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Item Metadata only Updated reference values for BMD and lean mass measured by DXA in Thai children(2024-01-01) Prajantawanich K.; Manpayak T.; Pooliam J.; Nakavachara P.; Prajantawanich K.; Mahidol Universityupon 2014 normative data for Thai children, which included L2–L4 BMD, total body BMD (head included), and total LM. Materials and methods: We reanalyzed total body and lumbar spine DXA scans (Lunar Prodigy Pro, GE Healthcare; enCORE version 7.53) from... 174 boys and 193 girls, using upgraded software (enCORE version 17SP2) for TBLH BMD, L1–L4 BMD, and LM analysis. The “enhanced” mode was applied for TBLH BMD and LM. Adjustments for total and appendicular LM were made relative to squared height (m2Publication Metadata only Comparative genomics of Edwardsiella ictaluri revealed four distinct host-specific genotypes and thirteen potential vaccine candidates(2021-07-01) Vimbai Irene Machimbirike; Pichahpuk Uthaipaisanwong; Pongsak Khunrae; Ha Thanh Dong; Saengchan Senapin; Triwit Rattanarojpong; Sawannee Sutheeworapong; Suan Sunandha Rajabhat University; Mahidol University; Thailand National Center for Genetic Engineering and Biotechnology; King Mongkut's University of Technology Thonburi. Phylogenetic analysis using core genome MLST (cgMLST) and ANI values consistently placed E. ictaluri isolates into 4 host-specific genotypes. Presence of unique genes and absence of certain genes from each genotype provided potential biomarkers for further... genomes of E. ictaluri originated from diseased hybrid red tilapia (Oreochromis sp.) and striped catfish (Pangasianodon hypophthalmus) in Southeast Asia. E. ictaluri species has an open pan-genome consisting of 2615 core genes and 5592 pan genesPublication Metadata only Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B(2019-10-01) Natthaya Chuaypen; Sunchai Payungporn; Kittiyod Poovorawan; Watcharasak Chotiyaputta; Teerha Piratvisuth; Pisit Tangkijvanich; Chulalongkorn University; Mahidol University; Faculty of Medicine, Siriraj Hospital, Mahidol University; Prince of Songkla Universitythe role of baseline sequence variations in the enhancer II (EnhII), basal core promotor (BCP) and pre-core (PC) regions of HBV genotype C in patients treated with pegylated interferon (PEG-IFN). Patients with HBeAg-positive chronic hepatitis B (CHB... mutations and their combination yielded negative predictive values of 94.7%, 85.7% and 93.8%, respectively. The presence of HBV mutants in the BCP region determined by NGS at baseline was associated with poor treatment outcome in patients with HBeAg-positivePublication Metadata only Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib(2018-07-18) Pongpol Thanuphol; Yukihiro Asami; Kazuro Shiomi; Ariyaphong Wongnoppavich; Patoomratana Tuchinda; Noppamas Soonthornchareonnon; Mahidol University; Kitasato University; Chiang Mai Universityguided isolation was done by means of solvent partition, chromatography and precipitation to provide four isolated compounds: a novel compound 1 with the core structure of 1-azaanthraquinone moiety referred as marcanine G; as well as compounds 2–4.... Marcanine G (1) was considered the most active compound indicating the IC 50 values of 14.87 and 15.18M against human lung cancer cells (A549) and human breast cancer cells (MCF7), respectively. However, 2 showed mild activity with the IC 50 values of 83Item Metadata only Lipid-Polymer Hybrid Nanoparticles Synthesized via Lipid-Based Surface Engineering for a robust drug delivery platform(2024-05-01) Soomherun N.; Kreua-ongarjnukool N.; Niyomthai S.T.; Chumnanvej S.; Soomherun N.; Mahidol UniversityHerein, lipid-polymer core-shell hybrid nanoparticles composed of poly(D,L-lactic-co-glycolic acid) (PLGA)/lecithin (PLNs) were synthesized through lipid-based surface engineering. Lipids were absorbed onto the surface of the PLGA core to enhance..., the data best fit the Korsmeyer-Peppas