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Publication Open Access The economic evaluation of human papillomavirus vaccination strategies against cervical cancer in women in Lao PDR: a mathematical modelling approach(2016) Phetsavanh Chanthavilay; Reinharz, Daniel; Mayfong Mayxay; Keokedthong Phongsavan; Marsden, Donald E.; Moore, Lynne; White, Lisa J.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit, vaccination against this virus may lead to a reduction in these types of cancer. The study described here is the first to compare the cost-effectiveness of different HPV vaccination options in Lao PDR. Methods: A dynamic compartment model was created...) averted. Results: In base case analyses, according to the WHO definition of cost-effectiveness thresholds, vaccinating 10-year-old girls was very cost-effective. Adding a catch-up vaccination element for females aged 11–25 years was also very costPublication Open Access Preliminary evaluation of the analgesic and anti-inflammatory effects of Tacca integrifolia in rodents(2015) Thatree Autsavakitipong; Parirat Khonsung; Ampai Panthong; Natthakarn Chiranthanut; Puongtip Kunanusorn; Narong Nuntasaen; Thaworn Jaipetch; Samreang Bunteang; Vichai Reutrakul; Mahidol University. Kanchanaburi Campus. Center for Innovation Chemistryby acetic acid injection (65.9%) but did not exhibit effect in tail flick test in rats. These findings suggest that analgesic mechanism of TIE may act via peripherally pathway. The study of anti-inflammatory effect showed that TIE significantly... inhibited ear edema induced by EPP. TIE (200 mg/kg, PO) inhibited paw edema induced by carrageenan (55.5%) and arachidonic acid (48.6%) but had no effect on cotton-induced granuloma formation in rats. In conclusion, the ethyl acetate extract of leafPublication Open Access Cytotoxicity evaluation of Clinacanthus nutans through dimethylthiazol diphenyltetrazolium bromide and neutral red uptake assays.(2016-01) Suwanna Korsuwannawong; สุวรรณา ก่อสุวรรณวงศ์; La‑Ongthong Vajrabhaya; ละอองทอง วัชราภัย; Suwanna Korsuwannawong; Mahidol University. Faculty of Dentistry. Research Officeto good correlation for the evaluation of the cytotoxicity of C. nutans .Publication Open Access Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers(2016) Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning; Mahidol University. Faculty of Tropical Medicine. Mahidol‑Oxford Tropical Medicine Research Unitto 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokinetic properties... properties of artemisinin. The results from the traditional bioequivalence evaluation were comparable with results obtained from mixed-effects modellingPublication Open Access Effects of disinfection procedures on surface quality of compound impressions and the resultant gypsum casts.(2014-01) Potchaman Sinavarat; พจมาน ศรีนวรัตน์; Saysana Visayrath; Potchaman Sinavarat; พจมาน ศรีนวรัตน์; Mahidol University. Faculty of Dentistry. Department of ProsthodonticsObjective: To evaluate the effects of disinfection procedures on the detail reproduction of type I impression compound and the surface quality of the gypsum casts poured against the disinfected impressions. Materials and methods: To make...-disinfected impressions served as controls. Each impression was visually evaluated for detail reproduction before and after disinfection and then poured with Type III dental stone. The resultant stone casts were evaluated for detail reproduction. To assessPublication Open Access Malaria community health workers in Myanmar: a cost analysis(2016) Shwe Sin Kyaw; Drake, Tom; Aung Thi; Myat Phone Kyaw; Thaung Hlaing; Smithuis, Frank M.; White, Lisa J.; Lubell, Yoel; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unitremoteness and the approach to monitoring and evaluation. The estimates provide information to policy makers and CHW programme planners in Myanmar as well as supporting economic evaluations of their cost-effectiveness.Publication Open Access Evaluation of mass drug administration in the program to control imported lymphatic filariasis in Thailand(2015) Tanaporn Toothong; Mathuros Tipayamongkholgul; Nawarat Suwannapong; Saravudh Suvannadabba; Mahidol University. Faculty of Public Health. Department of Epidemiologybe compromised. This study aimed to evaluate DEC administration and its barriers in such areas. Methods: A cross-sectional study with two-stage