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Publication Open Access Participants’ perceptions and understanding of a malaria clinical trial in Bangladesh(2014) Debashish Das; Cheah, Phaik Yeong; Fateha Akter; Dulal Paul; Akhterul Islam; Rasheda Samad; Ridwanur Rahman; Amir Hossain; Arjen Dondorp; Day, Nicholas P; White, Nicholas J; Mahtabuddin Hasan; Aniruddha Ghose; Ashley, Elizabeth A; Abul Faiz; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research UnitBackground: Existing evidence suggests that there is often limited understanding among participants in clinical trials about the informed consent process, resulting in their providing consent without really understanding the purpose of the study..., specific procedures, and their rights. The objective of the study was to determine the subjects’ understanding of research, perceptions of voluntariness and motivations for participation in a malaria clinical trial. Methods: In this study semi-structuredPublication Open Access International health research monitoring: exploring a scientific and a cooperative approach using participatory action research.(2014-02-17) Chantler, Tracey; Cheah, Phaik Yeong; Miiro, George; Viriya Hantrakum; Nanvubya, Annet; Ayuo, Elizabeth; Kivaya, Esther; Kidola, Jeremiah; Kaleebu, Pontiano; Parker, Michael; Njuguna, Patricia; Ashley, Elizabeth; Guerin, Philippe J.; Lang, Trudie; Lang, Trudie; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit.OBJECTIVES: To evaluate and determine the value of monitoring models developed by the Mahidol Oxford Tropical Research Unit and the East African Consortium for Clinical Research, consider how this can be measured and explore monitors... and transparency. In terms of practice the primary purpose of monitoring was defined as improving the conduct of health research and increasing the capacity of researchers and trial sites. CONCLUSIONS: The models studied utilise internal and network widePublication Open Access Primaquine: the risks and the benefits(2014) Ashley, Elizabeth A; Judith Recht; White, Nicholas J; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit,428 (upper 95% CI: one in 407,807). All but one death followed multiple dosing to prevent vivax malaria relapse. Review of dose-response relationships and clinical trials of primaquine in G6PD deficiency suggests that the currently recommended WHO singlePublication Open Access Clinical trials of artesunate plus sulfadoxine‑pyrimethamine for Plasmodium falciparum malaria in Afghanistan: maintained efficacy a decade after introduction(2016) Ghulam Rahim Awab; Mallika Imwong; Sasithon Pukrittayakamee; Fazel Alim; Warunee Hanpithakpong; Joel Tarning; Dondorp, Arjen M.; Day, Nicholas P. J.; White, Nicholas J.; Woodrow, Charles J.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)in all the trials, with an adequate clinical and parasitological response (ACPR) of more than 95 % in all groups and trial stages. Genotyping for drug-resistance alleles at dhfr indicated fixation of the S108 N mutation and a prevalence of the C59R...Background: Combination therapy with artesunate plus sulfadoxine-pyrimethamine (SP) was adopted as recommended treatment for Plasmodium falciparum infection in Afghanistan in 2003. Methods: A series of prospective clinical studies examiningPublication Open Access Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial(2014) Jones, Deborah; Peltzer, Karl; Weiss, Stephen M; Sifunda, Sibusiso; Dwane, Ntabozuko; Ramlagan, Shandir; Cook, Ryan; Matseke, Gladys; Maduna, Vincent; Spence, Andrew; Mahidol University. ASEAN Institute for Health Developmentfor containing the epidemic among the most vulnerable populations in rural South Africa: HIV-positive pregnant women and their infants. Trial registration: ClinicalTrials.gov NCT02085356 (registration date: 10 March 2014).Publication Open Access Screening and brief interventions for hazardous and harmful alcohol use among patients with active tuberculosis attending primary public care clinics in South Africa: results from a cluster randomized controlled trial(2013) Peltzer, Karl; Naidoo, Pamela; Louw, Julia; Matseke, Gladys; Zuma, Khangelani; Mchunu, Gugu; Tutshana, Bomkazi; Mabaso, Musawenkosi; Mahidol University. ASEAN Institute for Health Developmentand misusing alcohol are not easily cured from TB. With this in mind, the primary purpose of this cluster randomized controlled trial was to provide screening for alcohol misuse and to test the effectiveness of brief interventions in reducing alcohol intake... in those patients with active TB found to be misusing alcohol in primary public health care clinics in three districts in South Africa. Methods Within each of the three provinces targeted, one district with the highest TB burden was selectedPublication Open Access Ethical considerations in malaria research proposal review: empirical evidence from 114 proposals submitted to an Ethics Committee in Thailand(2015) Pornpimon Adams; Sukanya Prakobtham; Chanthima Limphattharacharoen; Pitchapa Vutikes; Srisin Khusmith; Krisana Pengsaa; Polrat Wilairatana; Jaranit Kaewkungwal; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Hygienetrials (13 %), laboratory studies (24 %) and epidemiological studies (46 %). They included multi-site (13 %) and international studies (4 %), and those involving minority populations (28 %), children (17 %) and pregnant women (7 %). Drug trials hadPublication Open Access A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection.(2008 October) W Nittayananta; TA DeRouen; P Arirachakaran; T Laothumthut; K Pangsomboon; S Petsantad; V Vuddhakul; H Sriplung; S Jaruratanasirikul; MD MartinOBJECTIVE: To determine if chlorhexidine can be used as an intervention to prolong the time to relapse of oral candidiasis. SUBJECTS AND METHODS: A double-blinded randomized clinical trial was performed in 75 HIV?AIDS subjects with oralPublication Open Access Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis(2015) Jatupon Kongtharvonskul; Thunyarat Anothaisintawee; McEvoy, Mark; Attia, John; Patarawan Woratanarat; Ammarin Thakkinstian; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Section for Clinical Epidemiology and BiostatisticsBackground: To conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with the aims of comparing relevant clinical outcomes (that is, visual analog scores (VAS), total and sub-Western Ontario and Mc..., using PubMed and Scopus search engines and included RCTs or quasi-experimental designs comparing clinical outcomes between treatments. Data were extracted from original studies. A network meta-analysis was performed by applying weight regressionPublication Open Access Clinical prediction score for superficial surgical site infection after appendectomy in adults with complicated appendicitis(2018) Pinit Noorit; Boonying Siribumrungwong; Ammarin Thakkinstian; Mahidol University. Faculty of Medicine, Ramathibodi Hospital. Section for Clinical Epidemiology and BiostatisticsBackground: Superficial surgical site infection (SSI) is common after appendectomy. This study aims to determine a clinical prediction score for SSI after appendectomy in complicated appendicitis. Methods: Data from randomized controlled trial... of delayed versus primary wound closures in complicated appendicitis was used. Nineteen patient- and operative-related predictors were selected in the logit model. Clinical prediction score was then constructed using coefficients of significant predictors