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Publication Metadata only Impact of COMT Val 108/158 Met and DRD2 Taq1B Gene Polymorphisms on Vulnerability to Cigarette Smoking of Thai Males(2013-03-01) Kanjana Suriyaprom; Rungsunn Tungtrongchitr; Talabporn Harnroongroj; Rangsit University; Mahidol UniversityThe nicotine in cigarette smoke can stimulate the dopaminergic reward pathways. The catechol O-methyltransferase gene (COMT) and dopamine receptor 2 gene (DRD2) are dopamine-related genes. Genetic polymorphisms in these two genes are potential... polymorphism, but not associated with DRD2 Taq1B polymorphism. Logistic regression analysis showed that COMT Val108/158Met gene polymorphism, educational status, parental smoking, and alcohol consumption had statistically significant impacts on cigaretteItem Metadata only Analysis of HLA class II gene polymorphisms using monradioactive probes(Mahidol University. Mahidol University Library and Knowledge Center, 2024) Komon Longta; Dasnayanee Chandanayingyong; Stephens, Henry A.F.; Sasitorn BejrachandraPublication Metadata only Estrogen receptor gene polymorphism is associated with bone mineral density in premenopausal women but not in postmenopausal women(1998-01-01) B. Ongphiphadhanakul; R. Rajatanavin; S. Chanprasertyothin; N. Piaseu; L. Chailurkit; R. Sirisriro; S. Komindr; Mahidol University; Faculty of Medicine, Ramathibodi Hospital, Mahidol UniversityIn the present study, we examined the genotypes distribution of Pvu II estrogen receptor (ER) gene polymorphism and its association to bone mass in Thai females. Subjects consisted of 134 Thai females 54 of whom were premenopausal and 80 were... postmenopausal. Pvu II ER gene polymorphism was determined by PCR-RFLP. Capital P represents the absence of the restriction site while small p indicates the presence of the restriction site. Forty nine (36.6%) of the subjects had pp genotype, while 59 (44.0%) hadItem Metadata only The comparative study of gene expression profile in PBMC of SLE during active and inactive stage, the significance of apoptosis, and the detection of polymorphism of candidate genes involved in SLE pathogenesis(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Dhanesh Pitidhammabhorn; Sukathida UbolPublication Metadata only Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus(2006-02-20) Wilaiporn Sakulpipatsin; Oravan Verasertniyom; Kanokrat Nantiruj; Kitti Totemchokchyakarn; Porntawee Lertsrisatit; Suchela Janwityanujit; Mahidol UniversityThe immunomodulatory role of 1,25-dihydroxyvitamin D3 is well known. An association between vitamin D receptor (VDR) gene BsmI polymorphisms and systemic lupus erythematosus (SLE) has been reported. To examine the characteristics of VDR gene Bsm...-restriction fragment length polymorphism (PCR-RFLP). The relationship between VDR gene BsmI polymorphisms and clinical manifestations of SLE was evaluated. The distribution of VDR genotyping in patients with SLE was 1.9% for BB (non-excisable allele homozygotePublication Metadata only The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais(2009-01-01) Kanjana Suriyaprom; Benjaluck Phonrat; Pisit Namjuntra; Siriporn Chanchay; Rungsunn Tungtrongchitr; Rangsit University; Mahidol University; Burapha Universityvolunteers, 105 controls and 95 type 2 diabetes subjects. The purposes of the present study were to investigate the association between two SNPs (single nucleotide polymorphisms) in the resistin gene, at positions +299(G>A) and -420(C>G), and biochemical... parameters; to determine whether these polymorphisms are linked to increased risk of type 2 diabetes. At position +299(G>A) of the resistin gene, the resistin concentration among type 2 diabetes subjects was significantly higher in GA/AA genotypes (3.40 ng/mlPublication Metadata only ID4 gene polymorphism and osteoporosis in Thai menopausal women(2014-01-01) Chaowanee Chupeerach; Sirikul Kulanuwat; Wanida Chuenta; Sivaporn Wannaiampikul; Vanessa Anne Schuh; Sangchai Preutthipan; Rungsunn Tungtrongchitr; Mahidol University; Universitat Potsdamin the ID4 gene polymorphism has not been reported with osteoporosis. Objective: To identify whether ID4 can be a marker gene for osteoporosis in Thai menopausal women. Material and Method: The 3’UTR of ID4 (rs3798339) single nucleotide polymorphism... with the TT genotype, compared with the CT+CC genotypes (p = 0.037). This disappeared after the adjustment of various factors. Conclusion: The polymorphism at 3’UTR of ID4 gene can alter ID4 mRNA stability, and may be linked to the function of proteinsPublication Open Access Predominant genotypes and alleles of two functional polymorphisms in the manganese superoxide dismutase gene are not associated with Thai cervical or breast cancer(2013) Watcharee Attatippaholkun; Kornwipa Wikainapakul; Department of Clinical ChemistryBackground: Defects of manganese superoxide dismutase (MnSOD) have long been implicated in generation of oxidative stress and risk susceptibility to various cancers. Two functional polymorphisms within the MnSOD gene, including the Val-9Ala... and healthy women in Thailand. These two functional polymorphisms (Val-9Ala and Ile58Thr) in MnSOD gene did not associate with susceptibility risk of these cancer patients in Thailand.Publication Metadata only Polymorphism of glutathione S-transferase Omega gene: Association with risk of childhood acute lymphoblastic leukemia(2009-05-01) W. Pongstaporn; S. Pakakasama; S. Sanguansin; S. Hongeng; Songsak Petmitr; Mahidol University; Rangsit UniversityPurpose: To evaluate the association between glutathione S-transferase Omega (GSTO) genes polymorphism and the susceptibility of acute lymphoblast leukemia (ALL). Methods: The polymorphism of GSTO1 and GSTO2 genes were analyzed in 99 ALL patients...142D genotype was significantly interacted with high risk group of childhood ALL (OR = 5.52, 95% CI = 1.72-17.71, P = 0.004). Conclusion: This study revealed gene polymorphism in glutathione S-transferase Omega class may be a risk factorPublication Metadata only The-11377C > G adiponectin gene polymorphism alters the adiponectin concentration and the susceptibility to type 2 diabetes in Thais(2010-12-01) Kanjana Suriyaprom; Benjaluck Phonrat; Pisit Namjuntra; Talabporn Harnroongroj; Rungsunn Tungtrongchitr; Rangsit University; Mahidol Universitymellitus (T2DM) as well as healthy control groups, and to determine whether two adiponectin gene polymorphisms, at the position-11377C > G as well as +45T > G, are associated with serum levels of adiponectin and other variables; then to search... for the association between these two single nucleotide polymorphisms (SNPs) of the adiponectin gene and T2DM. We investigated 93 T2DM patients and 90 healthy volunteers. Compared with the healthy control group, the T2DM group had significantly lower adiponectin