Publication:
A rare association of α<sup>0</sup>-thalassemia (--<sup>SEA</sup>) and an initiation codon mutation (ATG→A-G) of the α2 gene causes Hb H disease in Thailand

1

Issued Date

2005-08-16

Resource Type

Article

ISSN

03630269

DOI

10.1081/HEM-200066339

Other identifier(s)

2-s2.0-23244456639

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Hemoglobin. Vol.29, No.3 (2005), 235-240

Suggested Citation

Vip Viprakasit, Worrawut Chinchang, Waraporn Glomglao, Voravarn S. Tanphaichitr A rare association of α<sup>0</sup>-thalassemia (--<sup>SEA</sup>) and an initiation codon mutation (ATG→A-G) of the α2 gene causes Hb H disease in Thailand. Hemoglobin. Vol.29, No.3 (2005), 235-240. doi:10.1081/HEM-200066339 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16305

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Title

A rare association of α<sup>0</sup>-thalassemia (--<sup>SEA</sup>) and an initiation codon mutation (ATG→A-G) of the α2 gene causes Hb H disease in Thailand

Author(s)

Vip Viprakasit
 Worrawut Chinchang
 Waraporn Glomglao
 Voravarn S. Tanphaichitr

Other Contributor(s)

Mahidol University

Abstract

Several rare and hitherto unidentified non deletional α-thalassemias (αTα or ααT) have been reported from Thailand within the past few years. Interactions of these determinants with α0-thalassemia (thal) (--/), which is highly prevalent in this region, give rise to various genotypes (--/ αTα or --/ααT) underlying Hb H disease. We report herein the interaction of a rare initiation codon mutation of the α2 gene and α0-thal in a Thal boy with Hb H disease. This finding highlights a wide variety of molecular pathology of the α-globin genes underlying α-thal syndrome in Southeast Asia. Copyright © 2005 Taylor & Francis, Inc.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

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URI

https://repository.li.mahidol.ac.th/handle/123456789/16305

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Scopus 2001-2005