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Item Metadata only The effect of dietary fiber on hydrogen and methane production in vegetarians(Mahidol University. Mahidol University Library and Knowledge Center, 2003) Nantana Suppapitnarm; Prapaisri P. Sirichakwal; Prapasri Puwastien; Anadi NitithamyongItem Metadata only Lactose digestion and tolerance after yogurt tablet consumption in adolescents(Mahidol University. Mahidol University Library and Knowledge Center, 2000) Laong Kvammana; Prapaisri P. Sirichakwal; Prapasri Puwastien; Visith ChavasitItem Metadata only Elimination Diet Guided by Food-Specific IgG Antibodies Measurements in Chronic Adult Acne in Thailand: A Prospective RCT Study(2024-01-01) Maiprasert M.; Khunngam P.; Rakchart S.; Tovanabutr N.; Wanitphakdeedecha R.; Srinoulprasert Y.; Chai-Adisaksopha C.; Maiprasert M.; Mahidol UniversityBackground: Adult female acne is increasingly prevalent and significantly affects quality of life. Current treatments, including antibiotics and hormonal therapies, often yield varied efficacy and risks. While adult acne shares similarities... with adolescent acne, its pathogenesis involves genetic, hormonal, immune, and dietary factors. Emerging research implicates high glycemic load diets, milk proteins, and insulin/IGF1 signaling in exacerbating acne. Despite growing understanding, dietary influencesPublication Open Access Evaluation of a novel oral iron chelator 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (CM1) for treatment of iron overload in mice(2013) Somdet Srichairatanakool; Kanjana Pangjit; Chada Phisalaphong; Suthat Fucharoen; Mahidol University. Institute of Molecular Biosciences. Thalassemi a Research Centrerderivatives are being developed as a safer new chelator and in combined chelation therapy. We evaluated the iron-chelating activity of 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (CM1) in iron-loaded C57BL6 mice. The feeding of a ferrocene-supplemented... diet (Fe diet) to mice resulted in iron overload, detectable plasma nontransferrin-bound iron (NTBI) and labile plasma iron (LPI), and increases of red cell membrane iron, plasma malondialdehyde (MDA) and excessive tissue iron deposits. Like DFP, the CMPublication Open Access The Amelioration of Nutritional Status and Phase Angle, Safety, and Satisfaction in Tube-Fed Patients With Ready-to-Use Blenderized Diet With Chicken and Pumpkin(2019) Kulapong Jayanama; Piyanuch Maitreejorn; Thanwarin Tangsermwong; Pariya Phanachat; Prapimporn Chattranukulchai; กุลพงษ์ ชัยนาม; ปิยนุช ไมตรีจร; ธัญวรินทร์ ตั้งเสริมวงศ์; ปริย พรรณเชษฐ์; ประพิมพ์พร ฉัตรานุกูลชัย; พัชรวีร์ ทันละกิจ; ดรุณีวัลย์ วโรดมวิจิตร; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Chakri Naruebodindra Medical Institute; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Division of Nutrition and Dietetics; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Medicine; Ministry of Public Health. Pakphayun Hospital. Division of NutritionBackground: The requirement of a hospital-made, blenderized diet, as a generally used and complete polymeric formula, is increasing beyond supply availability and accessibility. A ready-to-use blenderized diet with chicken and pumpkin in a retort... pouch was developed from regular use formula by nutritionists and dietitians to solve these problems. However, its clinical outcomes should be evaluated. Objectives: To assess the efficacy and safety of a ready-to-use blenderized diet, and to examinePublication Open Access Snacks from Thai herbal plants for patients with gastritis and peptic ulcer(2004-12) Walla Tungrugsasut; Vimol Srisukh; Nuntavan Bunyapraphatsara; Farsai Chanjaruporn; Anan Veenasakulchai; Wilaiwan Thongbainoi; Mahidol University. Faculty of Pharmacy. Department of Food Chemistry; Mahidol University.Faculty of Pharmacy. Department of PharmacognosyTurmeric, banana, and holy basil have shown anti-ulcerogenic activities in several animal studies. Turmeric exhibited the activity in clinical studies as well. Two formulae of snack bars from these Thai herbal plants, to be used as supplements in gastritis and peptic ulcer patients, were