model with R2 values of 0.989, 0.990, and 0.982 for 1.0, 3.0, and 5.0 mg/mL lecithin, respectively. The release exponents obtained ranged from 0.480 to 0.505, suggesting anomalous transport release. Thus, NCH-PLNs havePublication Metadata only Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force(2010-08-02) Nittaya Tresilwised; Pimolpan Pithayanukul; Olga Mykhaylyk; Per Sonne Holm; Regina Holzmüller; Martina Anton; Stefan Thalhammer; Denis Adigüzel; Markus Döblinger; Christian Plank; Technical University of Munich; Mahidol University; Helmholtz Center Munich German Research Center for Environmental Health; Ludwig-Maximilians-Universitat Muncheninfection in multidrug-resistant (MDR) cancer cells in vitro and upon intratumoral injection in vivo. The virus was complexed by self-assembly with core-'shell nanoparticles having a magnetite core of about 10 nm and stabilized by a shell containing 68 mass.... Increased virus internalization resulted in a 10-fold enhancement of the oncolytic potency in terms of the dose required for killing 50% of the target cells (IC50value) and an enhancement of 4 orders of magnitude in virus progeny formation at equal inputPublication Metadata only Modeling of bone formation and resorption mediated by parathyroid hormone: Response to estrogen/PTH therapy(2003-01-01) Chontita Rattanakul; Yongwimon Lenbury; Nateetip Krishnamara; David J. Wollkind; Mahidol University; Washington State Universityof the system's parametric values. Effects of estrogen and PTH administrations are then investigated by extending on the core model. Analysis of the model seems to indicate that the paradoxical observation that intermittent PTH administration causes net bonePublication Metadata only Unified synthesis and cytotoxic activity of 8-O -methylfusarubin and its analogues(2019-01-01) Pongsit Vijitphan; Vatcharin Rukachaisirikul; Chatchai Muanprasat; Panata Iawsipo; Jiraporn Panprasert; Kwanruthai Tadpetch; Mahidol University; Burapha University; Prince of Songkla Universitycore was performed to construct the two analogues, fusarubin and anhydrofusarubin. This work also highlights an unprecedented directing effect of the hydroxymethylene group in the selective hypervalent iodine-mediated quinone oxidation. The four... synthetic compounds were evaluated for their in vitro cytotoxic activities against six human cancer cells. 8-O-Methylfusarubin was the most potent analogue and displayed excellent cytotoxic activity against MCF-7 breast cancer cells with an IC50 value of 1Publication Metadata only Metal complexes of uracil derivatives with cytotoxicity and superoxide scavenging activity(2012-03-01) Supaluk Prachayasittikul; Apilak Worachartcheewan; Ratchanok Pingaew; Thummaruk Suksrichavalit; Chartchalerm Isarankura-Na-Ayudhya; Somsak Ruchirawat; Virapong Prachayasittikul; Srinakharinwirot University; Mahidol University; Chulabhorn Research Institute5-Substituted uracils were reported to be important core structure of diverse therapeutics. Herein, novel mixed ligand transition metal (Mn, Cu, Ni) complexes of 5-iodouracil (5Iu) with 8-hydroxyquinoline or 8HQ (1-3) and 5-nitrouracil (5Nu) with 8...HQ (4-6) have been synthesized. The metal complexes 1-6 exert significant cytotoxicity against HepG2, A-549, HuCCA-1 and MOLT-3 cell lines. Particularly, the cytotoxicities of tested complexes against HepG2 cells show their IC 50 values lower thanPublication Metadata only Performance evaluation of flow field-flow fractionation and electrothermal atomic absorption spectrometry for size characterization of gold nanoparticles(2019-10-25) Sutthinee Mekprayoon; Atitaya Siripinyanond; Mahidol Universityno significant difference using paired t-test with the critical value of t as 4.30 (P = 0.05). The experimental results indicated that the size of AuNPs from two methods, Fl-FFF with DLS for hydrodynamic diameter and ETAAS with TEM for core size, were
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