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    The effect of methadone maintenance treatment in improvement of quality of life for heroin users in Hai Phong city, Vietnam
    (Mahidol University. Mahidol University Library and Knowledge Center, 2010) Nguyen, Thi Thanh Ha; Aphichat Chamratrithirong; Charamporn Holumyong
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    Alteration of lymphocyte opioid receptors in methadone maintenance subjects
    (2010-01-01) Tipa Toskulkao; Ruchee Pornchai; Varaporn Akkarapatumwong; Smith Vatanatunyakum; Piyarat Govitrapong; Mahidol University; Thanyarak hospital
    Methadone maintenance therapy is the most widely used treatment in patients with heroin addiction. Multiple studies have suggested that both current and former heroin addicts entering a methadone maintenance treatment program have altered immune... of opiates with lymphocyte opioid receptors. In order to test this hypothesis, the levels of opioid receptors on immune cells obtained from heroin users were determined using saturation binding, and it was found that former heroin addicts on methadone
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    Biphasic Effect of Methadone on Hepatic Drug Metabolism
    (1987-01-01) S. Komthong; K. Yoovathaworn; A. Thithapandha; Mahidol University
    When methadone HC1 (30 mg/kg, po) was given acutely to mice, it was found to inhibit drug metabolism as evidenced by a prolongation of hexobarbital sleeping time and zoxazolamine paralysis time. Pharmacokinetic studies revealed that this acute dose... aminopyrine.N-demethylase or aniline hydroxylase, metadone showed a dose-dependent inhibition of the enzymes; the former enzyme was inhibited to a greater extent than the latter one. However, subacute treatment of mice with methadone HC1 (30 mg/kg, po, twice
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    B vitamins status: Effect of prolonged heroin addiction and methadone treatment
    (1991-01-01) B. Prayurahong; P. Pongpaew; P. Migasena; N. Vudhivai; P. Busapathumrong; Mahidol University
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    Lack of increased HIV risk behavior among injection drug users participating in the AIDSVAX®B/E HIV vaccine trial in Bangkok, Thailand
    (2004-01-23) Frits Van Griensven; Jaranit Keawkungwal; Jordan W. Tappero; Udomsak Sangkum; Punnee Pitisuttithum; Suphak Vanichseni; Pravan Suntharasamai; Karin Orelind; Carolyn Gee; Kachit Choopanya; Thailand Ministry of Public Health; Mahidol University; Bangkok Metropolitan Administration; Bangkok Vaccine Evaluation Group; Centers for Disease Control and Prevention; VaxGen, Inc.
    . At baseline, 61.3% were receiving methadone detoxification and 20.9% were receiving methadone maintenance. From baseline to the 12-month follow-up visit, injection drug use decreased from 93.8% to 66.5% (P < 0.001) and needle sharing from 33.0% to 17.5% (P< 0... (at baseline), younger age, and injection of methamphetamine and midazolam were associated with more-frequent needle sharing; methadone treatment and injecting less than weekly were associated with less-frequent needle sharing. Conclusions: Injection drug use
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    Factors associated with incarceration and incident human immunodeficiency virus (HIV) infection among injection drug users participating in an HIV vaccine trial in Bangkok, Thailand, 1999-2003
    (2009-02-01) Pravan Suntharasamai; Michael Martin; Suphak Vanichseni; Frits Van Griensven; Philip A. Mock; Punnee Pitisuttithum; Jordan W. Tappero; Udomsak Sangkum; Dwip Kitayaporn; Marc Gurwith; Kachit Choopanya; Mahidol University; Thailand Ministry of Public Health; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention; Bangkok Vaccine Evaluation Group; Centers for Disease Control and Prevention; Bangkok Metropolitan Administration; Bumrungrad International Hospital; VaxGen, Inc.; Ministry of Public Healthy
    .0001) and sharing needles (P = 0.02) were associated with HIV infection and methadone maintenance was protective (P = 0.0006). Predictors of incarceration in multivariable analysis included: male sex (P = 0.04), younger age (P < 0.0001), less education (P = 0... prevention tools are needed urgently. HIV prevention services, including methadone, should be made available to IDUs. © 2009 The Authors.
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    Continued high HIV-1 incidence in a vaccine trial preparatory cohort of injection drug users in Bangkok, Thailand
    (2001-02-16) Suphak Vanichseni; Dwip Kitayaporn; Timothy D. Mastro; Philip A. Mock; Suwanee Raktham; Don C.Des Jarlais; Sathit Sujarita; La Ong Srisuwanvilai; Nancy L. Young; Chantapong Wasi; Shambavi Subbarao; William L. Heyward; José Esparza; Kachit Choopanya; Bangkok Metropolitan Administration; HIV/AIDS Collaboration; Mahidol University; Centers for Disease Control and Prevention; Beth Israel Medical Center; UNAIDS; VaxGen, Inc.; Thailand Ministry of Public Health
    of HIV-1 infection and related risk factors to guide prevention efforts and to evaluate the feasibility of conducting an HIV vaccine efficacy trial. Design and methods: A prospective cohort study in which IDUs attending methadone treatment programs... was not associated with increased risk for HIV-1. Risk factors for infection with HIV-1 subtypes E and B were similar. Conclusion: HIV-1 transmission risk remains high among Bangkok IDUs despite methadone treatment and other current prevention strategies
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    Viral hepatitis C infection among people with intravenous drug abuse at Maeramat district, Tak province, Thailand
    (Mahidol University. Mahidol University Library and Knowledge Center, 2024) Shidane, Abdifatah Mohamed, 1990-; Wirongrong Chierakul; Prakaykaew Charunwatthana; Kobporn Boonnak; Saranath Lawpoolsri; Chatporn Kittitrakul
    with the hospital methadone treatment program from 2013 to 2019 were reviewed according to inclusion criteria. RESULTS: 289 people were included in the study. Male participants comprised the overwhelming majority, at 89.6%. Most of the participants were Thai (80... of appropriate preventive measures and additional support for the current methadone treatment program in Mae Ra Mat Hospital. Further studies with HCV RNA confirmation tests are needed.
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    The glucuronidation of R- and S-lorazepam: Human liver microsomal kinetics, UDP-glucuronosyltransferase enzyme selectivity, and inhibition by drugs
    (2013-06-01) Verawan Uchaipichat; Chuthamanee Suthisisang; John O. Miners; Flinders University; Khon Kaen University; Mahidol University
    potential drug-drug interactions, codeine, fluconazole, ketamine, ketoconazole, methadone, morphine, valproic acid, and zidovudine were screened as inhibitors of R- and S-lorazepam glucuronidation by HLM. In vitro-in vivo extrapolation suggested
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    Trends in the injection of midazolam and other drugs and needle sharing among injection drug users enrolled in the AIDSVAX B/E HIV-1 vaccine trial in Bangkok, Thailand
    (2005-06-01) Frits Van Griensven; Punnee Pitisuttithum; Suphak Vanichseni; Paula Wichienkuer; Jordan W. Tappero; Udomsak Sangkum; Dwip Kitayaporn; Boonrawd Phasithiphol; Karin Orelind; Kachit Choopanya; Thailand Ministry of Public Health; Centers for Disease Control and Prevention; Mahidol University; Bangkok Vaccine Evaluation Group; VaxGen, Inc.
    ; younger age, reports of needle sharing and receiving methadone treatment were independently associated with more frequent midazolam injection. Preventive interventions to educate IDUs and midazolam prescribers are urgently needed. © 2005 Elsevier B.V. All