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Item Metadata only Effect of praziquantel on the structure of liver and small intestine in mice(Mahidol University. Mahidol University Library and Knowledge Center, 1991) Kledkaew Panyong; Prasert Sobhon; Suchart Upatham; Chaitip WanichanonThe histological and ultrastructural changes occurring in the liver and small intestine of mice were examined by light and transmission electron microscopy, following the oral administration of praziquantel at the dosages of 250 mg/kg/day for 5... and 10 days and a single dose of 1250 mg/kg/day. Reversible signs of injury were observed in liver cells, following praziquantel administration at the dose 250 mg/kg/day for 10 days. These changes were partial depolymerization of the cytoskeletal networkPublication Metadata only Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration(1983-01-01) Nongporn Hutadilok; Witaya Thamavit; E. Suchart Upatham; Pintip Ruenwongsa; Mahidol University, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg-1body weight, and approached normal levels two weeks after treatment. In the infected hamsters, praziquantel, at a curative dose, caused aPublication Metadata only Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice(2005-09-01) Wannee Jiraungkoorskul; Somphong Sahaphong; Prasert Sobhon; Suda Riengrojpitak; Niwat Kangwanrangsan; Mahidol Universitywith either 300 mg/kg praziquantel or 300 mg/kg artesunate. Mice were sacrificed 1 or 3 days post-treatment. Worms were collected by perfusion and examined by SEM. One to 3 days after administration of artesunate, the tegument of S. mekongi showed severe... swelling, vacuolization, fusion of the tegumental ridges and loss or shortening of the spines on the trabeculae, collapse and peeling. Praziquantel induced similar tegumental alterations as those observed after administration of artesunate, but they werePublication Metadata only Modulation of dihydroxy-di-n-propylnitrosamine-induced liver lesion development in Opisthorchis-infected Syrian hamsters by praziquantel treatment in association with butylated hydroxyanisole or dehydroepiandrosterone administration(1998-01-01) Malcolm A. Moore; Witaya Thamavit; Danai Tiwawech; Nobuyuki Ito; Hiroyuki Tsuda; National Cancer Center Research Institute; Mahidol University; National Cancer Institute Thailand; Nagoya City UniversityThe effects of praziquantel coupled with dehydroepiandrosterone (DHEA) or butylated hydroxyanisole (BHA) administration 16 weeks subsequent to dihydroxy-di-n-propylnitrosamine (DHPN) treatment and infection with Opisthorchis viverrini (OV) on lesion... development in the liver of Syrian hamsters were investigated. Animals were given 80 OV metacercariae and then two i.p. injections of DHPN (500 mg/kg body weight) 4 and 5 weeks thereafter. At week 16, groups received praziquantel (250 mg/kg, i.g.) and werePublication Metadata only Time‐dependent Modulation of Liver Lesion Development in Opisthorchis‐infected Syrian Hamster by an Antihelminthic Drug, Praziquantel(1993-01-01) Witaya Thamavit; Malcolm A. Moore; Stitaya Sirisinha; Tomoyuki Shirai; Nobuyuki Ito; Mahidol University; Nagoya City University Medical Schoolunclear. The effects of administration of praziquantel, an antihelminthic drug, at different time points subsequent to infection with Opisthorchis viverrini (OV) on 2,2′‐dihydroxy‐di‐n‐propylnitrosamine (DHPN)‐initiated lesion development in the liver...). Survivors at week 38 were killed and examined. It was found that whereas praziquantel administration at the earlier two time points was effective at reducing hepatocellular nodule development, the results for cholangiocellular lesions were less pronouncedPublication Metadata only Comparative bioavailability of praziquantel tablets(1989-01-01) S. Kaojarern; S. Nathakarnkikool; U. Suvanakoot; Mahidol Universityfor pharmacokinetic parameters such as maximum serum concentration, time to reach maximum, and area under the curve. Following administration of praziquantel 40 mg/kg po, the mean peak serum concentrations and the time to reach the peak ranged from 1.007 to 1.625 μg...Six different brands of 600 mg praziquantel tablets were evaluated. In vitro studies demonstrated that all but one of the products met the British Pharmacopoeia 1980 disintegration time specifications. The comparative bioavailability of fourPublication Metadata only Plasma concentrations of praziquantel during the therapy of neurocysticerosis with praziquantel, in the presence of antiepileptics and dexamethasone.(1995-03-01) K. Na-Bangchang; S. Vanijanonta; J. Karbwang; Mahidol UniversityPlasma praziquantel concentrations were measured in 11 Thai patients with active neurocysticercosis (8 males and 3 females). Praziquantel (Biltricide 600 mg per tablet) was given at a daily dose of 45 mg/kg given in 3 divided doses for 15... consecutive days. All patients had significant improvement with resolution of symptoms and signs, and reduction of active lesions of cysticercosis shown by the brain computed tomographic scanning. After oral administration, the drug was rapidly absorbed fromPublication Metadata only Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver(1992-01-31) W. Thamavit; M. A. Moore; Somsak Ruchirawat; N. Ito; Mahidol University; Nagoya City University Medical SchoolThe effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11... with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver. © 1992.Publication Metadata only Repeated exposure to opisthorchis viverrini and treatment with the antihelminthic praziquantel lacks carcinogenic potential(1992-02-01) Witaya Thamavit; Malcolm A. Moore; Somsak Ruchirawat; Nobuyuki Ito; Mahidol University; Nagoya City University Medical SchoolThe effects of repeated Praziquantel administration, subsequent to infection and reinfection w Opisthorchis viverrini (OV), on lesion development in the Syrian hamster liver were investigated. Five applications of the antihelminthic drag were made... development of either hepatocellular of cholangiocellular preneoplastic/neoplastic lesions. The results indicate that repeated exposure to Praziquantel at levels sufficient for successful removal of parasite infestation does not itself carry carcinogenic riskPublication Metadata only Experimental investigation of opisthorchiasis-associated cholangiocarcinoma induction in the syrian hamster - pointers for control of the human disease(2003-01-01) Suchart Chaimuangraj; Witaya Thamavit; Hiroyuki Tsuda; Malcolm A. Moore; Mahidol University; National Cancer Center Research Instituteinsult. While removal of the parasite with the antihelminthic drug Praziquantel can protect against carcinogenesis, this is dependent on the timing of the drug administration and the efficacy of application to the human situation remains to be confirmed