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Publication Metadata only Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration(1983-01-01) Nongporn Hutadilok; Witaya Thamavit; E. Suchart Upatham; Pintip Ruenwongsa; Mahidol University, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg-1body weight, and approached normal levels two weeks after treatment. In the infected hamsters, praziquantel, at a curative dose, caused aPublication Metadata only Modulation of dihydroxy-di-n-propylnitrosamine-induced liver lesion development in Opisthorchis-infected Syrian hamsters by praziquantel treatment in association with butylated hydroxyanisole or dehydroepiandrosterone administration(1998-01-01) Malcolm A. Moore; Witaya Thamavit; Danai Tiwawech; Nobuyuki Ito; Hiroyuki Tsuda; National Cancer Center Research Institute; Mahidol University; National Cancer Institute Thailand; Nagoya City UniversityThe effects of praziquantel coupled with dehydroepiandrosterone (DHEA) or butylated hydroxyanisole (BHA) administration 16 weeks subsequent to dihydroxy-di-n-propylnitrosamine (DHPN) treatment and infection with Opisthorchis viverrini (OV) on lesion... development in the liver of Syrian hamsters were investigated. Animals were given 80 OV metacercariae and then two i.p. injections of DHPN (500 mg/kg body weight) 4 and 5 weeks thereafter. At week 16, groups received praziquantel (250 mg/kg, i.g.) and werePublication Metadata only Time‐dependent Modulation of Liver Lesion Development in Opisthorchis‐infected Syrian Hamster by an Antihelminthic Drug, Praziquantel(1993-01-01) Witaya Thamavit; Malcolm A. Moore; Stitaya Sirisinha; Tomoyuki Shirai; Nobuyuki Ito; Mahidol University; Nagoya City University Medical Schoolunclear. The effects of administration of praziquantel, an antihelminthic drug, at different time points subsequent to infection with Opisthorchis viverrini (OV) on 2,2′‐dihydroxy‐di‐n‐propylnitrosamine (DHPN)‐initiated lesion development in the liver...). Survivors at week 38 were killed and examined. It was found that whereas praziquantel administration at the earlier two time points was effective at reducing hepatocellular nodule development, the results for cholangiocellular lesions were less pronouncedPublication Metadata only Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver(1992-01-31) W. Thamavit; M. A. Moore; Somsak Ruchirawat; N. Ito; Mahidol University; Nagoya City University Medical SchoolThe effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11... with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver. © 1992.Publication Metadata only Repeated exposure to opisthorchis viverrini and treatment with the antihelminthic praziquantel lacks carcinogenic potential(1992-02-01) Witaya Thamavit; Malcolm A. Moore; Somsak Ruchirawat; Nobuyuki Ito; Mahidol University; Nagoya City University Medical SchoolThe effects of repeated Praziquantel administration, subsequent to infection and reinfection w Opisthorchis viverrini (OV), on lesion development in the Syrian hamster liver were investigated. Five applications of the antihelminthic drag were made... development of either hepatocellular of cholangiocellular preneoplastic/neoplastic lesions. The results indicate that repeated exposure to Praziquantel at levels sufficient for successful removal of parasite infestation does not itself carry carcinogenic riskPublication Metadata only Experimental investigation of opisthorchiasis-associated cholangiocarcinoma induction in the syrian hamster - pointers for control of the human disease(2003-01-01) Suchart Chaimuangraj; Witaya Thamavit; Hiroyuki Tsuda; Malcolm A. Moore; Mahidol University; National Cancer Center Research Instituteinsult. While removal of the parasite with the antihelminthic drug Praziquantel can protect against carcinogenesis, this is dependent on the timing of the drug administration and the efficacy of application to the human situation remains to be confirmed