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Publication Open Access Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells(2014) Kamolporn Amornsupak; Tonkla Insawang; Peti Thuwajit; Pornchai O-Charoenrat; Eccles, Suzanne A.; Chanitra Thuwajit; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of ImmunologyBackground: Cancer-associated fibroblasts and high mobility group box 1 (HMGB1) protein have been suggested to mediate cancer progression and chemotherapy resistance. The role of such fibroblasts in HMGB1 production in breast cancer is unclear.... This study aimed to investigate the effects of cancer-associated fibroblasts on HMGB1 expression in breast cancer cells and its role in chemotherapeutic response. Methods: Breast cancer-associated fibroblasts (BCFs) and non-tumor-associated fibroblastsPublication Open Access Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma(2013-05-15) Pasra Arnutti; ภัสรา อาณัติ; Manas Kotepui; มนัส โคตรพุ้ย; Wichitra Asanprakit; Phaibul Punyarit; Porntip Chavalitshewinkoon-Petmitr; พรทิพย์ ชวลิตรชีวินกุล เพ็ชรมิตร; Talabporn Harnroongroj; ตรับพร หาญรุ่งโรจน์; Songsak Petmitr; ทรงศักดิ์ เพ็ชรมิตร; Songsak Petmitr; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Nutrition & Food Science.; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine & Genetics.; Mahidol University. Faculty of Tropical Medicine. Department of Protozoology.of the molecular basis of IDCs, allow for examination of specific markers for diagnosis, and provide novel targets for therapy. This study aimed to detect the whole transcript expression of approximately 35,000 target genes in Thai breast cancer patients, using...Breast cancer is the most common cancer affecting women worldwide including Thailand. Whole transcription profiles of invasive ductal breast carcinoma (IDC) obtained by oligonucleotide microarray should lead to a better understandingPublication Open Access ความสัมพันธ์ระหว่างการสนับสนุนทางสังคมสถานภาพทางการเงินพฤติกรรมสร้างเสริมสุขภาพและคุณภาพชีวิตในสตรีมะเร็งเต้านมระหว่างได้รับรังสีรักษา(2557) คนึงนิจ พงศ์ถาวรกมล; Kanaungnit Pongthavornkamol; พิจิตรา เล็กดํารงกุล; Pichitra Lekdamrongkul; พรพรรณ วนวโรดม; Pornpun Wanawarodom; วันทกานต์ ราชวงศ์; Wontakarn Ratchawong; มหาวิทยาลัยมหิดล. คณะพยาบาลศาสตร์; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์ศิริราชพยาบาล.Conclusion and recommendations: Nurses should assess health-promoting behaviors andsources of social support of women with breast cancer during radiation treatment. Quality of life shouldalso be assessed in those patients with low income in order....Design: Descriptive correlational research.Methods: The study sample consisted of 88 women diagnosed with breast cancer who werereceiving radiation therapy at radiation department of one university hospital in Bangkok. The subjectswere recruitedPublication Open Access ALK-rearranged pulmonary adenocarcinoma in Thai Patients: From diagnosis to treatment efficacy(2016) Pimpin Incharoen; Thanyanan Reungwetwattana; Sakditad Saowapa; Kaettipong Kamprerasart; Duangjai Pangpunyakulchai; Lalida Arsa; Artit Jinawath; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Pathologytherapy provided treatment benefit in ALKrearranged adenocarcinoma patients especially in advanced stages of the disease....Background: Anaplastic lymphoma kinase (ALK) gene rearrangement is detected in 3 % to 13 % of non-small cell lung carcinoma patients, and these patients benefit from ALK inhibitors. The aim of this study was to determine the prevalencePublication Open Access Origin of aromatase inhibitory activity via proteochemometric modeling(2016-04) Saw Simeon; Ola Spjuth; Maris Lapins; Chanin Nantasenamat; Jarl ES Wikberg; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical InformaticsAromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit... into the mechanisms of aromatase inhibitory activity that could aid in the design of novel potent AIs as breast cancer therapeutic agents.Publication Open Access Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells(2015-04-08) Waraporn Chan-on; Nguyen Thi Bich Huyen; Napat Songtawee; Wilasinee Suwanjang; Supaluk Prachayasittikul; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical InformaticsPurpose: Fork head box M1 (FoxM1) is an oncogenic transcription factor frequently elevated in numerous cancers, including cholangiocarcinoma (CCA). A growing body of evidence documents its diverse functions contributing to tumorigenesis and cancerPublication Open Access