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    English Language Teaching In Times Of Crisis: Teacher Agency In Response To The Pandemic-Forced Online Education
    (2021-01-01) Athip Thumvichit; Mahidol University
    Teacher agency occurs when teachers demonstrate a capacity to solve pedagogical and curriculum challenges. This article delves into how tertiary English teachers in Thailand practice their agency in response to the abrupt conversion to online... teaching amid the COVID-19 pandemic. This study drew on teachers’ responses to a questionnaire (n=162) and semi-structure interviews (n=3) to identify their positioning and agentic actions. The results suggest that teachers’ positioning as being
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    Institutional responses to avian influenza in Thailand: Control of outbreaks in poultry and preparedness in the case of human-to-human transmission
    (2008-04-01) Prasert Auewarakul; Wanna Hanchaoworakul; Kumnuan Ungchusak; Mahidol University; Thailand Ministry of Public Health
    Thailand faced an outbreak of H5N1 avian influenza in poultry and in humans in early 2004. By the end of the same year, more than 62 million birds had died or been culled and 17 human cases, with 12 dead, had been detected. Among the human cases..., most people were infected via direct contact with ill or deceased poultry, or when living in households with abnormal poultry deaths. One family cluster with probable human-to-human transmission was identified in September 2004. Recognizing the threat
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    Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles
    (2014-01-01) Udomratana Vattanasit; Panida Navasumrit; Man Bahadur Khadka; Jantamas Kanitwithayanun; Jeerawan Promvijit; Herman Autrup; Mathuros Ruchirawat; Chulabhorn Research Institute; South Carolina Commission on Higher Education; Chulabhorn Graduate Institute; Aarhus Universitet; Mahidol University
    -induced oxidative DNA damage and inflammatory responses in the lung. Human exposure to PM leads to oxidative DNA damage whereas PM-induced inflammation was not conclusive and should be further investigated. © 2013 Elsevier GmbH.... human carcinogen (IARC, 2012), are considered a major contributor to traffic-related particulate matter (PM) in urban areas. DEP consists of various compounds, including PAHs and metals which are the principal components that contribute to the toxicity
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    Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide
    (2013-11-26) Narisara Chantratita; Sarunporn Tandhavanant; Nicolle D. Myers; Sudeshna Seal; Arkhom Arayawichanont; Aroonsri Kliangsa-ad; Lauren E. Hittle; Robert K. Ernst; Mary J. Emond; Mark M. Wurfel; Nicholas P.J. Day; Sharon J. Peacock; T. Eoin West; Mahidol University; University of Washington, Seattle; Sappasitthiprasong Hospital; University of Maryland, Baltimore; Nuffield Department of Clinical Medicine; University of Cambridge
    responses to invading bacteria are precipitated by activation of host pathogen recognition receptors by pathogen associated molecular patterns. Human melioidosis is characterized by up-regulation of pathogen recognition receptors and pro-inflammatory... cytokine release. In contrast to many gram-negative pathogens, however, the lipopolysaccharide of B. pseudomallei is considered only weakly inflammatory. We conducted a study in 300 healthy Thai subjects to investigate the ex vivo human blood response
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    Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis
    (2011-04-01) Duangchan Suwannasaen; Jirawan Mahawantung; Wipada Chaowagul; Direk Limmathurotsakul; Philip L. Felgner; Huw Davies; Gregory J. Bancroft; Richard W. Titball; Ganjana Lertmemongkolchai; Khon Kaen University; Sappasitthiprasong Hospital; Mahidol University; University of California, Irvine; University of Exeter
    Background. We aimed to determine the antibody and T cell responses to Burkholderia pseudomallei of humans to select candidate vaccine antigens. Methods. For antibody profiling, a protein microarray of 154 B. pseudomallei proteins was probed... with plasma from 108 healthy individuals and 72 recovered patients. Blood from 20 of the healthy and 30 of the recovered individuals was also obtained for T cell assays. Results. Twenty-seven proteins distinctively reacted with human plasma following
