Publication: Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
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Issued Date
2011-06-24
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ISSN
15206025
01633864
01633864
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2-s2.0-79959726526
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.74, No.6 (2011), 1386-1391
Suggested Citation
Thitima Lhinhatrakool, Samran Prabpai, Palangpon Kongsaeree, Somyote Sutthivaiyakit Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis. Journal of Natural Products. Vol.74, No.6 (2011), 1386-1391. doi:10.1021/np200014k Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11530
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Title
Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
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Abstract
Eight new sesquiterpene alkaloids (1 - 8) and four known sesquiterpene alkaloids (9 - 12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines. © 2011 The American Chemical Society and American Society of Pharmacognosy.