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Publication Open Access Factors related to the Acceptance of the New Antenatal Care Protocol among the Health Personnel in Suphan Buri Province, Thailand(2007) Trin Tuyet Anh; Sirikul Isaranuruk; Jiraporn Chompikul; Mahidol University. ASEAN Institute for Health DevelopmentA cross-sectional study was conducted to determine the factors related to the acceptance of the new antenatal care (ANC) protocol proposed by WHO among the health personnel in Suphan Buri province. The sample consisted of 1?9 personnel who were... working in ANC field in this province. Data were collected from ?th January to 29th January 2OO7 by using self-administered questionnaires accompanied with the comparison form between the new protocol and the conventional one. Data analysis was performedPublication Open Access Is your ethics committee efficient? Using "IRB Metrics" as a self-assessment tool for continuous improvement at the Faculty of Tropical Medicine, Mahidol University, Thailand.(2014-11-18) Pornpimon Adams; พรพิมล อดัมส์; Jaranit Kaewkungwal; จรณิต แก้วกังวาน; Chanthima Limphattharacharoen; Sukanya Prakobtham; สุกัญญา ประกอบธรรม; Krisana Pengsaa; ฤษณา เพ็งสา; Srisin Khusmith; ศรีสิน คูสมิทธิ์; Jaranit Kaewkungwal; Mahidol University. Faculty of Tropical Medicine. Office of Research Services; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Hygiene; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Pediatrics; Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology-outcome measurement model. To observe trends in the indicators evaluated, data related to all protocols submitted to the two panels of the FTM-EC (clinical and non-clinical), between January 2010-September 2013, were extracted and analyzed. Quantitative... information based on IRB Metrics structure-process-outcome illuminates different areas for internal-process improvement. Ethical issues raised with researchers by the IRB, which were associated with the duration of the approval process in protocol reviewPublication Open Access Ethical considerations in malaria research proposal review: empirical evidence from 114 proposals submitted to an Ethics Committee in Thailand(2015) Pornpimon Adams; Sukanya Prakobtham; Chanthima Limphattharacharoen; Pitchapa Vutikes; Srisin Khusmith; Krisana Pengsaa; Polrat Wilairatana; Jaranit Kaewkungwal; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Hygienefor proposals involving new specimen collection. Studies involving stored data and specimens tended to attract more issues around privacy and confidentiality. Proposals involving minority populations were more likely to raise issues than those that didPublication Open Access A time course analysis of the electrophysiological properties of neurons differentiated from human induced Pluripotent Stem Cells (iPSCs)(2014) Pre Deborah; Nestor, Michael W.; Sproul, Andrew A.; Jacob Samson; Koppensteiner Peter; Vorapin Chinchalongporn; Zimmer Matthew; Yamamoto Ai; Noggle, Scott A.; Mahidol University. Institute of Molecular Biosciences. Research Center for NeuroscienceMany protocols have been designed to differentiate human embryonic stem cells (ESCs) and human induced pluripotent stem cells (iPSCs) into neurons. Despite the relevance of electrophysiological properties for proper neuronal function, littlePublication Open Access Genetic marker suitable for identification and genotyping of Plasmodium ovale curtisi and Plasmodium ovale wallikeri.(2013-12) Naowarat Tanomsing; เนาวรัตน์ ถนอมสิงห์; Mallika Imwong; มัลลิกา อิ่มวงศ์; Sutherland, Colin J.; Dolecek,Christiane; Hien,Tran Tinh; Nosten, Francois; Day, Nicholas P. J.; White, Nicholas J.; Snounouh, Georges; Mallika Imwong; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.; Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.We present a seminested PCR method that specifically discriminates between Plasmodium ovale curtisi and P. ovale wallikeri with high sensitivity. The test is based on species-specific amplification of a size-polymorphic fragment of the tryptophan-rich antigen gene, potra, which also permits discrimination of intraspecific sequence variants at this locus.Publication Open Access Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial(2014) Jones, Deborah; Peltzer, Karl; Weiss, Stephen M; Sifunda, Sibusiso; Dwane, Ntabozuko; Ramlagan, Shandir; Cook, Ryan; Matseke, Gladys; Maduna, Vincent; Spence, Andrew; Mahidol University. ASEAN Institute for Health DevelopmentBackground: In rural South Africa, only two-thirds of HIV-positive pregnant women seeking antenatal care at community health centers took full advantage of ‘prevention of mother-to-child transmission’ (PMTCT) services in 2010. Studies generally support male involvement to promote PMTCT, but the nature and impact of that involvement is unclear and untested. Additionally, stigma, disclosure and intimate partner violence pose significant barriers to PMTCT uptake and retention in care, suggesting