ภาวะโภชนาการและปัจจัยที่มีผลต่อการบริโภคอาหารของผู้ป่วยระยะสุดท้าย ที่มารับบริการคลินิกดูแลและบรรเทาอาการ(2559) สุมนทิพย์ นาควิจิตร; กิติพล นาควิโรจน์; พรพิมล โอเจริญ; ศศปิรียากานต์ มิ่งวงศ์; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. ภาควิชาเวชศาสตร์ครอบครัวof 51-60 years of age 30.1 per one-hundred, couple status 66 per one-hundred, universal health care user 48.5 per onehundred, house wife or unemployed 23 of one-hundred, those completed primary school 36.9 of onehundred, patients with lung cancer 32... of one-hundred, stomach and intestines and anus complications 15.5 per one-hundred, patients with liver cancer 6.8 per one-hundred, patients with acceptable weight 38.8 per one-hundred, patients with less than acceptable weight 31.1. The average caloriePublication Open Access Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma(2010) Jongkonnee Thanasai; Temduang Limpaiboon; Patcharee Jearanaikoon; Banchob Sripa; Chawalit Pairojkul; Srisurang Tantimavanich,; Masanao MiwaAIM: To evaluate the role of thymidine phosphorylase (TP) in cholangiocarcinoma using small interfering RNA (siRNA). METHODS: A human cholangiocarcinoma-derived cell line KKU-M139, which has a naturally high level of endogenous TP, had TP expression transiently knocked down using siRNA. Cell growth, migration, in vitro angiogenesis, apoptosis, and cytotoxicity were assayed in TP knockdown and wild-type cell lines. RESULTS: TP mRNA and protein expression were decreased by 87.1% ± 0.49% and 72.5% ± 3.2%, respectively, compared with control cells. Inhibition of TP significantly decreased migration of KKU-M139, and suppressed migration and tube formation of human umbilical vein endothelial cells. siRNA also reduced the ability of TP to resist hypoxia-induced apoptosis, while suppression of TP reduced the sensitivity of KKU-M139 to 5-fluorouracil. CONCLUSION: Inhibition of TP may be beneficial in decreasing angiogenesis-dependent growth and migration of cholangiocarcinoma but may diminish the response to 5-fluorouracil chemotherapy.Publication Open Access Clinically unapparent infantile thiamin deficiency in Vientiane, Laos.(2011-02-22) Khounnorath, Sengmanivong; Chamberlain, Karen; Taylor, Ann M.; Soukaloun, Douangdao; Mayxay, Mayfong; Lee, Sue J.; Phengdy, Bounthom; Luangxay, Khonsavanh; Sisouk, Kongkham; Soumphonphakdy, Bandit; Latsavong, Khaysy; Akkhavong, Kongsin; White, Nicholas J.; Newton, Paul N.; Newton, Paul N.; Mahidol University. Faculty of TropicalMedicine. Mahidol-Oxford Tropical Medicine Research Unit.BACKGROUND: Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome. METHODOLOGY/PRINCIPAL FINDINGS: A cohort of 778 sick infants admitted during one year without clinical evidence of beriberi were studied prospectively and erythrocyte transketolase assays (ETK) performed. Biochemical thiamin deficiency was defined both in terms of the activation coefficient (α>31%) and basal ETK activity <0.59 micromoles/min/gHb. Of the 778 infants, median (range) age was 5 (0-12) months, 79.2% were breastfed, 5.1% had α>31% and 13.4 % basal ETK<0.59 micromoles/min/gHb. Infants≥2 months old had a higher frequency of biochemical markers of thiamin deficiency. Mortality was 5.5% but, among infants ≥2 months old, mortality was higher in those with basal ETK<0.59 micromoles/min/gHb (3/47, 6.4%) than in those with basal ETK≥0.59 micromoles/min/gHb (1/146, 0.7%) (P=0.045, relative risk=9.32 (95%CI 0.99 to 87.5)). Multivariate regression analysis indicated that infant age≥2 months and fewer maternal years of schooling were independently associated with infant basal ETK<0.59 micromoles/min/gHb. CONCLUSIONS/SIGNIFICANCE: Clinically unapparent thiamin deficiency is common among sick infants (≥2 months old) admitted to hospital in Vientiane. This may contribute to mortality and a low clinical threshold for providing thiamin to sick infants may be needed.Publication Open Access Thermoregulatory correlates of nausea in rats and musk shrews(2014) Sukonthar Ngampramuan; Matteo Cerri; Flavia Del Vecchio; Corrigan, Joshua J; Amornrat Kamphee; Dragic, Alexander S; Rudd, John A; Romanovsky, Andrej A; Eugene Nalivaiko; Mahidol University. Institute of Molecular BiosciencesNausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their efficacy is questionable. Currently, the development of new compounds...-HT3 receptor antagonist, which is used to treat nausea in patients in chemo- or radiation therapy, attenuated hypothermia by ~30%. In shrews, motion sickness was induced by a cyclical backand-forth motion (4 cm, 1 Hz, 15 min) and confirmed