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Publication Open Access Factors associated with anaemia among pregnant women in Kegalle district, Sri Lanka(2015) Sriyal Wijesinghe; Sariyamon Tiraphat; Seo Ah Hong; Jiraporn Chompikul; Nilmini Hemachandra; Mahidol University. ASEAN Institute for Health DevelopmentMaternal nutritional status is an important factor for a better outcome of the pregnancy. Anaemia and being underweight are preventable nutritional deficiencies which should be addressed long before the pregnancy. This cross sectional analytical..., birth spacing with a child less than 3 yrs of age and strengthening of pre-pregnancy iron supplementation for expecting women with low BMI (underweight) will be useful modes to prevent future anaemia during the pregnancy.Publication Open Access ผลของโปรแกรมส่งเสริมโภชนาการและการรับประทานยาบำรุงธาตุเหล็กต่อภาวะโลหิตจางจากการขาดธาตุเหล็กในสตรีตั้งครรภ์(2558) วิภาวดี พิพัฒน์กุล; Wipawadee Pipatkul; นิตยา สินสุกใส; Nittaya Sinsuksai; วรรณา พาหุวัฒนกร; Wanna Phahuwatanakorn; มหาวิทยาลัยมหิดล. คณะพยาบาลศาสตร์; อุบลราชธานี. ศูนย์อนามัยที่ 7. กลุ่มอนามัยแม่และเด็กPurpose: To determine effects of a nutrition and iron supplement promoting program on iron deficiency anemia in pregnant women visiting the antenatal care unit at Sunpasitthiprasong Hospital, Ubonratchathani Province. Design: Quasi-experimental... the experimental group received the nutrition and iron supplement promoting program. Hematocrit was measured eight weeks after recruitment. Data were analyzed by frequency, percentage, mean, standard deviation, Chi-Square test, and t-test. Main findingPublication Open Access Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children.(2014) Siwaporn Pinkaew; Rita Wegmuller; Emorn Wasantwisut; Pattanee Winichagoon; Hurrell, Richard F.; Tanumihardjo, Sherry A.; Mahidol University. Institute of NutritionVitamin A (VA)-fortified rice is a potential intervention strategy to prevent VA deficiency in at-risk populations. Hot-extruded, triple-fortified rice grains with added VA, zinc, and iron were produced by hot extrusion technology and their ability... to improve VA status was tested in Thai schoolchildren. The fortification levels were 10 mg of iron, 9 mg of zinc, and 1.05 mg of VA/g extruded rice. A paired stable isotope dilution technique with labeled 13C2-retinyl acetate (13C-RID) was used to quantifyPublication Open Access Relationship between stunting and food provided to children aged from 6 to 24 months in Soc Son district, Hanoi,Vietnam(2009) Vu, Thi Nguyet Anh; Jiraporn Chompikul; จิราพร ชมพิกุล; Sirikul Isaranurug; ศิริกุล อิศรานุรักษ์; Jiraporn Chompikul; Mahidol University. ASEAN Institute for Health Developmentlow birth weight (OR=7.720, 95% CI = 1.672-35.687), inappropriate feeding practices (OR=1.929, 95% CI=1.124-3.308) and having ARI (OR=4.315, 95% CI=1.361-13.677). Appropriate nutritional education, diet and iron supplementation should be given... selected as a study group and 118 normal children were selected as a control group. Secondary data included nutritional status and child’s birth weight. Mothers were interviewed and measured for their height after giving consent to participate. From ChiPublication Open Access Glutathione Redox system in Beta-Thalassemia/Hb E patients(2013) Kalpravidh, Ruchaneekorn W.; Thongchai Tangjaidee; Suneerat Hatairaktham; Ratiya Charoensakdi; Narumol Panichkul; Noppadol Siritanaratkul; Suthat Fucharoen; Mahidol University. Institute of Molecular Biosciences. Thalassemia Research Center; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Medicine; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Biochemistryβ-thalassemia/Hb E is known to cause oxidative stress induced by iron overload. The glutathione system is the major endogenous antioxidant that protects animal cells from oxidative damage. This study aimed to determine the effect of disease state... were recruited and blood was collected. The GSH/GSSG ratio, activities of glutathione-related enzymes, hematological parameters, and serum ferritin levels were determined in individuals. Patients had high iron-induced oxidative stress, shownPublication Open Access Nutritional status and related factors among elementary school students in Banda Aceh Municipality,Nanggroe Aceh Darussalam province, Indonesia(2008) Badrialaily; บาเดียไลลี; Jutatip Silabutra; Pantyp Ramosoota; Mahidol University. ASEAN Institute for Health DevelopmentA descriptive cross sectional study was conduct to study nutritional status and related factors among