that male involvement may be ‘necessary, but not sufficient’ to reduce infant HIV incidence. This study expands on a successful United States President's Emergency Plan for AIDS Relief (PEPFAR)-supported PMTCT couples intervention pilot study conducted in the Mpumalanga province, targeting HIV-positive pregnant women and their partners, the primary objective being to determine whether male partner involvement plus a behavioral intervention will significantly reduce infant HIV incidence. Methods/design: The study follows a cluster randomized controlled design enrolling two cohorts of HIV-positive pregnant women recruited from 12 randomly assigned Community Health Centers (CHC) (six experimental, six control). The two cohorts will consist of women attending without their male partners (n = 720) and women attending with their male partners (n = 720 couples), in order to determine whether the influence of male participation itself, or combined with a behavioral PMTCT intervention, can significantly reduce infant HIV infection ante-, peri- and postnatally. Discussion: It is our intention to significantly increase PMTCT participation from current levels (69%) in the Mpumalanga province to between 90 and 95% through engaging women and couples in a controlled, six session ante- and postnatal risk-reducing and PMTCT promotion intervention addressing barriers to PMTCT (such as stigma, disclosure, intimate partner violence, communication, infant feeding practices and safer conception) that prevent women and men from utilizing treatment opportunities available to them and their infants. Based upon the encouraging preliminary results from our pilot study, successful CHC adoption of the program could have major public health policy implications for containing the epidemic among the most vulnerable populations in rural South Africa: HIV-positive pregnant women and their infants. Trial registration: ClinicalTrials.gov NCT02085356 (registration date: 10 March 2014).Publication Open Access Genetic diversity of Plasmodium vivax in Kolkata, India.(2006-08-14) Kim, Jung-Ryong; Mallika Imwong; มัลลิกา อิ่มวงศ์; Nandy, Amitabha; Kesinee Chotivanich; เกศินี โชติวานิช; Apichart Nontprasert; อภิชาต นนท์ประเสริฐ; Naowarat Tonomsing; Maji, Ardhendu; Addy, Manjulika; Day, Nick P.J.; White, Nicholas J.; Sasithon Pukrittayakamee; ศศิธร ผู้กฤตยาคามี; Mallika Imwong; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine. The genotyping protocols used in this study may be useful for differentiating re-infection from relapse and recrudescence in studies assessing of malarial drug efficacy in vivax malaria.Publication Open Access Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine.(2014-08-18) Zongo, Issaka; Some, Fabrice A.; Somda, Serge A. M.; Parikh, Sunil; Rouamba, Noel; Rosenthal, Philip J.; Tarning, Joel; Lindegardh, Niklas; Nosten, Franc¸ois; Oue´draogo, Jean Bosco; Oue´draogo, Jean Bosco; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Shoklo Malaria Research Unit.BACKGROUND: One promising new Artemisinin-based combination therapies (ACTs) is dihydroartemisinin-piperaquine (DHA-PQ). However, the pharmacokinetics of piperaquine and the relationship between drug levels and clinical efficacy are incompletely....001). CONCLUSION: DHA-PQ was effective for uncomplicated P. falciparum malaria treatment and offers an alternative to other ACTs. Recurrent malaria was mainly due to new infections after treatment and was correlated with low day 7 PQ concentration in the youngestPublication Open Access Improvement of culture conditions for long‑term in vitro culture of Plasmodium vivax(2015) Wanlapa Roobsoong; Tharinjaroen, Chayada S; Nattawan Rachaphaew; Porpimon Chobson; Louis Schofield; Liwang Cui; Adams, John H; Jetsumon Sattabongkot; Mahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unitthis system, three of 30 isolates could be maintained in vitro for over 26 months albeit parasite density is low. Conclusions: Based on the analysis of different culture variables, an improved and feasible protocol for continuous culture of P. vivaxPublication Open Access End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24-45 years of age.(2011-06-28) Castellsagué, X; Muñoz, N; Punnee Pitisuttithum; พรรณี ปิติสุทธิธรรม; Ferris, D; Monsonego, J; Ault, K; Luna, J; Myers, E; Mallary, S; Bautista, OM; Bryan, J; Vuocolo, S; Haupt, RM; Saah, A; Castellsagué, X; Mahidol University. Faculty of Tropical Medicine. Vaccine Trial Center.). The main analysis was conducted in a per-protocol efficacy population (that received three doses, was naive to the relevant HPV types at day 1, and remained free of infection through month 7). Efficacy was also estimated in other naive and non-naive... populations. RESULTS: Vaccine efficacy against the combined incidence of persistent infection, CIN/EGL related to HPV6/11/16/18 in the per-protocol population was 88.7% (95% CI: 78.1, 94.8). Efficacy for women who were seropositive and DNA negative