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Item Metadata only The effect of disruption of circadian rhythm on vascular function in lean (C57BL/6) and obese, leptin resistant (DB/DB) mice(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Nitirut Nernpermpisooth; Suwan Thirawarapan; Stepp, David W.; Wisuda Suvitayavatrisks. However, the mechanisms of circadian disruption on vascular function still remain unclear. The aim of this study is to determine whether disruption of the circadian rhythm impairs the vascular function in lean (C57/BL6) mice (LM) and enhances... the vascular dysfunction in obese, leptin resistant (db/db) mice (Ob). Lean and obese male mice, age 10-11 weeks were subjected to normal 12:12 h light-dark cycle (LD) or constant darkness (DD) to disrupt the circadian rhythm for 4 weeks. The metabolicItem Metadata only The influences of stressors, maternal depression and parenting on conduct problems among preschoolers in Bangkok, Thailand(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Nantiya Ekathikhomkit; Yajai Sitthimongkol; Tassanee Prasopkittikun; Rutja Phuphaibul; Pisamai OrathaiThe purpose of this study was to validate a causal model of relationships among five factors: daily hassles, marital satisfaction, difficult child temperament, maternal depression, and disrupted parenting on Thai preschoolers' conduct problems... satisfaction, difficult child temperament, maternal depression and disrupted parenting accounted for 15% of variance on child conduct problems. These findings supported the significant direct effect of the stressors on child conduct problems through maternalItem Metadata only Effects of alcohol and taurine supplementation on body growth, maternal behaviors, and offspring hippocampal dependent water maze learning(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Pilant Ananchaipatana-Auitragoon; Naiphinich Kotchabhakdi; Nuanchan Jutapakdeegul; Ottersen, Ole Pette; Amiry-Moghaddam, MahmoodIt is well known that maternal alcohol consumption is teratogenic, resulting in damages from structural deformity to mental retardation and disruption of learning and memory. This research investigated effects of alcohol on body growth, learning... that alcohol retarded offspring body growth and disrupted the process of learning and memory. Taurine was not protective to body growth but was shown to protect the learning when available in early stages of the development. It can be concluded that taurineItem Metadata only Development of peptide inhibitors against dengue virus infection by in silico desigh and in vitro studies(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Aussara Panya; Pa-thai Yenchitsomanus; Chatchawan Srisawat; Mutita Junking; Kiattewee Choowongkomonthe hydrophobic pocket on the E protein was the target, and the destabilization of virion structure organization through the disruption of the interaction between the envelope and membrane proteins, respectively. Following the first strategy, molecular docking..., and Huh7 cells at low-micromolar level. The molecular docking technique suggested that MLH40 interacting with envelope proteins can disrupt their regular dimer conformation. The binding of peptide to the target site was a key underlining the inhibitoryItem Metadata only Ultrastructural and immunocytochemical studies of the tegument and cytoskeleton of Opisthorchis viverrini(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Wandee Apinhasmit; Prasert Sobhon; Suchart Upatham; Chaitip Wanichanon. The roles of the cytoskeleton are tested by treating adult parasites with colchicine and cytochalasin B. Following a short incugation period (10-20 min), colchicine disrupts some microtubules which, in ture, affect the transport of dense granules fromItem Metadata only Identification of RNA-processing abnormalities of the PKD1 gene in Thai families with autosomal dominant polycystic kidney disease(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Wanna Thongnoppakhun; Prapon Wilairat; Pa-thai Yenchitsomanus; Mathurose Ponglikitmongkol; Chintana Sirinavinthe deletion did not disrupt the donor or acceptor splice site or branch site in this intron. As the result of exon 43 skipping, the translated polycystin-1 would have in-frame deletion of 97 amino acids in the transmembrane (TM) and loop regions, confirming