elementary school children Banda Aceh Municipality, NAD Province, Indonesia. Basic statistics and Chi-square were used to analyze the data. 80....99% of respondent live with parents, and two third of them had healthy weight. All of them took snack at least 1 time per day, and they mostly spent between 1,743- 3,785 rupiah daily for buying snack. The association between nutritional status and somePublication Open Access Identification and key management of non-transfusion-dependent thalassaemia patients: not a rare but potentially under-recognised condition(2014) Vip Viprakasit; Tyan, Paul; Sarayuth Rodmai; Taher, Ali T.; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pediatrics and Thalassemia Centerspleen and/or liver, skeletal deformities, growth retardation, elevated serum ferritin and iron overload. The contributing factors to disease progression are ineffective erythropoiesis and increased haemolysis, which lead to chronic anaemia. The body’s... from other anaemias including sideroblastic anaemia, paroxysmal nocturnal haemoglobinuria, congenital dyserythropoietic anaemia, myelodysplastic syndromes and iron-deficiency anaemia. Management of NTDT is based on managing symptoms, and includesItem Open Access รายงานประจำปี 2559 สถาบันโภชนาการ มหาวิทยาลัยมหิดล(2560) มหาวิทยาลัยมหิดล. สถาบันโภชนาการPublication Open Access Consumption of Palm Date Herbal Beverage: Effect on Maternal and Infant Nutritional Status(2021) Chanadda Tanasinpiboon; Patcharanee Pavadhgul; Akkarach Bumrungpert; Mahidol University. Faculty of Public Health. Department of Nutrition; Dhurakij Pundit University. College of Integrative Medicine. Anti-Aging and Regenerative MedicineThis research aimed to examine the effect of a palm date beverage containing herbal beads on maternal and infant nutritional status. A randomized placebo-controlled trial was conducted in exclusively breastfed infants (aged one to six months... flower, lemon basil, and Thai basil (65 ml/bottle), two bottles/day, for four weeks and the other group consumed a placebo drink. Maternal and infant nutritional status was measured before and after the intervention using a body composition analyzerPublication Open Access Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions(2014) Siroj Jitprasutwit; Ong, Catherine; Niramol Juntawieng; Wen Fong Ooi; Hemsley, Claudia M.; Paiboon Vattanaviboon; Titball, Richard W.; Tan, Patrick; Sunee Korbsrisate; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of ImmunologyBackground: Burkholderia pseudomallei, the causative agent of melioidosis, is a Gram-negative bacterium widely distributed in soil and water in endemic areas. This soil saprophyte can survive harsh environmental conditions, even in soils where herbicides (containing superoxide generators) are abundant. Sigma factor E (σE) is a key regulator of extra-cytoplasmic stress response in Gram-negative bacteria. In this study, we identified the B. pseudomallei σE regulon and characterized the indirect role that σE plays in the regulation of spermidine, contributing to the successful survival of B. pseudomallei in stressful environments. Results: Changes in the global transcriptional profiles of B. pseudomallei wild type and σE mutant under physiological and oxidative stress (hydrogen peroxide) conditions were determined. We identified 307 up-regulated genes under oxidative stress condition. Comparison of the transcriptional profiles of B. pseudomallei wild type and σE mutant under control or oxidative stress conditions identified 85 oxidative-responsive genes regulated by σE, including genes involved in cell membrane repair, maintenance of protein folding and oxidative stress response and potential virulence factors such as a type VI secretion system (T6SS). Importantly, we identified that the speG gene, encoding spermidine-acetyltransferase, is a novel member of the B. pseudomallei σE regulon. The expression of speG was regulated by σE, implying that σE plays an indirect role in the regulation of physiological level of spermidine to protect the bacteria during oxidative stress. Conclusion: This study identified B. pseudomallei genes directly regulated by σE in response to oxidative stress and revealed the indirect role of σE in the regulation of the polyamine spermidine (via regulation of speG) for bacterial cell protection during oxidative stress. This study provides new insights into the regulatory mechanisms by which σE contributes to the survival of B. pseudomallei under stressful conditions.
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