developed. Both formulae contained dried ingredients of turmeric (Curcuma longa L.) at 2.5%w/w, holy basil leaves (Ocimum tenuiflorum L.) at 2.5%w/w, and unripe banana (Musa ABB group (triploid) cv. ‘Namwaa’) at 8.75%w/w. Formula 1 (natural flavor) and Formula 2 (cocoa flavor) provided 156.77 and 152.91 Kcal/serving (1 serving = 40 g/5 bars), respectively. Sensory evaluations of the snacks were carried out among 50 panelists, using 9-point Hedonic scale method. There was no significant difference between the two formulae.Publication Open Access Ethnoveterinary medicine based on Ayurveda plants(2012) Sookruetai Boonmasawai; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal ScienceTraditional plants used for medicine exist for several thousand years ago in India to solve human health problems. The Ayurveda concept involved in the balancing of five basic elements including earth, water, fire, air, and space (ether) because of various active ingredients in remedies. Nowadays, traditional plant uses in veterinary medicine in many regions have been documented and reported such as in Spain, Italy, Argentina, Brazil and Kenya. Catharanthus roseus (Apocynaceae) is an important medicinal plant containing vincristine used in veterinary medicine for treatment of canine transmissible venereal tumor and canine lymphoma. Additional evidences in China showed that Salacia oblonga root in Ayurvedic recipe was able to ameliorate hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. Moreover, crude extract from Terminalia arjuna L. (Combretaceae) bark decreased blood pressure in anaesthetized dogs. However, World Health Organization (WHO) recently focuses in standardization, safety and efficacy of Ayurveda medicine to establish this herbal medicine system. Ayurveda in veterinary medicine still need further clinical research to provide more clear, comprehensive, and practical pharmacological information to improve constantly therapeutic qualities.Publication Open Access Ethnoveterinary medicine based on Ayurveda plants(2012) Sookruetai Boonmasawai; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal ScienceTraditional plants used for medicine exist for several thousand years ago in India to solve human health problems. The Ayurveda concept involved in the balancing of five basic elements including earth, water, fire, air, and space (ether) because of various active ingredients in remedies. Nowadays, traditional plant uses in veterinary medicine in many regions have been documented and reported such as in Spain, Italy, Argentina, Brazil and Kenya. Catharanthus roseus (Apocynaceae) is an important medicinal plant containing vincristine used in veterinary medicine for treatment of canine transmissible venereal tumor and canine lymphoma. Additional evidences in China showed that Salacia oblonga root in Ayurvedic recipe was able to ameliorate hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. Moreover, crude extract from Terminalia arjuna L. (Combretaceae) bark decreased blood pressure in anaesthetized dogs. However, World Health Organization (WHO) recently focuses in standardization, safety and efficacy of Ayurveda medicine to establish this herbal medicine system. Ayurveda in veterinary medicine still need further clinical research to provide more clear, comprehensive, and practical pharmacological information to improve constantly therapeutic qualities.Publication Open Access Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation(2012) Sirada Srihirun; Thanaporn Sriwantana; Supeenun Unchern; Dusadee Kittikool; Egarit Noulsri; Kovit Pattanapanyasat; Suthat Fucharoen; Barbora Piknova; Alan N. Schechter; Nathawut Sibmooh; Mahidol University. Institute of Science and Technology for Research and Development. Thalassemia Research Center; Mahidol University. Faculty of Science. Department of PharmacologyBackground Nitrite is a nitric oxide (NO) metabolite in tissues and blood, which can be converted to NO under hypoxia to facilitate tissue perfusion. Although nitrite is known to cause vasodilation following its reduction to NO, the effect of nitrite on platelet activity remains