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Publication Metadata only Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand(2000-09-01) Pongrama Ramasoota; Waranya Wongwit; Prasert Sampunachot; Komes Unnarat; Maeya Ngamying; Stefan B. Svenson; Mahidol University; Prapradaeng Hospital; Leprosy Division; Swedish University of Agricultural Sciences Faculty of Veterinary Medicine and Animal Science; Sveriges lantbruksuniversitetA new finding is reported of multiple mutations in the rpoB gene of 9 Mycobacterium leprae strains from leprosy patients in Thailand, who did not respond to therapy even when rifampicin, the main drug in multi-drug therapy was used. By means... of sequence analysis of 9 Thai M. leprae strains, various mutations in 289 bps of the rpoB gene revealed forms of mutation never before described, such as multiple mutations (ie, mutation at two, three, six, seven, eight and nine positions in the rpoB geneItem Metadata only Sergentomyia khawi: a potential vector for Leishmania and Trypanosoma parasites affecting humans and animals and insecticide resistance status in endemic areas of Songkhla, southern Thailand(2024-12-01) Phumee A.; Sutthanont N.; Chitcharoen S.; Sawaswong V.; Boonserm R.; Ayuyoe P.; Cantos-Barreda A.; Siriyasatien P.; Phumee A.; Mahidol Universitysand flies were then identified to species level using molecular techniques. Subsequent analyses included the detection of pathogens and the identification of pyrethroid resistance mutations within the voltage-sensitive sodium channel (Vgsc) domain IIS6..., or F1020S mutations were detected in Vgsc gene. Conclusions: The results of this study provide valuable information on sand fly species and the continuous circulation of Leishmania spp. and Trypanosoma spp. in Songkhla, southern Thailand. MoreoverPublication Metadata only Comparative Genomic Analysis and a Novel Set of Missense Mutation of the Leptospira weilii Serogroup Mini From the Urine of Asymptomatic Dogs in Thailand(2021-10-18) Alongkorn Kurilung; Vincent Perreten; Nuvee Prapasarakul; Siriraj Hospital; Chulalongkorn University; University of BernLeptospira weilii belongs to the pathogenic Leptospira group and is a causal agent of human and animal leptospirosis in many world regions. L. weilii can produce varied clinical presentations from asymptomatic through acute to chronic infections... into the missense mutations, focusing on the known pathogenesis-related genes. Whole genome sequences revealed that the CUDO6 and CUD13 strains each contained two chromosomes and one plasmid, with average genome size and G+C content of 4.37 Mbp and 40Publication Metadata only Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity(2021-05-01) Anie Day D.C. Asa; Rujira Wanotayan; Mukesh Kumar Sharma; Kaima Tsukada; Mikio Shimada; Yoshihisa Matsumoto; Tokyo Institute of Technology; Mahidol University; S.P.C. Govt. Collegeto be associated with immunodeficiency in human as well as in model animals. Several human patients with mutations in XRCC4 were reported to exhibit microcephaly and growth defects, but unexpectedly showed normal immune function. Here, to evaluate the functionality...Non-homologous end joining is one of the main pathways for DNA double-strand break (DSB) repair and is also implicated in V(D)J recombination in immune system. Therefore, mutations in non-homologous end-joining (NHEJ) proteins were foundPublication Metadata only Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis(2012-07-01) Lorena Diaz; Pattarachai Kiratisin; Rodrigo E. Mendes; Diana Panesso; Kavindra V. Singh; Cesar A. Arias; University of Texas Medical School at Houston; Universidad El Bosque; Mahidol University; JMI Laboratories IncorporatedNonmutational resistance to linezolid is due to the presence of cfr, which encodes a methyltransferase responsible for methylation of A2503 in the 23S rRNA. The cfr gene was first described in animal isolates of staphylococci, and more recently..., it has been identified in Staphylococcus aureus from human clinical infections, including in an outbreak of methicillin-resistant S. aureus. In enterococci, cfr has been described in an animal isolate of Enterococcus faecalis from China. Here, we reportPublication Metadata only Qinghaosu in combinations(1998-12-01) N. J. White; Mahidol Universitydrugs that we do have available. Although in experimental animals combinations have been shown unequivocally to delay the onset of resistance, this has not yet been proved formally in human malaria. Yet formal proof is extremely difficult to obtain... antimalarial drugs. Those drugs with a particularly vulnerable profile, in which a single or double point mutation confers high level resistance, should not be deployed alone and should always be combined with an artemisinin derivative.Publication Metadata only Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53(2010-12-01) Yi Zhong; Chutwadee Krisanapun; Seong Ho Lee; Thararat Nualsanit; Carl Sams; Penchom Peungvicha; Seung Joon Baek; University of Tennessee, Knoxville; Shuguang Hospital; Srinakharinwirot University; Mahidol Universitytelangiectasia mutated (ATM), play an important role in activating these proteins. The data generated by in vitro experiments were confirmed in an animal study using APCMIN+mice. Apigenin is able to reduce polyp numbers, accompanied by increasing p53 activation... through phosphorylation in animal models. Our data suggest apparent beneficial effects of apigenin on colon cancer. © 2010 Elsevier Ltd. All rights reserved.Publication Metadata only Innovative Therapies for Hemoglobin Disorders(2020-10-01) Karine Sii-Felice; Olivier Negre; Christian Brendel; Alisa Tubsuwan; Eglantine Morel-à-l’Huissier; Camille Filardo; Emmanuel Payen; Universite Paris-Saclay; Mahidol University; Harvard Medical School; Biotherapy Partners SASfor high-level expression of the therapeutic gene, and cell-specific transgene expression. It took more than 40 years for scientists and physicians to advance from the cloning of globin gene and discovering globin gene mutations to improving our... understanding of the pathophysiological mechanisms involved, the detection of genetic modifiers, the development of animal models and gene transfer vectors, comprehensive animal testing, and demonstrations of phenotypic improvement in clinical trialsItem Metadata only Activation of GABA transmission by clonazepam reverses the autistic-like phenotypes of the Cav3.2 knockout mice(2025-01-01) Liang S.F.; Ming Y.; Huang H.T.; Lo R.Y.; Chompoopong S.; Chen C.C.; Liu I.Y.; Liang S.F.; Mahidol University, animal and molecular studies investigating the underlying mechanism in ASD patients with CACNA1H mutations are lacking. In this study, we performed a series of behavioral assays to phenotype the Cav3.2 systemic knockout (Cav3.2KO) mice. The Cav3.2KO mice.... To date, there are no disease-modifying, mechanism-targeted treatments approved for core ASD symptoms. In human studies, loss-of-function mutations in the CACNA1H gene, which encodes the T type Cav3.2 calcium channel, have been associated with ASD. HoweverPublication Metadata only Outbreak control and viral evolution of the highly pathogenic H5N1 avian influenzain Thailand(2013-03-01) Witthawat Wiriyarat; Kridsada Chaichoune; Parntep Ratanakorn; Prasert Auewarakul; Mahidol Universityfarming, resulting in massive economic loss. After 2006, sporadic cases occurred seasonally in backyard poultry in certain repeated outbreak areas involving limited number of poultry. The last animal outbreak was reported in 2008, and the last indigenous... period and no known human-adapted mutations were observed. Similarity of viral sequences among outbreak seasons indicated that the virus was maintained in a local reservoir between outbreak seasons. Virus of similar lineage was occasionally isolated from