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Now showing 1 - 10 of 14
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    Exposure of Young Children to Permethrin and Cypermethrin Insecticides in the Residential Environment
    (2024-07-01) Sirikanyaporn S.; Nankongnab N.; Kongtip P.; Siri S.; Suk W.A.; Woskie S.R.; Sirikanyaporn S.; Mahidol University
    , household characteristics, insecticide usage and exposure-related behavior in children was used to interview parents or family caregivers. Permethrin and cypermethrin concentrations on floor surfaces and children’s hands, as well as their urinary metabolites... metabolites were 0.84, 0.31 and 1.23 nmol/g creatinine, respectively. This study found that household insecticide product usage and having a tile floor were associated with increased permethrin concentrations on the children’s hands and floor surfaces. However
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    Insecticidal Effects of Triterpene Glycosides Extracted from Holothuria atra (Echinodermata: Holothuroidea) Against Spodoptera litura (Lepidoptera: Noctuidae)
    (2019-08-03) Saksit Nobsathian; Torranis Ruttanaphan; Vasakorn Bullangpoti; Kasetsart University; Mahidol University
    and studied to control this pest species; however, few natural products from marine organisms have been studied for their pesticidal efficiency. This study compared the acute contact toxicity of solvent extracted from the viscera of Holothuria atra... and isolated triterpene glycoside compounds on third-instar S. litura. Our results showed that crude methanolic extracts were the most toxic to the larvae (LC50 ~ 10.37 mg/ml) compared with other crude extracts and contained the bioactive compound 3
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    Longitudinal study of thyroid hormones between conventional and organic farmers in Thailand
    (2020-12-01) Noppanun Nankongnab; Pornpimol Kongtip; Nichcha Kallayanatham; Ritthirong Pundee; Jutharak Yimsabai; Susan Woskie; University of Massachusetts Lowell; Mahidol University; Buddhachinaraj Phitsanulok Hospital; EHT
    while controlling gender, baseline age, and body mass index (BMI) was used to compare between conventional and organic farmers or the impact of cumulative days of spraying insecticides, herbicides or fungicides. The estimated marginal means... of the thyroid hormone levels (TSH, FT3, T3, and T4) estimated from the linear mixed models were significantly higher among the conventional farmers than organic farmers. As cumulative spray days of insecticide, herbicide or fungicide increased, TSH and FT3
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    Mitochondrial dysfunction from malathion and chlorpyrifos exposure is associated with degeneration of GABAergic neurons in Caenorhabditis elegans
    (2022-11-01) Thosapornvichai T.; Huangteerakul C.; Jensen A.N.; Jensen L.T.; Mahidol University
    Toxicity resulting from off-target effects, beyond acetylcholine esterase inhibition, for the commonly used organophosphate (OP) insecticides chlorpyrifos (CPS) and malathion (MA) was investigated using Saccharomyces cerevisiae and Caenorhabditis... analysis suggests that stress from CPS and MA results in mitochondrial dysfunction, with GABAergic neurons sensitized to these effects. These findings may aid in the understanding of toxicity from CPS and MA from high concentration exposure leading
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    Bacillus thuringiensis cry4ba insecticidal toxinexploits leu615 in its c‐terminal domain to interact with a target receptor—aedes aegypti membrane‐bound alkaline phosphatase
    (2021-08-01) Anon Thammasittirong; Sutticha Na Ranong Thammasittirong; Chompounoot Imtong; Sathapat Charoenjotivadhanakul; Somsri Sakdee; Hui Chun Li; Siriporn Okonogi; Chanan Angsuthanasombat; Kasetsart University, Kamphaeng Saen Campus; Tzu Chi University; Institute of Molecular Biosciences, Mahidol University; Prince of Songkla University; Chiang Mai University; Biophysics Institute for Research and Development (BIRD)
    In addition to the receptor‐binding domain (DII), the C‐terminal domain (DIII) of threedomain Cry insecticidal δ‐endotoxins from Bacillus thuringiensis has been implicated in target insect specificity, yet its precise mechanistic role remains... toxicity.
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    Phytoextraction Potential of Sunn Hemp, Sunflower, and Marigold for Carbaryl Contamination: Hydroponic Experiment
    (2022-12-01) Sooksawat N.; Inthorn D.; Chittawanij A.; Vangnai A.; Kongtip P.; Woskie S.; Mahidol University
    The phytoextraction ability and responses of sunn hemp, sunflower, and marigold plants were investigated toward carbaryl insecticide at 10 mg L−1 and its degradative product (1-naphthol). All test plants exhibited significant carbaryl removal... toxicity symptoms caused by carbaryl and the highest bioconcentration factor (1848), indicating its hyperaccumulating capability. Sunflower responded to carbaryl exposure differently, with the highest carbaryl accumulation (8.7 mg kg−1) in roots within 4
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    Large crystal toxin formation in chromosomally engineered Bacillus thuringiensis subsp. aizawai Due to σ E accumulation
    (2012-03-01) Wasin Buasri; Watanalai Panbangred; Mahidol University; Center of Excellence for Agricultural Biotechnology (AG-BIO/PERDO-CHE)
    K . These results on large-crystal toxin formation with enhanced toxicity should provide useful information for the generation of strains with improved insecticidal activity. © 2012, American Society for Microbiology....Seven distinct Bacillus thuringiensis subsp. aizawai integrants were constructed that carried the chitinase (chiBlA) gene from B. licheniformis under the control of the cry11Aa promoter and terminator with and without p19 and p20 genes. The toxicity
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    Cytotoxic effects and intracellular localization of bin toxin from lysinibacillus sphaericus in human liver cancer cell line
    (2021-01-01) Simab Kanwal; Shalini Abeysinghe; Monrudee Srisaisup; Panadda Boonserm; Institute of Molecular Biosciences, Mahidol University
    Binary toxin (Bin toxin), BinA and BinB, produced by Lysinibacillus sphaericus has been used as a mosquito-control agent due to its high toxicity against the mosquito larvae. The crystal structures of Bin toxin and non-insecticidal but cytotoxic... by confocal laser scanning microscope. HepG2 cells treated with BinA and BinB (50 µg/mL) showed modified cell morphological features and reduced cell viability. Bin toxin showed no toxicity against Hs68 cells. The EC50 values against HepG2 at 24 h were 24 ng/m
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    Urinary organophosphate metabolites and metabolic biomarkers of conventional and organic farmers in Thailand
    (2021-12-01) Pornpimol Kongtip; Noppanun Nankongnab; Nichcha Kallayanatham; Jutamanee Chungcharoen; Chanapa Bumrungchai; Sumate Pengpumkiat; Susan Woskie; University of Massachusetts Lowell; Mahidol University; EHT
    ), and low-density lipoproteins (LDL) were measured. The average age, gender, education, and self-reported agricultural work time, work in second jobs, smoking status, alcohol consumption, insecticide use at home, home location near farmlands and years
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    Emamectin Poisoning in Thailand: Clinical Characteristics and Outcomes
    (2024-09-01) Trakulsrichai S.; Sittiyuno P.; Tansuwannarat P.; Tongpoo A.; Trakulsrichai S.; Mahidol University
    Emamectin benzoate (Emamectin) is a broad-spectrum insecticide. Current data regarding emamectin poisoning in humans are very limited. We performed a 10-year retrospective cross-sectional study (2011–2020) using data from the Ramathibodi Poison