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    Molecular pathways executing the "trophic sentinel" response in HPV-16 E7-expressing normal human diploid fibroblasts upon growth factor deprivation
    (2004-02-05) Alexandra Eichten; Debrah S. Rud; Miranda Grace; Siribang On Piboonniyom; Valerie Zacny; Karl Münger; Harvard Medical School; University of California, San Francisco; Mahidol University
    In response to oncogenic insults, normal human cells execute a defense response that culminates in cellular suicide, apoptosis. Normal human diploid fibroblasts expressing the human papillomavirus type 16 (HPV-16) E7 oncoprotein are predisposed... to apoptosis when they are deprived of growth factors. Even though a dominant negative p53 mutant abrogates the cell death response, it is not accompanied by p53 phosphorylation, the DNA binding capacity of p53 remains unaltered, and no activation of common p53
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    Immune response in human chromoblastomycosis and eumycetoma – focusing on human interleukin-17A, interferon-gamma, tumour necrosis factor-alpha, interleukin-1 beta and human beta-defensin-2
    (2016-12-01) Charussri Leeyaphan; Carren Hau; Shintaro Takeoka; Yayoi Tada; Sumanas Bunyaratavej; Penvadee Pattanaprichakul; Panitta Sitthinamsuwan; Angkana Chaiprasert; Yuko Sasajima; Koichi Makimura; Shinichi Watanabe; Teikyo University; Mahidol University
    © 2016 Blackwell Verlag GmbH Knowledge regarding host immune response to chromoblastomycosis and eumycetoma is limited, particularly concerning cytokines and antimicrobial peptides production. This was a retrospective study of 12 paraffin-embedded... tissue samples from patients diagnosed with chromoblastomycosis or eumycetoma from histological findings and tissue culture. DNA extraction and polymerase chain reaction (PCR) from tissues were done to evaluate human interleukin-17A (IL-17A), interferon
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    Female sex hormones modulate Porphyromonas gingivalis lipopolysaccharide-induced Toll-like receptor signaling in primary human monocytes
    (2016-06-01) P. Jitprasertwong; N. Charadram; S. Kumphune; S. Pongcharoen; S. Sirisinha; Naresuan University; Mahidol University
    inflammation. Therefore, we aimed to investigate the role of β-estradiol and progesterone in human monocyte immune responses, at cellular and molecular levels, to identify their role as a possible immunological link between pregnancy and periodontal disease... the phosphorylation of the p38, the extracellular signal-regulated kinase 1/2 and the c-Jun N-terminal activated kinase in P. gingivalis LPS-stimulated monocytes. Thus, the inhibitory effects of these hormones on the response of human monocytes to P. gingivalis LPS
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    Role of Toll-like receptor 2 in mediating the production of cytokines and human beta-defensins in oral mucosal epithelial cell response to Leptospiral infection
    (2019-12-01) Naharuthai Inthasin; Patimaporn Wongprompitak; Chawikan Boonwong; Pattama Ekpo; Faculty of Medicine, Siriraj Hospital, Mahidol University
    peptides (AMPs) in response to microbial infection. Human β-defensins (hBDs); hBD1, hBD2, and hBD3 are predominantly AMPs expressed in the oral cavity. Toll-like receptors (TLRs) have been reported in hBD regulation. TLR2 recognizes leptospiral... epithelial cells and tissue were similar in terms of TLR expression. All primary epithelial cells expressed TLR2 and hBD1-3. We used primary epithelial cells to study response to L. interrogans. Our results yielded the first evidence that human TLR2 regulates
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    Antibody responses in human gnathostomiasis.
    (1988-06-01) C. Nopparatana; P. Tapchaisri; P. Setasubun; W. Chaicumpa; P. Dekumyoy; Mahidol University
    Sera from 4 patients with parasitologically confirmed gnathostomiasis and from 18 healthy individuals were studied by SDS-PAGE and Western blot analysis using radioiodinated protein A to detect antibody responses against crude aqueous somatic... extract of advanced third stage larvae of Gnathostoma spinigerum (L3G). It was found that the L3G extract was highly complex, comprising of more than 40 polypeptides among which more than 20 components were antigenic in human. The relative M