unclear. In this study, the effect of nitrite and nitrite+erythrocytes, with and without deoxygenation, on platelet activity was investigated. Methodology/Finding Platelet aggregation was studied in platelet-rich plasma (PRP) and PRP+erythrocytes by turbidimetric and impedance aggregometry, respectively. In PRP, DEANONOate inhibited platelet aggregation induced by ADP while nitrite had no effect on platelets. In PRP+erythrocytes, the inhibitory effect of DEANONOate on platelets decreased whereas nitrite at physiologic concentration (0.1 µM) inhibited platelet aggregation and ATP release. The effect of nitrite+erythrocytes on platelets was abrogated by C-PTIO (a membrane-impermeable NO scavenger), suggesting an NO-mediated action. Furthermore, deoxygenation enhanced the effect of nitrite as observed from a decrease of P-selectin expression and increase of the cGMP levels in platelets. The ADP-induced platelet aggregation in whole blood showed inverse correlations with the nitrite levels in whole blood and erythrocytes. Conclusion Nitrite alone at physiological levels has no effect on platelets in plasma. Nitrite in the presence of erythrocytes inhibits platelets through its reduction to NO, which is promoted by deoxygenation. Nitrite may have role in modulating platelet activity in the circulation, especially during hypoxia.Publication Open Access Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13 mutations among thai infants(2012) Suporn Treepongkaruna; Suttiruk Jitraruch; Porawee Kodcharin; Dussadee Charoenpipop; Pim Suwannarat; Paneeya Pienvichit; Keiko Kobayashi; Duangrurdee Wattanasirichaigoon1; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of PediatricsBackground: The most common causes of cholestatic jaundice are biliary atresia and idiopathic neonatal hepatitis (INH). Specific disorders underlying INH, such as various infectious and metabolic causes, including neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) especially, in East Asian populations are increasingly being identified. Since most NICCD infants recovered from liver disease by 1 year of age, they often are misdiagnosed with INH, leading to difficulty in determining the true prevalence of NICCD. Mutation(s) of human SLC25A13 gene encoding a mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), can lead to AGC2 deficiency, resulting in NICCD and an adult-onset fatal disease namely citrullinemia type II (CTLN2). To study the prevalence of NICCD and SLC25A13 mutations in Thai infants, and to compare manifestations of NICCD and non-NICCD, infants with idiopathic cholestatic jaundice or INH were enrolled. Clinical and biochemical data were reviewed. Urine organic acid and plasma amino acids profiles were analyzed. PCR-sequencing of all 18 exons of SLC25A13 and gap PCR for the mutations IVS16ins3kb and Ex16+74_IVS17-32del516 were performed. mRNA were analyzed in selected cases with possible splicing error. Results: Five out of 39 (12.8%) unrelated infants enrolled in the study were found to have NICCD, of which three had homozygous 851del4 (GTATdel) and two compound heterozygous 851del4/IVS16ins3kb and 851del4/ 1638ins23, respectively. Two missense mutations (p.M1? and p.R605Q) of unknown functional significance were identified. At the initial presentation, NICCD patients had higher levels of alkaline phosphatase (ALP) and alpha-fetoprotein (AFP) and lower level of alanine aminotransferase (ALT) than those in non-NICCD patients (p< 0.05). NICCD patients showed higher citrulline level and threonine/serine ratio than non-NICCD infants (p< 0.05). Fatty liver was found in 2 NICCD patients. Jaundice resolved in all NICCD and in 87.5% of non-NICCD infants at the median age of 9.5 and 4.0 months, respectively. Conclusion: NICCD should be considered in infants with idiopathic cholestasis. The preliminary estimated prevalence of NICCD was calculated to be 1/48,228 with carrier rate of 1/110 among Thai infants. However, this number may be underestimated and required further analysis with mutation screening in larger control population to establish the true prevalence of NICCD and AGC2 deficiency.