Publication: Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study
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2011-04-01
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14208008
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2-s2.0-79952332489
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Mahidol University
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Dementia and Geriatric Cognitive Disorders. Vol.31, No.3 (2011), 173-178
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Gobhathai Sittironnarit, David Ames, Ashley I. Bush, Noel Faux, Leon Flicker, Jonathan Foster, Sarah Hilmer, Nicola T. Lautenschlager, Paul Maruff, Colin L. Masters, Ralph N. Martins, Christopher Rowe, Cassandra Szoeke, Kathryn A. Ellis (2011). Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/12584.
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Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study
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Mahidol University
National Ageing Research Institute
Mental Health Research Institute of Victoria
Department of Pathology
University of Melbourne
CogState Ltd.
Austin Health
Commonwealth Scientific and Industrial Research Organization
Western Australian Centre for Health and Ageing
University of Western Australia
Hollywood Private Hospital
Edith Cowan University, Joondalup
The University of Sydney
National Ageing Research Institute
Mental Health Research Institute of Victoria
Department of Pathology
University of Melbourne
CogState Ltd.
Austin Health
Commonwealth Scientific and Industrial Research Organization
Western Australian Centre for Health and Ageing
University of Western Australia
Hollywood Private Hospital
Edith Cowan University, Joondalup
The University of Sydney
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Abstract
Background/Aims: The nature and extent of adverse cognitive effects due to the prescription of anticholinergic drugs in older people with and without dementia is unclear. Methods: We calculated the anticholinergic load (ACL) of medications taken by participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing, a cohort of 211 Alzheimer's disease (AD) patients, 133 mild cognitive impairment (MCI) patients and 768 healthy controls (HC) all aged over 60 years. The association between ACL and cognitive function was examined for each diagnostic group (HC, MCI, AD). Results: A high ACL within the HC group was associated with significantly slower response speeds for the Stroop color and incongruent trials. No other significant relationships between ACL and cognition were noted. Conclusion: In this large cohort, prescribed anticholinergic drugs appeared to have modest effects upon psychomotor speed and executive function, but not on other areas of cognition in healthy older adults. Copyright © 2011 S. Karger AG, Basel.