Publication: Structure-activity relationships of dengue antiviral polycyclic quinones
1
Issued Date
2005-07-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-27744551966
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.4 (2005), 901-905
Suggested Citation
Dominique Laurent, Francine Baumann, Anne Gaelle Benoit, Alain Mortelecqe, Narong Nitatpattana, Isabelle Desvignes, Cécile Debitus, Manola Laille, Jean Paul Gonzalez, Eliane Chungue Structure-activity relationships of dengue antiviral polycyclic quinones. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.4 (2005), 901-905. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16939
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Title
Structure-activity relationships of dengue antiviral polycyclic quinones
Abstract
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.