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Publication Metadata only Artemisinin and multidrug-resistant Plasmodium falciparum - a threat for malaria control and elimination(2021-10-01) Mehul Dhorda; Chanaki Amaratunga; Arjen M. Dondorp; Faculty of Tropical Medicine, Mahidol University; Nuffield Department of Medicineresistance and approaches to counter multidrug-resistant falciparum malaria. RECENT FINDINGS: An aggressive malaria elimination programme in the GMS has helped prevent the spread of drug resistance to neighbouring countries. However, parasites carrying.... Treatment strategies designed to prevent the emergence and spread of multidrug resistance must be considered, including deployment of triple drug combination therapies and multiple first-line therapies.Publication Metadata only Comparative in vitro activity of sitafloxacin against multidrug-resistant and carbapenem-resistant acinetobacter baumannii clinical isolates in Thailand(2020-01-01) Taniya Paiboonvong; Vipavee Rodjun; Jantana Houngsaitong; Mullika Chomnawang; Preecha Montakantikul; Suvatna Chulavatnatol; Siam University; Mahidol University© 2020 Faculty of Pharmacy. The rapid emergence of multidrug-resistant Acinetobacter baumannii (MDRAB) is recognized as a significant health problem worldwide, including Thailand. Due to a limitation of treatment option, a new antimicrobial agent... and compare that with other antimicrobial agents against A. baumannii clinical isolates, focusing on multidrug-resistant A. baumannii and carbapenem-resistant A. baumannii (MDR-CRAB). All 350 A. baumannii clinical isolates were collected from thirteen tertiaryPublication Metadata only In vitro susceptibility testing of levofloxacin and ofloxacin by microtiter plate alamar blue against multidrug and non multidrug resistant Mycobacterium tuberculosis in Thailand(2001-09-01) Roongnapa Pracharktam; Kanung Angkananukool; Asda Vibhagool; Mahidol UniversityAntituberculous drugs for current therapy of multidrugs resistant tuberculosis (MDR-TB) are limited. The in vitro susceptibility of Mycobacterium tuberculosis (MTB) as well as MDRTB with other antibiotic drugs were determined in order to findPublication Metadata only Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro(2006-12-01) S. Nakornchai; P. Konthiang; Mahidol UniversityAzithromycin, an azalide analog of erythromycin was assayed for its in vitro activity against multidrug-resistant Plasmodium falciparum K1 strain by measuring the3H-hypoxanthine incorporation. Azithromycin caused inhibitory effects on the parasite... might inhibit the ability to treat malaria patients with chloroquine-azithromycin and chloroquine-erythromycin in areas of drug-resistant. The best drug combinations against multidrug-resistant P. falciparum are quinine-azithromycin and quininePublication Metadata only Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates(2010-09-01) Pattarachai Kiratisin; Anucha Apisarnthanarak; Srirumpa Kaewdaeng; Mahidol University; Faculty of Medicine, Thammasat UniversityTreatment options for multidrug-resistant (MDR) and extensively drug-resistant (XDR) Acinetobacter baumannii have been seriously limited and may require combination antimicrobial therapy. In this study, we searched for synergistic activity between... that combination of each carbapenem with cefoperazone/sulbactam, based on the Etest method, demonstrated synergy more frequently (17.5-32.5%) than the other tested agents, which may suggest a role in combination therapy against highly resistant A. baumannii. © 2010Publication Metadata only Quinolones and multidrug-resistant tuberculosis(1999-08-06) Khun Nanta Maranetra; Mahidol University; Faculty of Medicine, Siriraj Hospital, Mahidol UniversityThe prevalence of initial resistance of multidrug-resistant tuberculosis (MDR-TB) to at least isoniazid (INH) and rifampicin (RFP) in Thailand during the period 1993-1997 is reported; in this era, trends for INH + RFP + streptomycin (SM... discussed. The role of ofloxacin in MDR-TB is presented, with results from a study performed by the Thailand CDC showing that the percentage of strains resistant to ofloxacin was 4.3%, and to ciprofloxacin was 8.3%. The resistance to both ofloxacinPublication Metadata only Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand(1999-01-01) Sansanee C. Chaiyaroj; Akanit Buranakiti; Pornpimon Angkasekwinai; Sornchai Looareesuwan; Alan F. Cowman; Mahidol University; Walter and Eliza Hall Institute of Medical ResearchResistance to quinoline-containing compound has been associated with the Plasmodium falciparum multidrug resistance 1 (pfmdr1) gene. We analyzed wild P. falciparum isolates with high levels of chloroquine and mefloquine resistance... for their macrorestriction maps of chromosome 5 and sequence of pfmdr1. Two types of chromosome 5 amplification were found. Eleven of 62 resistant isolates displayed Bgl I fragments larger than 100 kb. Twenty-nine isolates possessed multiple copies of the fragments. WePublication Metadata only Potentiation of antimalarial drug action by chlorpheniramine against multidrug-resistant Plasmodium falciparum in vitro(2006-09-01) Sunan Nakornchai; Phattanapong Konthiang; Mahidol UniversityChlorpheniramine, a histamine H1 receptor antagonist, was assayed for in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum K1 strain and chloroquine-resistant P. falciparum T9/94 clone, by measuring the3H-hypoxanthine... incorporation. Chlorphenirame inhibited P. falciparum K1 and T9/94 growth with IC50values of 136.0 ± 40.2 μM and 102.0 ± 22.6 μM respectively. A combination of antimalarial drug and chlorpheniramine was tested against resistant P. falciparum in vitroPublication Metadata only In vitro activity and MIC of sitafloxacin against multidrug- resistant and extensively drug-resistant mycobacterium tuberculosis isolated in Thailand(2018-01-01) Manoon Leechawengwongs; Therdsak Prammananan; Sarinya Jaitrong; Pamaree Billamas; Nampueng Makhao; Nongnard Thamnongdee; Arirat Thanormchat; Arisa Phurattanakornkul; Somcharn Rattanarangsee; Chate Ratanajaray; Areeya Disratthakit; Angkana Chaiprasert; Thailand National Center for Genetic Engineering and Biotechnology; Faculty of Medicine, Siriraj Hospital, Mahidol University; Vichaiyut Hospital; Siriraj Foundation) is a new fluoroquinolone with in vitro activity against a broad range of bacteria, including M. tuberculosis. This study aimed to determine the in vitro activity of STFX against all groups of drug-resistant strains, including multidrug-resistant M... the groups of drug-resistant M. tuberculosis strains and should be considered a new repurposed drug for treatment of multidrug-resistant and extensively drug-resistant TB.Publication Metadata only Comment on: High tigecycline resistance in multidrug-resistant Acinetobacter baumannii [3](2007-07-01) Visanu Thamlikitkul; Surapee Tiengrim; Chanwit Tribuddharat; Mahidol University