stratified cluster sampling was conducted. We selected Myanmar immigrants aged >18 years from factory and fishery... (adjusted OR = 1.62; 95 % CI = 1.04–2.52) and living in a fishery area (adjusted OR = 1.57; 95 % CI = 1.04–2.52). Incorrect perceptions about the side-effects of DEC also obstructed DEC access for Myanmar immigrants. All positive LF antigenic immigrantsPublication Open Access L-carnitine supplemented extender improves cryopreserved-thawed cat epididymal sperm motility(2014-06) Manee-In S; Parmornsupornvichit S; Kraiprayoon S; Tharasanit T; Chanapiwat P; Kaeoket K; Mahidol University. Faculty of Veterinary Science. Department of Clinical Sciences and Public Health MedicineCryopreservation of epididymal sperm is an effective technique to preserve genetic materials of domestic cats and wild felids when they unexpectedly die. However, this technique inevitably causes detrimental changes of cryopreserved-thawed... spermatozoa, for example, by physical damage and excessive oxidative stress. L-carnitine is an antioxidant that has been used to improve sperm motility in humans and domestic animals. This study aimed to investigate the effects of L-carnitine on cat epididymalPublication Open Access Analysis of 2009 pandemic influenza A/H1N1 outcomes in 19 European countries: association with completeness of national strategic plans(2014-04-21) Aronrag Meeyai; Cooper, Ben S; Coker, Richard; อรุณรักษ์ คูเปอร์ มีใย; Aronrag Meeyai; Mahidol university. Faculty of Public Health. Department of Epidemiology.Objective: To describe changes in reported influenza activity associated with the 2009 H1N1 pandemic in European countries and determine whether there is a correlation between these changes and completeness of national strategic pandemic preparedness. Design: A retrospective correlational study. Setting: Countries were included if their national strategic plans had previously been analysed and if weekly influenza-like illness (ILI) data from sentinel networks between week 21, 2006 and week 20, 2010 were more than 50% complete. Outcome measures: For each country we calculated three outcomes: the percentage change in ILI peak height during the pandemic relative to the prepandemic mean; the timing of the ILI peak and the percentage change in total cases relative to the prepandemic mean. Correlations between these outcomes and completeness of a country’s national strategic pandemic preparedness plan were assessed using the Pearson product–moment correlation coefficient. Results: Nineteen countries were included. The ILI peak occurred earlier than the mean seasonal peak in 17 countries. In 14 countries the pandemic peak was higher than the seasonal peak, though the difference was large only in Norway, the UK and Greece. Nine countries experienced more total ILI cases during the pandemic compared with the mean for prepandemic years. Five countries experienced two distinct pandemic peaks. There was no clear pattern of correlation between overall completeness of national strategic plans and pandemic influenza outcome measures and no evidence of association between these outcomes and components of pandemic plans that might plausibly affect influenza outcomes ( public health interventions, vaccination, antiviral use, public communication). Amongst the 17 countries with a clear pandemic peak, only the correlation between planning for essential services and change in total ILI cases significantly differed from zero: correlation coefficient (95% CI) 0.50 (0.02, 0.79). Conclusions: The diversity of pandemic influenza outcomes across Europe is not explained by the marked variation in the completeness of pandemic plans.Publication Open Access The sperm DNA damage after cryopreservation of boar semen in relation to post-thawed semen qualities, antioxidant supplementation and boars effects.(2010) Panida Chanapiwat; Kampon Kaeoket; Padet Tummaruk; Mahidol University. Faculty of Veterinary ScienceThe objectives of the present study were to evaluate the damage of DNA of the frozen-thawed (FT) boar spermatozoa and to investigate the effect of various concentrations of L-cysteine supplementation on the sperm DNA damage. A total of 104... spermatozoa was relatively low. No adverse effect of L-cysteine supplementation up to 10 mM on the damage of the sperm DNA was found. Boar characteristic is the most important factor affecting the damage of the sperm DNA.