aluminum silicate (SA-MAS) composite films were investigated and a potential as a film former of SA-MAS dispersion for modifying drug release from tablets was evaluated as well. Interaction... coated with SA-MAS dispersion had a smooth surface, while those with SA dispersion showed a pinholing on the surface, resulting in a faster drug release. The drug release profiles of the tablets could be modified by coating with the composite film
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